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Jurnal
SINTA 1
Radiolabeling Technique of Silver Nanoparticles (AgNPs) with Iodine-131 Radionuclide
Atom Indonesia
ISSN 2356-5322, 0126-1568
Terbit 2020-08-05
Penerbit National Research and Innovation Agency
Bahasa eng
Abstrak
Radiotherapy is an effective cancer therapy, where a certain dose of radiation is aimed specifically at target and is unaffecting to normal tissue. A selectiveradionuclide must be attached to the specific targeted organ. In this research, silver nanoparticles (AgNPs) were labeled with radionuclide of iodine-131 (131I) to be used in radiotherapy. Silver nanoparticles were synthesized using silver nitrate 0.0005 M, sodium borohydride 0.002 M, polyvinylpyrrolidone 0.3 % (w/v) and natrium chloride 1.5 M, and then followed by purification by centrifugation. Characterization was carried out with UV-Vis spectrophotometer, transmission electron microscope, particle size analyzer, and zeta-sizer. The results show that the maximum absorbance is on a wavelength of 398 nm, spherical shape with a diameter of 10 nm, polydispersity index of 0.455, and zeta potential value of –8 mV. The radiolabeling was done by adding sodium iodide-131 which had been oxidized by chloramine-T and immobilized in AgNPs colloidal solution, and the activity was then measured using a dose calibrator. The identification of radionuclide showed that the sample was free of impurities. The optimum system of radiochemical purity was obtained using Whatman 1 paper strip as the stationary phase and a mixture of methanol: water: ammonium acetate (1:1:1) as the mobile phase, which gave 96 % purity. This method is suitable for radiolabeling AgNPs with 131I to be used for radiotherapy.
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Sumber metadata: OAI-PMH (metadata jurnal) https://atomindonesia.brin.go.id/index.php/aij/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc)
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<dc:title xml:lang="en-US">Radiolabeling Technique of Silver Nanoparticles (AgNPs) with Iodine-131 Radionuclide</dc:title>
<dc:creator>Sholikhah, U.N.</dc:creator>
<dc:creator>Syahdi, R.R.</dc:creator>
<dc:creator>Permatasari, S.E.</dc:creator>
<dc:creator>Sarmini, E.</dc:creator>
<dc:creator>Sriyono, S</dc:creator>
<dc:creator>Widyaningrum, T.</dc:creator>
<dc:subject xml:lang="en-US">Gamma counter; Radiochemical purity; Radionuclide purity; Radiotheraphy</dc:subject>
<dc:description xml:lang="en-US"> Radiotherapy is an effective cancer therapy, where a certain dose of radiation is aimed specifically at target and is unaffecting to normal tissue. A selectiveradionuclide must be attached to the specific targeted organ. In this research, silver nanoparticles (AgNPs) were labeled with radionuclide of iodine-131 (131I) to be used in radiotherapy. Silver nanoparticles were synthesized using silver nitrate 0.0005 M, sodium borohydride 0.002 M, polyvinylpyrrolidone 0.3 % (w/v) and natrium chloride 1.5 M, and then followed by purification by centrifugation. Characterization was carried out with UV-Vis spectrophotometer, transmission electron microscope, particle size analyzer, and zeta-sizer. The results show that the maximum absorbance is on a wavelength of 398 nm, spherical shape with a diameter of 10 nm, polydispersity index of 0.455, and zeta potential value of –8 mV. The radiolabeling was done by adding sodium iodide-131 which had been oxidized by chloramine-T and immobilized in AgNPs colloidal solution, and the activity was then measured using a dose calibrator. The identification of radionuclide showed that the sample was free of impurities. The optimum system of radiochemical purity was obtained using Whatman 1 paper strip as the stationary phase and a mixture of methanol: water: ammonium acetate (1:1:1) as the mobile phase, which gave 96 % purity. This method is suitable for radiolabeling AgNPs with 131I to be used for radiotherapy.</dc:description>
<dc:publisher xml:lang="en-US">National Research and Innovation Agency</dc:publisher>
<dc:contributor xml:lang="en-US">National Nuclear Enegry Agency</dc:contributor>
<dc:date>2020-08-05</dc:date>
<dc:type>info:eu-repo/semantics/article</dc:type>
<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
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<dc:format>application/pdf</dc:format>
<dc:identifier>https://atomindonesia.brin.go.id/index.php/aij/article/view/745</dc:identifier>
<dc:identifier>10.17146/aij.2020.745</dc:identifier>
<dc:source xml:lang="en-US">Atom Indonesia; Vol 46, No 2 (2020): August 2020; 63-68</dc:source>
<dc:source>2356-5322</dc:source>
<dc:source>0126-1568</dc:source>
<dc:source>10.55981/aij.v46i2</dc:source>
<dc:language>eng</dc:language>
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<dc:rights xml:lang="en-US">Copyright (c) 2020 Atom Indonesia</dc:rights>
<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
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APA 7
Sholikhah, U., Syahdi, R., Permatasari, S., Sarmini, E., Sriyono, S., & Widyaningrum, T. (2020). Radiolabeling Technique of Silver Nanoparticles (AgNPs) with Iodine-131 Radionuclide. Atom Indonesia, 46(2), 63–68. https://doi.org/10.17146/aij.2020.745
Salin
IEEE
U. Sholikhah, R. Syahdi, S. Permatasari, E. Sarmini, S. Sriyono, and T. Widyaningrum, “Radiolabeling Technique of Silver Nanoparticles (AgNPs) with Iodine-131 Radionuclide,” Atom Indonesia, vol. 46, no. 2, pp. 63–68, 2020, doi: 10.17146/aij.2020.745.
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