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Synthesis and Characterization of Poly(Amidoamine) Dendrimers Encapsulated 198Au Nanoparticles

Atom Indonesia · Vol. 38 No. 3 (2013) · hlm. 118–126

DOI
10.17146/aij.2012.176
ISSN
2356-5322, 0126-1568
Terbit
2013-02-13
Penerbit
National Research and Innovation Agency
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

Brachytherapy or internal radiotherapy is one of many methods used for treatment of cancer. This modality requires an agent with radionuclides that emits α or β particle with a proper energy. 198Au (99% β max = 0.96 MeV and t1/2 = 2.69 days) is one of radionuclides that has been considered to be effective for the above-mentioned purpose. The purpose of this research was to synthesis and characterize poly(amidoamine) (PAMAM) G3.0 dendrimers encapsulated 198Au nanoparticles as a new brachytherapy agent. PAMAM G3.0 dendrimers encapsulated 198Au nanoparticles was successfully synthesized by a bottom-up method using sodium borohydride as a reductor. Purification was then performed by a size exclusion chromatography in order to separate large Au nanoparticles that were formed outside the cavity of PAMAM G3.0 dendrimers. Prior to the synthesis of PAMAM G3.0 dendrimers encapsulated 198Au nanoparticles, the synthetic procedure was first established by using a non-radioactive Au. The PAMAM G3.0 dendrimers encapsulated Au nanoparticles produced was then characterized by using an UV-Vis spectroscopy, a transmission electron microscopy (TEM), particle size analyzer (PSA), and an atomic absorption spectroscopy (AAS). Characterization results revealed that PAMAM G3.0 dendrimers encapsulated Au nanoparticles that were prepared from a reaction mixture of PAMAM G3.0 dendrimers and Au HAuCl4 with mol ratio of 2.8, was found to be a proper formula. It produced PAMAM G3.0 dendrimers encapsulated Au nanoparticles with diameter of 1.743 nm, spheris, uniform and drug loading value of 26.34%. This formula was then used in synthesis using radioactive Au, 198Au. Characterization results of PAMAM G3.0 dendrimers encapsulated 198Au nanoparticles gave a radiochemical purity of 99.4% and zero charge. Received: 04 December 2012; Revised: 18 December 2012; Accepted: 20 December 2012

