Melola Discovery

← Melola Discovery

Jurnal SINTA 1

Diagnostic Accuracy of Serum Procalcitonin to Diagnose Sepsis in Advanced Solid Tumor Patients with Fever

ACTA MEDICA INDONESIANA · Vol. 56 No. 2 (2024)

ISSN
2338-2732, 0125-9326
Terbit
2024-07-16
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: Diagnosis of infection in advanced solid tumor patients can be challenging since signs and symptoms might be overlapping due to paraneoplastic condition. Delay diagnosis of existing infection can lead to more severe conditions and increased mortality. Procalcitonin (PCT) has been used to support the diagnosis of bacterial infection and sepsis. Unfortunately, PCT also increases in malignancy even without an infection. We investigated the diagnostic accuracy of PCT in advanced solid tumor patients with fever to diagnose sepsis. Methods: A cross-sectional study was conducted in solid advanced tumor patients with fever patients who were admitted to Cipto Mangunkusumo Hospitals, Indonesia between June 2016 and April 2018. Sepsis was defined using 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference criteria. The diagnostic accuracy of PCT was determined using the receiver operating characteristic (ROC) curve. Results: A total of 194 subjects were enrolled in this study. 60.3% were female with a mean age of 49.47±12.87 years old. 143 patients (73.7%) with advanced solid tumors. Among this latter group, 39 patients (27%) were sepsis. The ROC curve showed that the levels of PCT for sepsis in advanced solid tumor patients with fever were in the area under the curve (AUC) 0.853 (95%CI 0.785 – 0.921). The Cut-off of PCT in advanced solid tumor patients with fever to classify as sepsis was 2.87 ng/mL, with a sensitivity of 79.5%, and a specificity of 79.8%. Conclusion:PCT has good diagnosis accuracy in advanced solid tumor patients with fever to classify as sepsis, however a higher cut-off compared to non-cancerous patients should be used.

Kata kunci

Jaringan kolaborasi para penulis

40 penulis · 253 tautan kepenulisan bersama · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • National Research and Innovation Agency
  • University of Indonesia
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Khie Chen LieAfiliasi tidak diketahui19
Hamzah ShatriAfiliasi tidak diketahui17
Leonard NainggolanAfiliasi tidak diketahui14
Sharifah ShakinahAfiliasi tidak diketahui9
Siti SetiatiAfiliasi tidak diketahui9
Sally Aman NasutionAfiliasi tidak diketahui7
Murdani AbdullahAfiliasi tidak diketahui7
Rudi PutrantoAfiliasi tidak diketahui6
Irsan HasanAfiliasi tidak diketahui6
Alvina WidhaniAfiliasi tidak diketahui6
Adeline PasaribuAfiliasi tidak diketahui5
Mira YuliantiNational Research and Innovation Agency4
Em YunirUniversity of Indonesia4
Ari Fahrial SyamAfiliasi tidak diketahui4
Juferdy KurniawanAfiliasi tidak diketahui4
Noto DwimartutieAfiliasi tidak diketahui4
Herikurniawan HerikurniawanAfiliasi tidak diketahui3
Andhika RachmanAfiliasi tidak diketahui3
Erni J NelwanAfiliasi tidak diketahui3
Ignatius Bima PrasetyaAfiliasi tidak diketahui3
Marcellus SimadibrataAfiliasi tidak diketahui3
Muhadi MuhadiAfiliasi tidak diketahui3
Bradley Jimmy WalelengAfiliasi tidak diketahui3
Evy YunihastutiAfiliasi tidak diketahui3
Adityo SusiloAfiliasi tidak diketahui3
Dadang MakmunAfiliasi tidak diketahui3
Rudy HidayatAfiliasi tidak diketahui3
Pringgodigdo NugrohoAfiliasi tidak diketahui3
Soekamto KoesnoeAfiliasi tidak diketahui3
Lugyanti SukrismanAfiliasi tidak diketahui2
Mulya Rahma KaryantiAfiliasi tidak diketahui2
Andrea LivinaAfiliasi tidak diketahui2
Djoko WidodoAfiliasi tidak diketahui2
Arif MansjoerAfiliasi tidak diketahui2

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Diagnostic Accuracy of Serum Procalcitonin to Diagnose Sepsis in Advanced Solid Tumor Patients with Fever</dc:title>
	<dc:creator>Nelwan, Erni Juwita</dc:creator>
	<dc:creator>Yulisar, Reza Nugraha</dc:creator>
	<dc:creator>Adiwinata, Randy</dc:creator>
	<dc:creator>Rinaldi, Ikhwan</dc:creator>
	<dc:creator>Rumende, Cleopas Martin</dc:creator>
	<dc:creator>Sinto, Robert</dc:creator>
	<dc:subject xml:lang="en-US">Procalcitonin</dc:subject>
	<dc:subject xml:lang="en-US">Solid tumor</dc:subject>
	<dc:subject xml:lang="en-US">Advance Stage Cancer</dc:subject>
	<dc:subject xml:lang="en-US">Sepsis</dc:subject>
	<dc:subject xml:lang="en-US">Cut-off</dc:subject>
	<dc:description xml:lang="en-US">Background: Diagnosis of infection in advanced solid tumor patients can be challenging since signs and symptoms might be overlapping due to paraneoplastic condition. Delay diagnosis of existing infection can lead to more severe conditions and increased mortality. Procalcitonin (PCT) has been used to support the diagnosis of bacterial infection and sepsis. Unfortunately, PCT also increases in malignancy even without an infection. We investigated the diagnostic accuracy of PCT in advanced solid tumor patients with fever to diagnose sepsis. Methods: A cross-sectional study was conducted in solid advanced tumor patients with fever patients who were admitted to Cipto Mangunkusumo Hospitals, Indonesia between June 2016 and April 2018. Sepsis was defined using 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference criteria. The diagnostic accuracy of PCT was determined using the receiver operating characteristic (ROC) curve. Results: A total of 194 subjects were enrolled in this study. 60.3% were female with a mean age of 49.47±12.87 years old. 143 patients (73.7%) with advanced solid tumors. Among this latter group, 39 patients (27%) were sepsis. The ROC curve showed that the levels of PCT for sepsis in advanced solid tumor patients with fever were in the area under the curve (AUC) 0.853 (95%CI 0.785 – 0.921). The Cut-off of PCT in advanced solid tumor patients with fever to classify as sepsis was 2.87 ng/mL, with a sensitivity of 79.5%, and a specificity of 79.8%. Conclusion:PCT has good diagnosis accuracy in advanced solid tumor patients with fever to classify as sepsis, however a higher cut-off compared to non-cancerous patients should be used. </dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2024-07-16</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2773</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 56 No. 2 (2024): Acta Medica Indonesiana; 199</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2773/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 Erni Juwita Nelwan, Reza Nugraha Yulisar, Randy Adiwinata, Ikhwan Rinaldi, Cleopas Martin Rumende, Robert Sinto</dc:rights>
</oai_dc:dc>