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HEPATOPROTECTIVE EFFECT OF Physalis angulata L. LEAF ETHANOL EXTRACT AGAINST BUSULFAN-INDUCED LIVER DAMAGE IN FEMALE RATS

BIOTROPIA · Vol. 33 No. 3 (2026) · hlm. 378–388

DOI
10.11598/btb.2026.33.3.2588
ISSN
1907-770X, 0215-6334
Terbit
2026-07-23
Penerbit
SEAMEO BIOTROP
Bahasa
en
Lisensi
creativecommons.org/licenses/by-nc-nd/4.0

Abstrak

ARTICLE HIGLIGHTSBusulfan can damage the liver by triggering oxidative stress Physalis angulata leaves show natural liver protective effects Extract reduced oxidative damage in liver tissue Liver structure improved after extract treatment Early treatment provided stronger liver protection than delayed useABSTRACTLiver disease is the leading cause of death worldwide, with drug-induced hepatotoxicity representing a major contributing factor. Busulfan, an anticancer drug used in chronic myeloid leukemia, is cytotoxic to proliferating cells and can induce liver injury. Physalis angulata L. (ground cherry) contains bioactive compounds with potential hepatoprotective properties. This study aimed to evaluate the protective effects of ethanol extract of Phyasalis angulata L. (EEPA) leaves on busulfan-induced liver damage in female Sprague–Dawley rats. Twenty-five rats were randomly divided into five groups: P1 (normal control), P2 (busulfan 40 mg/kg BW, single dose), P3 (extract 300 mg/kg BW, days 1–28), P4 (busulfan + extract, days 1–28), and P5 (busulfan + extract, days 14–28). Parameters assessed were alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the level of malondialdehyde (MDA) in liver, and liver histology. Data were analyzed using one-way analysis of variance (ANOVA) followed by a post hoc test. The results showed that Physalis angulata L. extract did not cause significant differences in the serum ALT and AST levels but significantly reduced the MDA concentrations and improved the liver histological architecture. Busulfan administration significantly decreased hepatocyte count and increased Kupffer and inflammatory cells, fatty degeneration, and necrosis. Early administration of the extract (P4) demonstrated stronger hepatoprotective effects compared with delayed administration (P5). These findings suggest that EEPA leaves exerts hepatoprotective effects against busulfan-induced liver injury in rats, likely through antioxidant activity, as evidenced by subsequent histological improvement, and highlighting its potential as a natural hepatoprotective agent.

