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The Impact of Palliative Care on Quality of Life and Cortisol Levels in HIV/AIDS Patients with Anxiety

ACTA MEDICA INDONESIANA · Vol. 57 No. 2 (2025)

ISSN
2338-2732, 0125-9326
Terbit
2025-07-08
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: Individuals with HIV/AIDS often experience significant physical and mental burdens. Palliative care has emerged as a means to improve the quality of life for people living with HIV/AIDS (PLWHA). This study aims to determine the effect of palliative care on the quality of life and psychoneuroimmunoendocrine aspects in PLWHA, particularly those suffering from anxiety, as indicated by cortisol hormone levels. Methods: A total of 30 PLWHA with anxiety were selected based on inclusion and exclusion criteria. This study employed a quantitative design with a quasi-experimental one-group pre-test and post-test approach. The data were analyzed using descriptive statistics and a paired t-test to assess the impact of the intervention on quality of life and cortisol hormone levels. Results: The findings indicated a significant improvement in quality of life following palliative care (p = 0.000, p 0.05). Conclusion: Palliative care significantly enhances the quality of life in PLWHA. However, it does not lead to a statistically significant reduction in cortisol hormone levels before and after the intervention. Factors such as patient compliance with the palliative care plan and the influence of efavirenz on cortisol levels in PLWHA are likely contributing to these results.

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Shuhei UedaAfiliasi tidak diketahui6
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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The  Impact of Palliative Care on Quality of Life and Cortisol Levels in HIV/AIDS Patients with Anxiety</dc:title>
	<dc:creator>Maskoep, Wiwiek Indriyani</dc:creator>
	<dc:creator>Khairunisa, Siti Qamariyah</dc:creator>
	<dc:creator>Rachman, Brian Eka</dc:creator>
	<dc:creator>Ciuputri, Pauline</dc:creator>
	<dc:creator>Admadiani, Fhahira Rizkhika</dc:creator>
	<dc:creator>Andini, Sarah Fitria</dc:creator>
	<dc:creator>Asmarawati, Tri Pudi</dc:creator>
	<dc:creator>Nasronudin, Nasronudin</dc:creator>
	<dc:subject xml:lang="en-US">palliative care</dc:subject>
	<dc:subject xml:lang="en-US">people living with HIV/AIDS</dc:subject>
	<dc:subject xml:lang="en-US">PLWHA</dc:subject>
	<dc:subject xml:lang="en-US">cortisol hormone</dc:subject>
	<dc:subject xml:lang="en-US">quality of life</dc:subject>
	<dc:subject xml:lang="en-US">HIV</dc:subject>
	<dc:description xml:lang="en-US">Background: Individuals with HIV/AIDS often experience significant physical and mental burdens. Palliative care has emerged as a means to improve the quality of life for people living with HIV/AIDS (PLWHA). This study aims to determine the effect of palliative care on the quality of life and psychoneuroimmunoendocrine aspects in PLWHA, particularly those suffering from anxiety, as indicated by cortisol hormone levels. Methods: A total of 30 PLWHA with anxiety were selected based on inclusion and exclusion criteria. This study employed a quantitative design with a quasi-experimental one-group pre-test and post-test approach. The data were analyzed using descriptive statistics and a paired t-test to assess the impact of the intervention on quality of life and cortisol hormone levels. Results: The findings indicated a significant improvement in quality of life following palliative care (p = 0.000, p &amp;lt; 0.05). The cortisol levels in PLWHA with anxiety decreased following palliative care; however, the reduction was not statistically significant, suggesting that palliative care had no measurable impact on cortisol levels post-intervention (p = 0.845, p &amp;gt; 0.05). Conclusion: Palliative care significantly enhances the quality of life in PLWHA. However, it does not lead to a statistically significant reduction in cortisol hormone levels before and after the intervention. Factors such as patient compliance with the palliative care plan and the influence of efavirenz on cortisol levels in PLWHA are likely contributing to these results.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2025-07-08</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2792</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 57 No. 2 (2025): Acta Medica Indonesiana; 212</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2792/794</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Wiwiek Indriyani Maskoep, Siti Qamariyah Khairunisa, Brian Eka Rachman, Pauline Ciuputri, Fhahira Rizkhika Admadiani, Sarah Fitria Andini, Tri Pudi Asmarawati, nasronudin Nasronudin</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>