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The Emergence of Drug Resistance in Extrapulmonary Tuberculosis: A Case Series

ACTA MEDICA INDONESIANA · Vol. 57 No. 4 (2025)

ISSN
2338-2732, 0125-9326
Terbit
2025-12-23
Penerbit
The Indonesian Society of Internal Medicine
Bahasa
eng
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Drug-resistant extrapulmonary tuberculosis (DR-EPTB) represents an escalating global health challenge, complicated by rising rates of rifampicin-resistant (RR-TB) and multidrug-resistant tuberculosis (MDR-TB). Despite growing awareness, DR-EPTB remains underdiagnosed and underreported, often due to presumptive assumptions of drug sensitivity. This case series describes three distinct cases of DR-EPTB: a 34-year-old woman diagnosed with primary MDR-TB involving the lungs and colon; a 41-year-old man with RR-TB-associated arthritis of the elbow joint, following a previous history of pulmonary TB; and a 63-year-old immunosuppressed woman presenting with primary laryngeal and pulmonary RR-TB. These cases highlight the diagnostic complexities and emphasize the necessity of prompt and precise diagnosis facilitated by molecular diagnostics, particularly GeneXpert MTB/RIF. Increased awareness and vigilance for DR-EPTB among clinicians are critical for early detection, effective management, and curbing the spread of drug-resistant strains.

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  • University of Indonesia
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Hamzah ShatriAfiliasi tidak diketahui7
Siti SetiatiAfiliasi tidak diketahui7
Eric Daniel TendaAfiliasi tidak diketahui7
Ikhwan RinaldiAfiliasi tidak diketahui5
Gurmeet SinghAfiliasi tidak diketahui5
Ceva Wicaksono PitoyoAfiliasi tidak diketahui4
I Putu Eka Krisnha WijayaAfiliasi tidak diketahui4
Christian JohanAfiliasi tidak diketahui4
Kuntjoro HarimurtiAfiliasi tidak diketahui4
Sally Aman NasutionAfiliasi tidak diketahui3
Murdani AbdullahAfiliasi tidak diketahui3
Khie Chen LieAfiliasi tidak diketahui3
Erni Juwita NelwanAfiliasi tidak diketahui3
Em YunirUniversity of Indonesia3
Rudi PutrantoAfiliasi tidak diketahui3
Robert SintoAfiliasi tidak diketahui3
Evy YunihastutiAfiliasi tidak diketahui3
Ari Fahrial SyamAfiliasi tidak diketahui3
Adityo SusiloAfiliasi tidak diketahui3
Ignatius Bima PrasetyaAfiliasi tidak diketahui2
Erwin C SusantoAfiliasi tidak diketahui2
Truely P SitorusAfiliasi tidak diketahui2
Leonard NainggolanAfiliasi tidak diketahui2
Soekamto KoesnoeAfiliasi tidak diketahui2
Iris RengganisAfiliasi tidak diketahui2
Petrin Redayani LukmanAfiliasi tidak diketahui2
Hasan MaulahelaAfiliasi tidak diketahui2
Imam SubektiAfiliasi tidak diketahui2
Juferdy KurniawanAfiliasi tidak diketahui2
Irsan HasanAfiliasi tidak diketahui1
Wismandari WisnuAfiliasi tidak diketahui1
Edward J HadiAfiliasi tidak diketahui1
Gloria TanjungAfiliasi tidak diketahui1
Imelda N SaputriAfiliasi tidak diketahui1
Raditya SasongkoAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://www.actamedindones.org/index.php/ijim/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">The Emergence of Drug Resistance in Extrapulmonary Tuberculosis: A Case Series</dc:title>
	<dc:creator>Herikurniawan, Herikurniawan</dc:creator>
	<dc:creator>Harris, Aziza</dc:creator>
	<dc:creator>Yulianti, Mira</dc:creator>
	<dc:creator>Kusuma, Ni Nyoman Indirawati</dc:creator>
	<dc:creator>Rumende, Cleopas Martin</dc:creator>
	<dc:subject xml:lang="en-US">Tuberculosis</dc:subject>
	<dc:subject xml:lang="en-US">multi-drug resistant</dc:subject>
	<dc:subject xml:lang="en-US">extrapulmonary</dc:subject>
	<dc:subject xml:lang="en-US">rifampicin</dc:subject>
	<dc:subject xml:lang="en-US">molecular diagnostic technique</dc:subject>
	<dc:subject xml:lang="en-US">drug resistance</dc:subject>
	<dc:subject xml:lang="en-US">Bacterial</dc:subject>
	<dc:description xml:lang="en-US">Drug-resistant extrapulmonary tuberculosis (DR-EPTB) represents an escalating global health challenge, complicated by rising rates of rifampicin-resistant (RR-TB) and multidrug-resistant tuberculosis (MDR-TB). Despite growing awareness, DR-EPTB remains underdiagnosed and underreported, often due to presumptive assumptions of drug sensitivity. This case series describes three distinct cases of DR-EPTB: a 34-year-old woman diagnosed with primary MDR-TB involving the lungs and colon; a 41-year-old man with RR-TB-associated arthritis of the elbow joint, following a previous history of pulmonary TB; and a 63-year-old immunosuppressed woman presenting with primary laryngeal and pulmonary RR-TB. These cases highlight the diagnostic complexities and emphasize the necessity of prompt and precise diagnosis facilitated by molecular diagnostics, particularly GeneXpert MTB/RIF. Increased awareness and vigilance for DR-EPTB among clinicians are critical for early detection, effective management, and curbing the spread of drug-resistant strains.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Society of Internal Medicine</dc:publisher>
	<dc:date>2025-12-23</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://www.actamedindones.org/index.php/ijim/article/view/3097</dc:identifier>
	<dc:source xml:lang="en-US">Acta Medica Indonesiana; Vol. 57 No. 4 (2025): Acta Medica Indonesiana; 521</dc:source>
	<dc:source>2338-2732</dc:source>
	<dc:source>0125-9326</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://www.actamedindones.org/index.php/ijim/article/view/3097/836</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Herikurniawan Herikurniawan</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>