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  • IPB University
  • Syarif Hidayatullah State Islamic University Jakarta
  • State University of Jakarta
  • Hasanuddin University
  • Sekolah Tinggi Agama Kristen Protestan Negeri Sentani
  • Universitas Halu Oleo
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Rekan penulisOrganisasiArtikel bersama
Ni Wayan Kurniani KarjaIPB University5
Mokhamad FahrudinIPB University5
Raden Iis ArifiantiniIPB University4
Agik SuprayogiIPB University3
Arindina MahendraIPB University3
Aryani SatyaningtijasIPB University3
Elsi RahmadhaniIPB University3
Ronald TariganIPB University3
Damiana Rita EkastutiIPB University3
I Ketut Mudite AdnyaneIPB University3
Arief BoedionoIPB University3
La Ode SumarlinSyarif Hidayatullah State Islamic University Jakarta2
Min RahminiwatiIPB University2
Rizal GusdinarIPB University2
Muhammad ElmanavieanSekolah Tinggi Agama Kristen Protestan Negeri Sentani2
Arifin Budiman NugrahaIPB University2
Aisyah Fidela SiregarIPB University1
Hajar HajarAfiliasi tidak diketahui1
Meyliana WulandariState University of Jakarta1
Iman SupriatnaIPB University1
Ita DjuwitaIPB University1
NurbariahIPB University1
Muhammad Ardiansyah NurdinHasanuddin University1
Huda Shalahudin DarusmanIPB University1
Bambang PurwantaraIPB University1
Hastuti HastutiIPB University1
Takdir SailiUniversitas Halu Oleo1
Srihadi AgungpriyonoIPB University1
Mohamad Agus SetiadiIPB University1
Peni Suprapti HardjosworoIPB University1
L. Hardi PrasetyoAfiliasi tidak diketahui1
Maijon PurbaAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.biotrop.org/index.php/biotropia/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">HEPATOPROTECTIVE EFFECT OF Physalis angulata L. LEAF ETHANOL EXTRACT AGAINST BUSULFAN-INDUCED LIVER DAMAGE IN FEMALE RATS</dc:title>
	<dc:creator xml:lang="en">Rahmadhani, Elsi</dc:creator>
	<dc:creator xml:lang="en">Sismin Satyaningtijas, Aryani</dc:creator>
	<dc:creator xml:lang="en">Rita Ekastuti, Damiana</dc:creator>
	<dc:creator xml:lang="en">Tarigan, Ronald</dc:creator>
	<dc:creator xml:lang="en">Mudite Adnyane, I Ketut</dc:creator>
	<dc:creator xml:lang="en">Mohamad, Kusdiantoro</dc:creator>
	<dc:creator xml:lang="en">Wahono Esthi Prasetyaningtyas</dc:creator>
	<dc:creator xml:lang="en">Sulistyana, Yanti</dc:creator>
	<dc:subject xml:lang="en">busulfan</dc:subject>
	<dc:subject xml:lang="en">hepatoprotector</dc:subject>
	<dc:subject xml:lang="en">Physalis angulata L.</dc:subject>
	<dc:subject xml:lang="en">rats</dc:subject>
	<dc:subject xml:lang="en">Hepatotoxicity</dc:subject>
	<dc:subject xml:lang="en">Natural product</dc:subject>
	<dc:description xml:lang="en">ARTICLE HIGLIGHTSBusulfan can damage the liver by triggering oxidative stress Physalis angulata leaves show natural liver protective effects Extract reduced oxidative damage in liver tissue Liver structure improved after extract treatment Early treatment provided stronger liver protection than delayed useABSTRACTLiver disease is the leading cause of death worldwide, with drug-induced hepatotoxicity representing a major contributing factor. Busulfan, an anticancer drug used in chronic myeloid leukemia, is cytotoxic to proliferating cells and can induce liver injury. Physalis angulata L. (ground cherry) contains bioactive compounds with potential hepatoprotective properties. This study aimed to evaluate the protective effects of ethanol extract of Phyasalis angulata L. (EEPA) leaves on busulfan-induced liver damage in female Sprague–Dawley rats. Twenty-five rats were randomly divided into five groups: P1 (normal control), P2 (busulfan 40 mg/kg BW, single dose), P3 (extract 300 mg/kg BW, days 1–28), P4 (busulfan + extract, days 1–28), and P5 (busulfan + extract, days 14–28). Parameters assessed were alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the level of malondialdehyde (MDA) in liver, and liver histology. Data were analyzed using one-way analysis of variance (ANOVA) followed by a post hoc test. The results showed that Physalis angulata L. extract did not cause significant differences in the serum ALT and AST levels but significantly reduced the MDA concentrations and improved the liver histological architecture. Busulfan administration significantly decreased hepatocyte count and increased Kupffer and inflammatory cells, fatty degeneration, and necrosis. Early administration of the extract (P4) demonstrated stronger hepatoprotective effects compared with delayed administration (P5). These findings suggest that EEPA leaves exerts hepatoprotective effects against busulfan-induced liver injury in rats, likely through antioxidant activity, as evidenced by subsequent histological improvement, and highlighting its potential as a natural hepatoprotective agent.</dc:description>
	<dc:publisher xml:lang="en">SEAMEO BIOTROP</dc:publisher>
	<dc:date>2026-07-23</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.biotrop.org/index.php/biotropia/article/view/2588</dc:identifier>
	<dc:identifier>10.11598/btb.2026.33.3.2588</dc:identifier>
	<dc:source xml:lang="en">BIOTROPIA; Vol. 33 No. 3 (2026): BIOTROPIA Vol. 33 No. 3 September 2026; 378 - 388</dc:source>
	<dc:source>1907-770X</dc:source>
	<dc:source>0215-6334</dc:source>
	<dc:source>10.11598/btb.2026.33.3.</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.biotrop.org/index.php/biotropia/article/view/2588/972</dc:relation>
	<dc:relation>https://journal.biotrop.org/index.php/biotropia/article/view/2588/973</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Elsi Rahmadhani, Aryani Sismin Satyaningtijas, Damiana Rita Ekastuti, Ronald Tarigan, I Ketut Mudite Adnyane, Kusdiantoro Mohamad, Wahono Esthi Prasetyaningtyas, Yanti Sulistyana</dc:rights>
	<dc:rights xml:lang="en">http://creativecommons.org/licenses/by-nc-nd/4.0</dc:rights>
</oai_dc:dc>