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The Role of Probiotics in Depression and Quality of Life in Patients with Irritable Bowel Syndrome

ACTA MEDICA INDONESIANA · Vol. 57 No. 4 (2025)

ISSN
2338-2732, 0125-9326
Terbit
2025-12-23
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder frequently accompanied by psychological disturbances such as depression and reduced quality of life. Probiotic intervention has been studied as a potential adjunct therapy to address psychological symptoms and improve the quality of life in IBS patients. This study aims to evaluate the effect of probiotic supplementation on depressive symptoms and quality of life in IBS patients at Dr. Cipto Mangunkusumo National General Hospital using the Beck Depression Inventory-II (BDI-II) and SF-36 instruments. Methods: This study was a double-blind randomized controlled trial with a pre-post intervention design. A total of 70 participants were randomly assigned into two groups: the intervention group (n=35), which received probiotics, and the control group (n=35), which received a placebo. Depressive symptoms were assessed using the BDI-II, while quality of life was measured using the SF-36 questionnaire, both before and after the intervention. Statistical analysis was performed using the Mann-Whitney test and independent t-test, with a significance level of p<0.05. Results: After the intervention, the probiotic group showed a significant reduction in BDI-II scores compared to the placebo group (p<0.0001). In addition, the probiotic group demonstrated significant improvements in almost all domains of the SF-36 compared to the placebo group, including physical functioning, role physical, bodily pain, general health, vitality, social functioning, emotional well-being, and mental health (p<0.0001). Conclusion: Probiotic supplementation significantly reduces depressive symptoms and improves quality of life in IBS patients. These findings support the potential of probiotics as an adjunct therapy in the comprehensive management of IBS.

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  • Institut Agama Islam Negeri Bone
  • University of Indonesia
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Rekan penulisOrganisasiArtikel bersama
Ikhwan RinaldiAfiliasi tidak diketahui21
Edward FaisalAfiliasi tidak diketahui20
Cleopas Martin RumendeAfiliasi tidak diketahui16
Siti SetiatiAfiliasi tidak diketahui15
Kuntjoro HarimurtiAfiliasi tidak diketahui12
Juferdy KurniawanAfiliasi tidak diketahui11
Dadang MakmunAfiliasi tidak diketahui11
Alvina WidhaniAfiliasi tidak diketahui10
Sally Aman NasutionAfiliasi tidak diketahui10
Iris RengganisAfiliasi tidak diketahui9
Marcellus SimadibrataAfiliasi tidak diketahui8
Em YunirUniversity of Indonesia8
Pringgodigdo NugrohoAfiliasi tidak diketahui8
Idrus AlwiAfiliasi tidak diketahui8
Cosphiadi IrawanAfiliasi tidak diketahui8
Rudy HidayatAfiliasi tidak diketahui8
Imam SubektiAfiliasi tidak diketahui7
Chyntia Olivia Maurine JasirwanAfiliasi tidak diketahui7
Hasan MaulahelaAfiliasi tidak diketahui7
Ari Fahrial SyamAfiliasi tidak diketahui7
Kaka RenaldiAfiliasi tidak diketahui7
Rino Alvani GaniAfiliasi tidak diketahui6
Dyah PurnamasariAfiliasi tidak diketahui6
Simon SalimAfiliasi tidak diketahui5
Muhammad YaminInstitut Agama Islam Negeri Bone5
Andri Sanityoso SulaimanAfiliasi tidak diketahui5
Arif MansjoerAfiliasi tidak diketahui5
Leonard NainggolanAfiliasi tidak diketahui5
Evy YunihastutiAfiliasi tidak diketahui5
Dono AntonoAfiliasi tidak diketahui4
Ni Made HustriniAfiliasi tidak diketahui4
Andri SanityosoAfiliasi tidak diketahui3

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The  Role of Probiotics in Depression and Quality of Life in Patients with Irritable Bowel Syndrome</dc:title>
	<dc:creator>Erlita, Diana </dc:creator>
	<dc:creator>Shatri, Hamzah</dc:creator>
	<dc:creator>Fauzi, Achmad</dc:creator>
	<dc:creator>Abdullah, Murdani </dc:creator>
	<dc:creator>Putranto, Rudi </dc:creator>
	<dc:creator>Ginanjar, Eka </dc:creator>
	<dc:creator>Hasan, Irsan</dc:creator>
	<dc:creator>Rachman, Andhika</dc:creator>
	<dc:subject xml:lang="en-US">Probiotics</dc:subject>
	<dc:subject xml:lang="en-US">irritable bowel syndrome</dc:subject>
	<dc:subject xml:lang="en-US">Depression</dc:subject>
	<dc:subject xml:lang="en-US">quality of life</dc:subject>
	<dc:subject xml:lang="en-US">BDI-II</dc:subject>
	<dc:subject xml:lang="en-US">SF-36</dc:subject>
	<dc:description xml:lang="en-US">Background: Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder frequently accompanied by psychological disturbances such as depression and reduced quality of life. Probiotic intervention has been studied as a potential adjunct therapy to address psychological symptoms and improve the quality of life in IBS patients. This study aims to evaluate the effect of probiotic supplementation on depressive symptoms and quality of life in IBS patients at Dr. Cipto Mangunkusumo National General Hospital using the Beck Depression Inventory-II (BDI-II) and SF-36 instruments. Methods: This study was a double-blind randomized controlled trial with a pre-post intervention design. A total of 70 participants were randomly assigned into two groups: the intervention group (n=35), which received probiotics, and the control group (n=35), which received a placebo. Depressive symptoms were assessed using the BDI-II, while quality of life was measured using the SF-36 questionnaire, both before and after the intervention. Statistical analysis was performed using the Mann-Whitney test and independent t-test, with a significance level of p&amp;lt;0.05. Results: After the intervention, the probiotic group showed a significant reduction in BDI-II scores compared to the placebo group (p&amp;lt;0.0001). In addition, the probiotic group demonstrated significant improvements in almost all domains of the SF-36 compared to the placebo group, including physical functioning, role physical, bodily pain, general health, vitality, social functioning, emotional well-being, and mental health (p&amp;lt;0.0001). Conclusion: Probiotic supplementation significantly reduces depressive symptoms and improves quality of life in IBS patients. These findings support the potential of probiotics as an adjunct therapy in the comprehensive management of IBS.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2025-12-23</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/3069</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 57 No. 4 (2025): Acta Medica Indonesiana; 485</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/3069/831</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Diana  Erlita, Hamzah Shatri, Achmad Fauzi, Murdani Abdullah, Rudi Putranto, Eka Ginanjar, Irsan Hasan, Andhika Rachman</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>