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Correlation of Serum FT4 with Serum Uric Acid and Comparison of Uric Acid in Subjects with and without Atrial Fibrillation in Graves’ Disease: A Cross-Sectional Study

ACTA MEDICA INDONESIANA · Vol. 57 No. 3 (2025)

ISSN
2338-2732, 0125-9326
Terbit
2025-10-03
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: Cardiovascular diseases increase the mortality risk in Graves’ disease (GD) patients. Atrial fibrillation (AF) is one of the most prevalent cardiovascular diseases in GD. Hyperthyroidism that occurs in GD may increase uric acid levels, while uric acid levels can also increase the risk of AF in the general population. This study is designed to observe the correlation between free T4 (FT4) and uric acid, and compare the levels of uric acid in subjects with and without AF in GD. Methods: A cross-sectional study was conducted, including GD patients who met research criteria in Dr. Cipto Mangunkusumo Hospital during 2024. We performed history taking, physical examination, laboratory examination, and electrocardiogram for each subject. Data was analyzed using Pearson or Spearman correlation, and bivariate analysis to evaluate the comparison of uric acid in subjects with and without AF. Results: We included 74 subjects, with an average age of 41 years, mostly female (86.5%), and 62.2% had normal FT4 levels. AF occurred only in 4.1% subjects. Mean of uric acid is 4.71 ± 1.2 mg/dl, which is within the normal range. No correlation was found between FT4 and uric acid (r = 0.076; p = 0.520), including after adjustment with subgroup analysis based on thyroid status, gender, and diabetes mellitus. Mean of uric acid is not statistically different between subjects with and without AF (4.9 ± 1.01 mg/dl vs 4.7 ± 1.2 mg/dl; p = 0.785). Conclusion: No significant correlation was found between FT4 and uric acid. Mean of uric acid is not statistically different between subjects with and without AF.

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Hamzah ShatriAfiliasi tidak diketahui20
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Ikhwan RinaldiAfiliasi tidak diketahui11
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Em YunirUniversity of Indonesia7
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Dicky Levenus TahaparyAfiliasi tidak diketahui7
Rino Alvani GaniAfiliasi tidak diketahui6
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Mira YuliantiNational Research and Innovation Agency5
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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Correlation of Serum FT4 with Serum Uric Acid and Comparison of Uric Acid in Subjects with and without Atrial Fibrillation in Graves’ Disease: A Cross-Sectional Study</dc:title>
	<dc:creator>Yunita, Bella</dc:creator>
	<dc:creator>Subekti, Imam</dc:creator>
	<dc:creator>Karim, Birry</dc:creator>
	<dc:creator>Abdullah, Murdani</dc:creator>
	<dc:creator>Rumende, Cleopas Martin</dc:creator>
	<dc:creator>Purnamasari, Dyah </dc:creator>
	<dc:creator>Kurniawan, Juferdy</dc:creator>
	<dc:creator>Susilo, Adityo</dc:creator>
	<dc:subject xml:lang="en-US">Atrial fibrillation</dc:subject>
	<dc:subject xml:lang="en-US">Free T4</dc:subject>
	<dc:subject xml:lang="en-US">Graves’ disease</dc:subject>
	<dc:subject xml:lang="en-US">Uric acid</dc:subject>
	<dc:description xml:lang="en-US">Background: Cardiovascular diseases increase the mortality risk in Graves’ disease (GD) patients. Atrial fibrillation (AF) is one of the most prevalent cardiovascular diseases in GD. Hyperthyroidism that occurs in GD may increase uric acid levels, while uric acid levels can also increase the risk of AF in the general population. This study is designed to observe the correlation between free T4 (FT4) and uric acid, and compare the levels of uric acid in subjects with and without AF in GD. Methods: A cross-sectional study was conducted, including GD patients who met research criteria in Dr. Cipto Mangunkusumo Hospital during 2024. We performed history taking, physical examination, laboratory examination, and electrocardiogram for each subject. Data was analyzed using Pearson or Spearman correlation, and bivariate analysis to evaluate the comparison of uric acid in subjects with and without AF. Results: We included 74 subjects, with an average age of 41 years, mostly female (86.5%), and 62.2% had normal FT4 levels. AF occurred only in 4.1% subjects. Mean of uric acid is 4.71 ± 1.2 mg/dl, which is within the normal range. No correlation was found between FT4 and uric acid (r = 0.076; p = 0.520), including after adjustment with subgroup analysis based on thyroid status, gender, and diabetes mellitus. Mean of uric acid is not statistically different between subjects with and without AF (4.9 ± 1.01 mg/dl vs 4.7 ± 1.2 mg/dl; p = 0.785). Conclusion: No significant correlation was found between FT4 and uric acid. Mean of uric acid is not statistically different between subjects with and without AF. </dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2025-10-03</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/2919</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 57 No. 3 (2025): Acta Medica Indonesiana; 346</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/2919/813</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Bella Yunita, Imam Subekti, Birry Karim, Murdani Abdullah, Cleopas Martin Rumende, Rr Dyah Purnamasari Sulistianingsih, Juferdy Kurniawan, Adityo Susilo</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>