Akses terbuka Jurnal SINTA 1
Anticholinergic Burden, Falls, and the Concept of Appropriate Polypharmacy in Indonesian Geriatric Clinics: A Multicentre Observational Study
ACTA MEDICA INDONESIANA · Vol. 58 No. 2 (2026)
- ISSN
- 2338-2732, 0125-9326
- Terbit
- 2026-07-03
- Penerbit
- The Indonesian Society of Internal Medicine
- Bahasa
- eng
Abstrak
Background: A high anticholinergic burden (ACB) scale score (≥3) and polypharmacy have been viewed negatively due to possible adverse events. As Indonesian multicentre data in this field are lacking, this study aimed to provide regional data related to ACB, polypharmacy, and falls, and to analyse factors potentially linked to falls. Methods: Data from community-dwelling older adults aged ≥60 years were collected in 12 geriatric care centres through history taking and medical records. Bivariate and multivariate analyses were conducted to evaluate the association between covariates and falls. Results: Polypharmacy and high ACB (score ≥3) were observed in 43.9% and 1.8% of 626 older adults, respectively. The five most prescribed drug classes were calcium-channel blockers, angiotensin receptor blockers, statins, beta blockers, and proton pump inhibitors. The three most prescribed drugs with possible anticholinergic activity were furosemide, isosorbide dinitrate, and cetirizine. The prevalence of past-year falls was 16.8%. Falls were associated with age ≥80 years (odds ratio [OR] 2.44, 95% confidence interval [CI] 1.31-4.53), female sex (OR 2.08, 95% CI 1.30-3.31), transient ischaemic attack and cerebrovascular accident (OR 1.97, 95% CI 0.94-4.10), multimorbidity (≥3 co-morbidities) (OR 1.80, 95% CI 1.07-3.03), depression (OR 1.79, 95% CI 1.00-3.23), and polypharmacy (OR 0.65, 95% CI 0.40-1.05). Conclusion: The prevalence of a high ACB score and falls were 1.8% and 16.8%, respectively. Approximately one in two older adults had polypharmacy. We observed a non-significant inverse relationship between polypharmacy and falls. This may possibly suggest appropriate polypharmacy and closer monitoring applied in geriatric settings, which requires further investigation.
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| Rekan penulis | Organisasi | Artikel bersama |
|---|---|---|
| Jessica Marsigit | Afiliasi tidak diketahui | 18 |
| Aulia Rizka | Afiliasi tidak diketahui | 13 |
| Hamzah Shatri | Afiliasi tidak diketahui | 11 |
| Eka Dian Safitri | Afiliasi tidak diketahui | 11 |
| Siti Rizny F Saldi | Afiliasi tidak diketahui | 10 |
| Ikhwan Rinaldi | Afiliasi tidak diketahui | 9 |
| Idrus Alwi | Afiliasi tidak diketahui | 8 |
| Rudi Putranto | Afiliasi tidak diketahui | 8 |
| Cleopas Martin Rumende | Afiliasi tidak diketahui | 7 |
| Evy Yunihastuti | Afiliasi tidak diketahui | 6 |
| Rudy Hidayat | Afiliasi tidak diketahui | 6 |
| Dyah Purnamasari | Afiliasi tidak diketahui | 6 |
| Eka Ginanjar | Afiliasi tidak diketahui | 6 |
| Imam Subekti | Afiliasi tidak diketahui | 6 |
| Suhendro Suwarto | Afiliasi tidak diketahui | 5 |
| Purwita W Laksmi | Afiliasi tidak diketahui | 5 |
| Muhammad Yamin | Afiliasi tidak diketahui | 5 |
| Aida Lydia | Afiliasi tidak diketahui | 5 |
| Eric Daniel Tenda | Afiliasi tidak diketahui | 5 |
| Iris Rengganis | Afiliasi tidak diketahui | 4 |
| Juferdy Kurniawan | Afiliasi tidak diketahui | 4 |
| Andhika Rachman | Afiliasi tidak diketahui | 3 |
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