Melola Discovery

← Melola Discovery

Akses terbuka Jurnal SINTA 1

Effect of Ramadan Fasting on Malondialdehyde, Poly (ADP-Ribose) Polymerase, Sirtuin 1, Nuclear Receptor Subfamily 1 Group D Member 1, and Transforming Growth Factor Beta in Chronic Kidney Disease: A Prospective Cohort Study

ACTA MEDICA INDONESIANA · Vol. 57 No. 2 (2025)

ISSN
2338-2732, 0125-9326
Terbit
2025-07-08
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: Chronic kidney disease (CKD) is a global health problem with increasing prevalence. This study aims to analyze the effect of Ramadan fasting on important biomarkers in CKD patients. Methods: A prospective cohort study was conducted on 30 CKD patients with stages 1, 2, and 3A who underwent Ramadan fasting. Measurements of MDA, PARP, SIRT1, NR1D1, and TGF-β levels were carried out before fasting, 2 weeks during fasting, and after fasting using the Enzyme-linked immunosorbent assay (ELISA) method. Results: There were significant decreases in urea, fasting blood glucose, HbA1C, and uric acid levels (p<0.05). MDA and SIRT1 decreased significantly (p<0.001), while PARP and NR1D1 increased significantly (p<0.001). TGF-β also showed a decrease. There were no significant changes in lipid profiles, creatinine, and albumin. Conclusion: Ramadan fasting has significant effects on several biochemical parameters and biological markers in early-stage CKD patients. These changes indicate potential improvements in oxidative stress, cell autophagy, inflammation regulation, and circadian rhythm. Further studies are needed to evaluate the long-term effects and clinical implications of these findings in CKD management.

Kata kunci

Jaringan kolaborasi para penulis

11 penulis · 20 tautan kepenulisan bersama · 4 lintas organisasi

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Andalas University
  • National Research and Innovation Agency
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Arni AmirAndalas University2
Miskah Indah Syahid MP MiskahindahsyahidmpAfiliasi tidak diketahui1
Endah Puji SeptisetyaniNational Research and Innovation Agency1
Ria Fajarwati KastianNational Research and Innovation Agency1
Dita FauziahAndalas University1
HasmiwatiAfiliasi tidak diketahui1
Yuhendri PutraAndalas University1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Effect of Ramadan Fasting on Malondialdehyde, Poly (ADP-Ribose) Polymerase, Sirtuin 1, Nuclear Receptor Subfamily 1 Group D Member 1, and Transforming Growth Factor Beta in Chronic Kidney Disease: A Prospective Cohort Study</dc:title>
	<dc:creator>Priyono, Drajad</dc:creator>
	<dc:creator>Yerizel, Eti</dc:creator>
	<dc:creator>Harun, Harnavi</dc:creator>
	<dc:creator>Suharti, Netti</dc:creator>
	<dc:subject xml:lang="en-US">biomarkers</dc:subject>
	<dc:subject xml:lang="en-US">Chronic Kidney Disease</dc:subject>
	<dc:subject xml:lang="en-US">Inflammation</dc:subject>
	<dc:subject xml:lang="en-US">Ramadan fasting</dc:subject>
	<dc:subject xml:lang="en-US">Oxidative stress</dc:subject>
	<dc:subject xml:lang="en-US">Internal Medicine</dc:subject>
	<dc:subject xml:lang="en-US">neph</dc:subject>
	<dc:subject xml:lang="en-US">biomedicine</dc:subject>
	<dc:description xml:lang="en-US">Background: Chronic kidney disease (CKD) is a global health problem with increasing prevalence. This study aims to analyze the effect of Ramadan fasting on important biomarkers in CKD patients. Methods: A prospective cohort study was conducted on 30 CKD patients with stages 1, 2, and 3A who underwent Ramadan fasting. Measurements of MDA, PARP, SIRT1, NR1D1, and TGF-β levels were carried out before fasting, 2 weeks during fasting, and after fasting using the Enzyme-linked immunosorbent assay (ELISA) method. Results: There were significant decreases in urea, fasting blood glucose, HbA1C, and uric acid levels (p&amp;lt;0.05). MDA and SIRT1 decreased significantly (p&amp;lt;0.001), while PARP and NR1D1 increased significantly (p&amp;lt;0.001). TGF-β also showed a decrease. There were no significant changes in lipid profiles, creatinine, and albumin. Conclusion: Ramadan fasting has significant effects on several biochemical parameters and biological markers in early-stage CKD patients. These changes indicate potential improvements in oxidative stress, cell autophagy, inflammation regulation, and circadian rhythm. Further studies are needed to evaluate the long-term effects and clinical implications of these findings in CKD management.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2025-07-08</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2911</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 57 No. 2 (2025): Acta Medica Indonesiana; 228</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2911/796</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Drajad Priyono, Eti Yerizel, Harnavi Harun, Netti Suharti</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>