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The Correlation Between Angiotensin II Levels and Homeostatic Model Assessment of Insulin Resistance in Normotensive Young Adults with a Family History of Essential Hypertension

ACTA MEDICA INDONESIANA · Vol. 57 No. 2 (2025)

ISSN
2338-2732, 0125-9326
Terbit
2025-07-08
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: A family history of hypertension increases the risk of renin–angiotensin–aldosterone system activation, insulin resistance, and vascular inflammation, contributing to cardiovascular disease. Early vascular disturbances, marked by angiotensin II and insulin resistance assessed through the homeostatic model assessment of insulin resistance (HOMA-IR), play crucial roles in hypertension development. This study aims to determine the comparison and correlation between Ang II levels and HOMA-IR in normotensive young adults with or without offspring hypertension. Methods: We conducted this cross-sectional study by recruiting fifty normotensive participants, who were categorized into two groups: normotensive young adults who are offspring of parents with essential hypertension (case) and those who are not (control). The serum Ang II and HOMA-IR were measured. The comparative analysis was conducted using the Mann-Whitney test, and correlations were evaluated using Spearman’s test. Results: Among the 50 subjects (25 cases and 25 controls), a significant difference was observed in Ang II levels (p = 0.010), whereas HOMA-IR (p = 0.206) showed no notable difference between case and control. Notably, a positive correlation between Ang II and HOMA-IR (r = 0.554; p = 0.004) was observed in the case group, while the control group exhibited an insignificant correlation (r = –0.089; p = 0.671). Conclusion: There are marked differences in Ang II levels between normotensive young adults with a family history of essential hypertension and those without such history. Additionally, a significant correlation was found between Ang II and HOMA-IR in normotensive young adults who have a family history of essential hypertension.

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  • Hasanuddin University
  • Universitas Muslim Indonesia
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Rekan penulisOrganisasiArtikel bersama
Syakib BakriAfiliasi tidak diketahui2
Muhammad NiswarHasanuddin University1
Muhammad NurHasanuddin University1
Veny HadjuHasanuddin University1
Atjo WahyuHasanuddin University1
Ummu KalsumUniversitas Muslim Indonesia1
Andi Ilham MakhmudAfiliasi tidak diketahui1
Anisa dwirizky AbdullahAfiliasi tidak diketahui1
Berry Erida HasbiAfiliasi tidak diketahui1
Muhammad Asykar PalinrungiHasanuddin University1
Khoirul KholisHasanuddin University1
Syakri SyahrirHasanuddin University1
Firdaus KasimHasanuddin University1
Khalid SalehHasanuddin University1
Burhanuddin BaharHasanuddin University1
Akhtar Fajar MuzakkirHasanuddin University1
Muzakkir AmirHasanuddin University1
Peter KaboHasanuddin University1
Aussie Fitriani GhaznawieHasanuddin University1
Frizt Alfred TandeanHasanuddin University1
Andi Alfian ZainuddinAfiliasi tidak diketahui1
A. Muhammad Akram KastiranAfiliasi tidak diketahui1
Muzakkir AmirAfiliasi tidak diketahui1
Zaenab DjafarAfiliasi tidak diketahui1
Melda WarlianiAfiliasi tidak diketahui1
A Makbul AmanAfiliasi tidak diketahui1
Ilham J PatellongiAfiliasi tidak diketahui1
Hasyim KasimAfiliasi tidak diketahui1
St. Rabiul ZataliaAfiliasi tidak diketahui1
Jerry SampebuntuAfiliasi tidak diketahui1
Octavianus UmbohAfiliasi tidak diketahui1
Emma Syarifih MoiesAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Correlation Between Angiotensin II Levels and Homeostatic Model Assessment of Insulin Resistance in Normotensive Young Adults with a Family History of Essential Hypertension</dc:title>
	<dc:creator>Palar, Stella</dc:creator>
	<dc:creator>Bakri, Syarif</dc:creator>
	<dc:creator>Rasyid, Haerani</dc:creator>
	<dc:creator>Mappangara, Idar</dc:creator>
	<dc:subject xml:lang="en-US">Normotensive</dc:subject>
	<dc:subject xml:lang="en-US">offspring essential hypertension</dc:subject>
	<dc:subject xml:lang="en-US">angiotensin II</dc:subject>
	<dc:subject xml:lang="en-US">HOMA-IR</dc:subject>
	<dc:subject xml:lang="en-US">renal and hypertension</dc:subject>
	<dc:description xml:lang="en-US">Background: A family history of hypertension increases the risk of renin–angiotensin–aldosterone system activation, insulin resistance, and vascular inflammation, contributing to cardiovascular disease. Early vascular disturbances, marked by angiotensin II and insulin resistance assessed through the homeostatic model assessment of insulin resistance (HOMA-IR), play crucial roles in hypertension development. This study aims to determine the comparison and correlation between Ang II levels and HOMA-IR in normotensive young adults with or without offspring hypertension. Methods: We conducted this cross-sectional study by recruiting fifty normotensive participants, who were categorized into two groups: normotensive young adults who are offspring of parents with essential hypertension (case) and those who are not (control). The serum Ang II and HOMA-IR were measured. The comparative analysis was conducted using the Mann-Whitney test, and correlations were evaluated using Spearman’s test. Results: Among the 50 subjects (25 cases and 25 controls), a significant difference was observed in Ang II levels (p = 0.010), whereas HOMA-IR (p = 0.206) showed no notable difference between case and control. Notably, a positive correlation between Ang II and HOMA-IR (r = 0.554; p = 0.004) was observed in the case group, while the control group exhibited an insignificant correlation (r = –0.089; p = 0.671). Conclusion: There are marked differences in Ang II levels between normotensive young adults with a family history of essential hypertension and those without such history. Additionally, a significant correlation was found between Ang II and HOMA-IR in normotensive young adults who have a family history of essential hypertension.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2025-07-08</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">observational analytical cross-sectional study</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2747</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 57 No. 2 (2025): Acta Medica Indonesiana; 222</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2747/795</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Stella Palar, Haerani Rasyid, Syarif Bakri, Idar Mappangara</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>