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Biopharmaceutical potential of indonesian husk tomato (Physalis angulata L.): genetic diversity, metabolite biosynthesis, and breeding for enhanced fruit quality

AGRIVITA, Journal of Agricultural Science · Vol. 48 No. 3 (2026) · hlm. 711–724

DOI
10.17503/agrivita.v48i3.5055
ISSN
2477-8516, 0126-0537
Terbit
2026-09-09
Penerbit
Faculty of Agriculture University of Brawijaya in collaboration with PERAGI
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc/4.0

Abstrak

The Husk Tomato (Physalis angulata L.) has been valued as a medicinal plant due to its rich secondary metabolites. These compounds include physalins, which exhibit antitumor activity; withanolides, recognized as potent anti-inflammatory agents; and other components such as flavonoids, phenolic acids, alkaloids, and carotenoids. Despite its therapeutic potential, the commercial utilization of P. angulata remains limited by inconsistent fruit quality. This review summarizes current knowledge on Indonesian P. angulata germplasm, focusing on its botany, growth characteristics, genetic diversity, and metabolite profiles. Previous reviews mainly discussed botanical and pharmacological properties, whereas this review emphasizes Indonesian germplasm diversity and breeding perspectives. We critically evaluate several breeding strategies aimed at improving fruit quality, including the utilization of genetic resources, hybridization, mutation breeding, polyploidization, and in vitro techniques. Furthermore, we highlight the application of genetic engineering, particularly the overexpression of the squalene synthase (SQS) gene, suggesting that this approach could efficiently enhance the biosynthesis of squalene derivatives, such as physalins and withanolides. By evaluating the achievements and challenges of these strategies in P. angulata and other Solanaceae species, this review offers a roadmap for future research, aiming to maximize fruit quality and unlock the extensive biopharmaceutical applications of the Indonesian Husk Tomato.

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  • Universitas Muhammadiyah Bengkulu
  • Lampung University
  • Walailak University
  • National Research and Innovation Agency
  • Jenderal Soedirman University
  • Institut Agama Islam Negeri Kendari
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Rekan penulisOrganisasiArtikel bersama
Agus PurwitoAfiliasi tidak diketahui8
Hanudin HanudinAfiliasi tidak diketahui6
Budi MarwotoAfiliasi tidak diketahui5
Wakiah NuryaniAfiliasi tidak diketahui4
Kuswanto KuswantoAfiliasi tidak diketahui4
Indijarto Budi RahardjoAfiliasi tidak diketahui4
Muji SetiyoAfiliasi tidak diketahui4
Evi Silvia YusufAfiliasi tidak diketahui3
Sasanti WidiarsihAfiliasi tidak diketahui3
Elok Rifqi FirdianaNational Research and Innovation Agency3
Ahmad Syahrian SiregarAfiliasi tidak diketahui3
Izmi YulianahAfiliasi tidak diketahui3
Tya Resta FitrianaAfiliasi tidak diketahui2
Prima VeronikaAfiliasi tidak diketahui2
Darmawan SaptadiAfiliasi tidak diketahui2
Puji LestariJenderal Soedirman University2
Bagiyo Condro PurnomoAfiliasi tidak diketahui2
Muhammad Latifur RochmanAfiliasi tidak diketahui2
Arifin Noor SugihartoAfiliasi tidak diketahui2
Devi MienantiAfiliasi tidak diketahui2
Iqbal HidayatAfiliasi tidak diketahui2
Yanuar DanaatmadjaAfiliasi tidak diketahui2
Mohammad Bahrelfi BelaffifAfiliasi tidak diketahui2
Ajay Goel KumarAfiliasi tidak diketahui2
Nurul AiniInstitut Agama Islam Negeri Kendari2
Wiwin Sumiya Dwi YamikaAfiliasi tidak diketahui2
Aditya KolakotiAfiliasi tidak diketahui2
Dwinita Wikan UtamiAfiliasi tidak diketahui2
Irwandi IrwandiUniversitas Muhammadiyah Bengkulu1
Mariana Ade CahayaUniversitas Muhammadiyah Bengkulu1

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Sumber metadata: OAI-PMH (metadata jurnal) https://agrivita.ub.ac.id/index.php/agrivita/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Biopharmaceutical potential of indonesian husk tomato (Physalis angulata L.): genetic diversity, metabolite biosynthesis, and breeding for enhanced fruit quality</dc:title>
	<dc:creator>Shoidah, Fajriyatus</dc:creator>
	<dc:creator>Fadillah, Muhammad Asya</dc:creator>
	<dc:creator>Martasari, Chaireni</dc:creator>
	<dc:creator>Nugroho, Kristianto</dc:creator>
	<dc:creator>Wulandari, Dyah Retno</dc:creator>
	<dc:creator>Kosmiatin, Mia</dc:creator>
	<dc:creator>Husni, Ali</dc:creator>
	<dc:creator>Waluyo, Budi</dc:creator>
	<dc:creator>Budiarto, Kurniawan</dc:creator>
	<dc:creator>Yusuf, Hadi Mokhamad</dc:creator>
	<dc:subject xml:lang="en-US">horticulture; plant breeding; metabolic engineering</dc:subject>
	<dc:subject xml:lang="en-US">biochemical compounds; genetic modification; medicinal species; metabolite biosynthesis; solanaceae crops</dc:subject>
	<dc:description xml:lang="en-US">The Husk Tomato (Physalis angulata L.) has been valued as a medicinal plant due to its rich secondary metabolites. These compounds include physalins, which exhibit antitumor activity; withanolides, recognized as potent anti-inflammatory agents; and other components such as flavonoids, phenolic acids, alkaloids, and carotenoids. Despite its therapeutic potential, the commercial utilization of P. angulata remains limited by inconsistent fruit quality. This review summarizes current knowledge on Indonesian P. angulata germplasm, focusing on its botany, growth characteristics, genetic diversity, and metabolite profiles. Previous reviews mainly discussed botanical and pharmacological properties, whereas this review emphasizes Indonesian germplasm diversity and breeding perspectives. We critically evaluate several breeding strategies aimed at improving fruit quality, including the utilization of genetic resources, hybridization, mutation breeding, polyploidization, and in vitro techniques. Furthermore, we highlight the application of genetic engineering, particularly the overexpression of the squalene synthase (SQS) gene, suggesting that this approach could efficiently enhance the biosynthesis of squalene derivatives, such as physalins and withanolides. By evaluating the achievements and challenges of these strategies in P. angulata and other Solanaceae species, this review offers a roadmap for future research, aiming to maximize fruit quality and unlock the extensive biopharmaceutical applications of the Indonesian Husk Tomato.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Agriculture University of Brawijaya in collaboration with PERAGI</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2026-09-09</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://agrivita.ub.ac.id/index.php/agrivita/article/view/5055</dc:identifier>
	<dc:identifier>10.17503/agrivita.v48i3.5055</dc:identifier>
	<dc:source xml:lang="en-US">AGRIVITA Journal of Agricultural Science; Vol 48, No 3 (2026): October 2026; 711-724</dc:source>
	<dc:source>2477-8516</dc:source>
	<dc:source>0126-0537</dc:source>
	<dc:source>10.17503/agrivita.v48i3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://agrivita.ub.ac.id/index.php/agrivita/article/view/5055/2056</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2026 Fajriyatus Shoidah, Muhammad Asya Fadillah, Chaireni Martasari, Kristianto Nugroho, Dyah Retno Wulandari, Mia Kosmiatin, Ali Husni, Budi Waluyo, Kurniawan Budiarto, Hadi Mokhamad Yusuf</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc/4.0</dc:rights>
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