Melola Discovery

← Melola Discovery

Jurnal SINTA 1

The Role of Inflammatory Parameters and Antibody Seroconversion on COVID-19 Outcomes in Patients with Central Obesity

ACTA MEDICA INDONESIANA · Vol. 56 No. 4 (2025)

ISSN
2338-2732, 0125-9326
Terbit
2025-01-21
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng

Abstrak

Background: Central obesity increases the risk of developing poor outcomes of COVID-19. The pro-inflammatory state and antibody dysfunction are thought to contribute to poor outcomes; however, the evidence is unclear. Methods: This is a cohort study among COVID-19 patients with central obesity in Dr. Cipto Mangunkusumo National General Hospital Jakarta, Indonesia, during the early phase of the COVID-19 pandemic. Our study is a part of the COVID-19, Aging, and Cardiometabolic Risk Factors (CARAMEL) study. From the CARAMEL study, we selected adult non-ICU/HCU inpatient subjects with central obesity that met inclusion/exclusion criteria, collected clinical and anthropometric data, and measured inflammatory cytokines and IgG S-RBD SARS-CoV-2 antibody titers from a stored sample taken at day 2 of hospitalization. The poor clinical outcome of hospitalization was observed. We used the Mann-Whitney test to analyse non-normally distributed data, and T-test for normally-distributed data. The adjusted-relative risk of negative seroconversion antibody for poor outcomes was analysed using logistic regression. Results: 23 of 178 (12.9%) subjects developed poor clinical outcomes during hospitalization. Subjects with poor outcomes had a higher visceral fat area (14.5 vs. 11, p < 0.05), waist circumference and BMI. The level of CRP, pro-inflammatory cytokines (IL-6 and MCP-1) and anti-inflammatory cytokines (IL-1Ra, IL-4, and IL-10) were significantly higher in subjects with poor outcomes, alongside with the lower antibody titer in subjects with poor outcomes. Antibody seroconversion failure increased the risk of developing poor outcomes (aRR 2.696, 95% CI 1.024-7.101), after adjusting for age and sex. Conclusion: In COVID-19 patients with central obesity, we confirmed the association between higher pro- and anti-inflammatory parameters, and lower SARS-CoV-2 antibody with poor outcomes of COVID-19.

Kata kunci

Jaringan kolaborasi para penulis

40 penulis · 302 tautan kepenulisan bersama · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Sekolah Tinggi Ilmu Kesehatan Husada Jombang
  • University of Indonesia
  • National Research and Innovation Agency
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Siti SetiatiAfiliasi tidak diketahui17
Imam SubektiAfiliasi tidak diketahui12
Hamzah ShatriAfiliasi tidak diketahui10
Sally Aman NasutionAfiliasi tidak diketahui10
Rudi PutrantoAfiliasi tidak diketahui8
Dyah PurnamasariAfiliasi tidak diketahui8
Wismandari WisnuAfiliasi tidak diketahui8
Juferdy KurniawanAfiliasi tidak diketahui8
Mira YuliantiNational Research and Innovation Agency7
Em YunirUniversity of Indonesia7
Iris RengganisAfiliasi tidak diketahui7
Idrus AlwiAfiliasi tidak diketahui6
Ikhwan RinaldiAfiliasi tidak diketahui6
Sukamto KoesnoeAfiliasi tidak diketahui6
Alvina WidhaniAfiliasi tidak diketahui6
Eka Dian SafitriAfiliasi tidak diketahui6
Rahmi IstantiAfiliasi tidak diketahui6
Eka GinanjarAfiliasi tidak diketahui6
Noto DwimartutieAfiliasi tidak diketahui5
Anshari Saifuddin HasibuanAfiliasi tidak diketahui5
Suzy MariaAfiliasi tidak diketahui5
Andhika RachmanAfiliasi tidak diketahui5
Ceva Wicaksono PitoyoAfiliasi tidak diketahui5
Pringgodigdo NugrohoAfiliasi tidak diketahui5
Roza MulyanaAfiliasi tidak diketahui4
Aida LydiaAfiliasi tidak diketahui4
Robert SintoAfiliasi tidak diketahui4
Leonard NainggolanAfiliasi tidak diketahui4
Birry KarimAfiliasi tidak diketahui3