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Rekan penulisOrganisasiArtikel bersama
V.Y. SusiloAfiliasi tidak diketahui4
S. SetiyowatiAfiliasi tidak diketahui3
R.D. HaryuniAfiliasi tidak diketahui3
C.N. ArdiyatnoAfiliasi tidak diketahui3
Nur'aeni Nur'aeniAfiliasi tidak diketahui2
Adi Indradi WazdiAfiliasi tidak diketahui2
Triningsih TriningsihAfiliasi tidak diketahui2
W. LestariAfiliasi tidak diketahui2
P. WidayatiAfiliasi tidak diketahui2
A. AriyantoAfiliasi tidak diketahui2
L.B.S. KardonoAfiliasi tidak diketahui2
M MarlinaAfiliasi tidak diketahui2
E. SarminiAfiliasi tidak diketahui2
I. SaptiamaAfiliasi tidak diketahui2
H. LubisAfiliasi tidak diketahui2
I. KambaliAfiliasi tidak diketahui2
M MaiyesniAfiliasi tidak diketahui2
S. FebrianaAfiliasi tidak diketahui2
Nur HidayahPoliteknik Negeri Ujung Pandang2
Husni HanafiAfiliasi tidak diketahui2
Dewi Elizadiani SuzaAfiliasi tidak diketahui2
Nursalam NursalamAfiliasi tidak diketahui2
Diah PriyantiniAfiliasi tidak diketahui2
Elsi Dwi HapsariAfiliasi tidak diketahui2
Naurah AbidahAfiliasi tidak diketahui1
Balqis RizkiaAfiliasi tidak diketahui1
Nasywa Azalia WijayaAfiliasi tidak diketahui1
Muhammad Raikmal MaksumAfiliasi tidak diketahui1
Muhammad JuanAfiliasi tidak diketahui1
Praja Razaqul‘ Ilmi GintingAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://atomindonesia.brin.go.id/index.php/aij/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Synthesis and Characterization of Poly(Amidoamine) Dendrimers Encapsulated  198Au Nanoparticles</dc:title>
	<dc:creator>Ritawidya, R.</dc:creator>
	<dc:creator>Pujiyanto, A.</dc:creator>
	<dc:creator>Mujinah, Mujinah</dc:creator>
	<dc:creator>Witarti, Witarti</dc:creator>
	<dc:creator>Setiawan, Setiawan</dc:creator>
	<dc:creator>Ramli, M.</dc:creator>
	<dc:creator>Kurniasih, D.</dc:creator>
	<dc:creator>Yanuar, A.</dc:creator>
	<dc:creator>Mutalib, A.</dc:creator>
	<dc:creator>Kardono, L.B.</dc:creator>
	<dc:subject xml:lang="en-US">198Au nanoparticles, PAMAM G3.0 dendrimers, Size exclusion chromatography, Transmission electron microscopy (TEM)</dc:subject>
	<dc:description xml:lang="en-US">Brachytherapy or internal radiotherapy is one of many methods used for treatment of cancer. This modality requires an agent with radionuclides that emits α or β particle with a proper energy. 198Au (99% β max = 0.96 MeV and t1/2 = 2.69 days) is one of radionuclides that has been considered to be effective for the above-mentioned purpose. The purpose of this research was to synthesis and characterize poly(amidoamine) (PAMAM) G3.0 dendrimers encapsulated 198Au nanoparticles as a new brachytherapy agent. PAMAM G3.0 dendrimers encapsulated 198Au nanoparticles was successfully synthesized by a bottom-up method using sodium borohydride as a reductor. Purification was then performed by a size exclusion chromatography in order to separate large Au nanoparticles that were formed outside the cavity of PAMAM G3.0 dendrimers. Prior to the synthesis of PAMAM G3.0 dendrimers encapsulated 198Au nanoparticles, the synthetic procedure was first established by using a non-radioactive Au. The PAMAM G3.0 dendrimers encapsulated Au nanoparticles produced was then characterized by using an UV-Vis spectroscopy, a transmission electron microscopy (TEM), particle size analyzer (PSA), and an atomic absorption spectroscopy (AAS). Characterization results revealed that PAMAM G3.0 dendrimers encapsulated Au nanoparticles that were prepared from a reaction mixture of PAMAM G3.0 dendrimers and Au HAuCl4 with mol ratio of 2.8, was found to be a proper formula. It produced PAMAM G3.0 dendrimers encapsulated Au nanoparticles with diameter of 1.743 nm, spheris, uniform and drug loading value of 26.34%. This formula was then used in synthesis using radioactive Au, 198Au. Characterization results of PAMAM G3.0 dendrimers encapsulated 198Au nanoparticles gave a radiochemical purity of 99.4% and zero charge. Received: 04 December 2012; Revised: 18 December 2012; Accepted: 20 December 2012</dc:description>
	<dc:publisher xml:lang="en-US">National Research and Innovation Agency</dc:publisher>
	<dc:contributor xml:lang="en-US">National Nuclear Energy Agency of Indonesia</dc:contributor>
	<dc:date>2013-02-13</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://atomindonesia.brin.go.id/index.php/aij/article/view/176</dc:identifier>
	<dc:identifier>10.17146/aij.2012.176</dc:identifier>
	<dc:source xml:lang="en-US">Atom Indonesia; Vol 38, No 3 (2012): December 2012; 118-126</dc:source>
	<dc:source>2356-5322</dc:source>
	<dc:source>0126-1568</dc:source>
	<dc:source>10.17146/aij.2012.%x</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://atomindonesia.brin.go.id/index.php/aij/article/view/176/128</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2016 Atom Indonesia</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>