Akses terbuka Jurnal SINTA 1
Production of Insect Toxin Beauvericin from Entomopathogenic Fungi Cordyceps militaris by Heterologous Expression of Global Regulator
AGRIVITA, Journal of Agricultural Science · Vol. 40 No. 1 (2017) · hlm. 177–184
- ISSN
- 2477-8516, 0126-0537
- Terbit
- 2017-12-20
- Penerbit
- Faculty of Agriculture University of Brawijaya in collaboration with PERAGI
- Bahasa
- eng
Abstrak
Cordyceps militaris is one of entomopathogenic fungi species that is well known to be a traditional medicine in China for decades. Although the pharmaceutical and/or toxic properties of C. militaris has attracted attention as a promising resource for finding bioactive compounds, only a few substances including cordycepin have been reported so far. In the previous report heterologous expression of LaeA, a global regulator for secondary metabolites production in fungi, has been succeeded in C. militaris. The LaeA-engineered transformants are proved to produce new and/or elevated production of secondary metabolites, as detected by HPLC analysis. In order to further characterize the secondary metabolites that were being significantly produced by LaeA transformant, HPLC profiling and structure elucidation by proton NMR were conducted in two target compounds, designated as compound 1 and compound 2. Compound 1 possessed the highly similar characters to insect toxin beauvericin in UV spectrum, molecular weight, and retention time in HPLC analysis. Proton NMR analysis revealed that compound 1 had the same proton signals as beauvericin.
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- University of Brawijaya
- State University of Semarang
- International Center for Biotechnology, The University of Osaka
- Yogyakarta State University
- Afiliasi tidak diketahui
- Organisasi berbeda
- Organisasi sama
- Afiliasi tidak diketahui
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Tampilkan sebagai tabel
| Rekan penulis | Organisasi | Artikel bersama |
|---|---|---|
| Muhammad Akhid Syib’li | University of Brawijaya | 2 |
| Aminudin Afandhi | University of Brawijaya | 2 |
| Kurnia Rizkya Sang Saka Maharani | State University of Semarang | 1 |
| Alvin Fadholi | Afiliasi tidak diketahui | 1 |
| Retno Sri Iswari | State University of Semarang | 1 |
| Siti Fathonah | Afiliasi tidak diketahui | 1 |
| Rosidah Rosidah | Yogyakarta State University | 1 |
| Bela Siska Kristanti | Afiliasi tidak diketahui | 1 |
| Diva Maharani Putri | State University of Semarang | 1 |
| Sita Nurmasitah | Afiliasi tidak diketahui | 1 |
| Anugrah Sabila Pratiwi | Afiliasi tidak diketahui | 1 |
| Sania Dwi Andini | Afiliasi tidak diketahui | 1 |
| Diana Pangestututi | Afiliasi tidak diketahui | 1 |
| Nabila Husnannisa | Afiliasi tidak diketahui | 1 |
| Nanik Yulianis | Afiliasi tidak diketahui | 1 |
| Fajar Setyowati | Afiliasi tidak diketahui | 1 |
| Bambang Tri Rahardjo | University of Brawijaya | 1 |
| David Soetjipto | University of Brawijaya | 1 |
| Ito Fernando | University of Brawijaya | 1 |
| Yogo Setiawan | University of Brawijaya | 1 |
| Retno Dyah Puspitarini | University of Brawijaya | 1 |
| Bayu Aji Pamungkas | University of Brawijaya | 1 |
| Anisya Putri Karina | University of Brawijaya | 1 |
| Huurul Ainindya Ulihta Zain | University of Brawijaya | 1 |
| Theresia Rani Kartika Ayu | Afiliasi tidak diketahui | 1 |
| Akhmad Rizali | University of Brawijaya | 1 |
| Abdul Latief Abadi | University of Brawijaya | 1 |
| Hagus Tarno | University of Brawijaya | 1 |
| Luqman Qurata Aini | University of Brawijaya | 1 |
| Muhammad Irfan Febriansyah | University of Brawijaya | 1 |
| Cahyo Prayogo | University of Brawijaya | 1 |
| Noegraha Sholehuddin | University of Brawijaya | 1 |
| Eka Zainul Hasan Syahfinada Putra | University of Brawijaya | 1 |
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