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Role of Inflammatory Parameters and Antibody Seroconversion on COVID-19 Outcomes in Patients  with Central Obesity</dc:title>
	<dc:creator>Wafa, Syahidatul</dc:creator>
	<dc:creator>Tahapary, Dicky Levenus</dc:creator>
	<dc:creator>Yunihastuti, Evy</dc:creator>
	<dc:creator>Wibowo, Heri</dc:creator>
	<dc:creator>Rumende, Cleopas Martin</dc:creator>
	<dc:creator>Harimurti, Kuntjoro</dc:creator>
	<dc:creator>Suastika, Ketut</dc:creator>
	<dc:creator>Kurniawan, Farid</dc:creator>
	<dc:creator>Kartika, Rona</dc:creator>
	<dc:creator>Pradnjaparamita, Tika</dc:creator>
	<dc:creator>Harbuwono, Dante Saksono</dc:creator>
	<dc:subject xml:lang="en-US">inflammatory parameters</dc:subject>
	<dc:subject xml:lang="en-US">antibody response</dc:subject>
	<dc:subject xml:lang="en-US">COVID-19 severity</dc:subject>
	<dc:subject xml:lang="en-US">central obesity</dc:subject>
	<dc:subject xml:lang="en-US">poor outcome</dc:subject>
	<dc:description xml:lang="en-US">Background: Central obesity increases the risk of developing poor outcomes of COVID-19. The pro-inflammatory state and antibody dysfunction are thought to contribute to poor outcomes; however, the evidence is unclear. Methods: This is a cohort study among COVID-19 patients with central obesity in Dr. Cipto Mangunkusumo National General Hospital Jakarta, Indonesia, during the early phase of the COVID-19 pandemic. Our study is a part of the COVID-19, Aging, and Cardiometabolic Risk Factors (CARAMEL) study. From the CARAMEL study, we selected adult non-ICU/HCU inpatient subjects with central obesity that met inclusion/exclusion criteria, collected clinical and anthropometric data, and measured inflammatory cytokines and IgG S-RBD SARS-CoV-2 antibody titers from a stored sample taken at day 2 of hospitalization. The poor clinical outcome of hospitalization was observed. We used the Mann-Whitney test to analyse non-normally distributed data, and T-test for normally-distributed data. The adjusted-relative risk of negative seroconversion antibody for poor outcomes was analysed using logistic regression. Results: 23 of 178 (12.9%) subjects developed poor clinical outcomes during hospitalization. Subjects with poor outcomes had a higher visceral fat area (14.5 vs. 11, p &amp;lt; 0.05), waist circumference and BMI. The level of CRP, pro-inflammatory cytokines (IL-6 and MCP-1) and anti-inflammatory cytokines (IL-1Ra, IL-4, and IL-10) were significantly higher in subjects with poor outcomes, alongside with the lower antibody titer in subjects with poor outcomes. Antibody seroconversion failure increased the risk of developing poor outcomes (aRR 2.696, 95% CI 1.024-7.101), after adjusting for age and sex. Conclusion: In COVID-19 patients with central obesity, we confirmed the association between higher pro- and anti-inflammatory parameters, and lower SARS-CoV-2 antibody with poor outcomes of COVID-19.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2025-01-21</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2791</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 56 No. 4 (2024): Acta Medica Indonesiana; 483</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2791/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Syahidatul Wafa, Dicky Tahapary, Evy Yunihastuti, Heri Wibowo, Cleopas Martin Rumende, Kuntjoro Harimurti, Ketut Suastika, Farid Kurniawan, Rona Kartika, Tika Pradnjaparamita, Dante Saksono Harbuwono</dc:rights>
</oai_dc:dc>