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Modeling CD4+ T cells and CTL response in HIV-1 infection with antiretroviral therapy

Communication in Biomathematical Sciences · Vol. 1 No. 2 (2018) · hlm. 100–109

DOI
10.5614/cbms.2018.1.2.3
ISSN
2549-2896
Terbit
2018-12-28
Penerbit
The Indonesian Bio-Mathematical Society
Bahasa
eng

Abstrak

The majority of an immune system infected by HIV (Human Immunodeficiency Virus) is CD4+ T cells. The HIV-1 transmission through cell to cell of CD4+ T cells supports the productive infection. On the other hand, infected CD4+ T cells stimulate cytotoxic T-lymphocytes cells to control HIV-1 infection. We develop and analyze a mathematical model incorporating the infection process through cell to cell contact of CD4+ T cells, CTL compartment and the combination of RTI and PI treatments. By means of the alternative reproduction ratio, it is analyzed the stability criteria and the existence of endemic equilibrium. Numerical simulations are presented to study the implication of the combination of RTI and PI therapy. The results indicate that RTI drug shows more significant effect in reducing HIV-1 infection compared to PI drug.

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24 penulis · 53 tautan kepenulisan bersama · 27 lintas organisasi

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  • Diponegoro University
  • Bandung Institute of Technology
  • Universitas Muhammadiyah Semarang
  • Universitas Gadjah Mada
  • Zayed University
  • Sunan Kalijaga State Islamic University Yogyakarta
  • Tadulako University
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Rekan penulisOrganisasiArtikel bersama
Etna VianitaDiponegoro University1
Muhammad Sam’anUniversitas Muhammadiyah Semarang1
A. Nafis HaikalDiponegoro University1
Ina Salamatul MufarichaUniversitas Gadjah Mada1
Titi UdjianiDiponegoro University1
Zani Anjani RafsanjaniDiponegoro University1
Ratna HerdianaDiponegoro University1
Yogi A. ErlanggaZayed University1
Revina Intan PraditaSunan Kalijaga State Islamic University Yogyakarta1
Juni Wijayanti PuspitaTadulako University1
Muhammad FakhruddinBandung Institute of Technology1
Hilda FahlenaBandung Institute of Technology1
Fatkhur RohimDiponegoro University1
Ervia YudiatiDiponegoro University1
Sri SejatiDiponegoro University1
Rani AgustianDiponegoro University1
Jusman RahimDiponegoro University1
Lilin BudiatiDiponegoro University1
Nuning NurainiBandung Institute of Technology1
Lisyani SuromoDiponegoro University1
Faraimunashe ChiroveUniversity of KwaZulu-Natal1

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Sumber metadata: OAI-PMH (metadata jurnal) http://journals.itb.ac.id/index.php/cbms/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Modeling CD4+ T cells and CTL response in HIV-1 infection with antiretroviral therapy</dc:title>
	<dc:creator>Sutimin, Sutimin</dc:creator>
	<dc:creator>Sunarsih, Sunarsih</dc:creator>
	<dc:creator>Tjahjana, R. Heru</dc:creator>
	<dc:subject xml:lang="en-US">HIV-1</dc:subject>
	<dc:subject xml:lang="en-US">CD4  T cells</dc:subject>
	<dc:subject xml:lang="en-US">CTL cells</dc:subject>
	<dc:subject xml:lang="en-US">RTI</dc:subject>
	<dc:subject xml:lang="en-US">PI.</dc:subject>
	<dc:description xml:lang="en-US">The majority of an immune system infected by HIV (Human Immunodeficiency Virus) is CD4+ T cells. The HIV-1 transmission through cell to cell of CD4+ T cells supports the productive infection. On the other hand, infected CD4+ T cells stimulate cytotoxic T-lymphocytes cells to control HIV-1 infection. We develop and analyze a mathematical model incorporating the infection process through cell to cell contact of CD4+ T cells, CTL compartment and the combination of RTI and PI treatments. By means of the alternative reproduction ratio, it is analyzed the stability criteria and the existence of endemic equilibrium. Numerical simulations are presented to study the implication of the combination of RTI and PI therapy. The results indicate that RTI drug shows more significant effect in reducing HIV-1 infection compared to PI drug.</dc:description>
	<dc:publisher xml:lang="en-US">The Indonesian Bio-Mathematical Society</dc:publisher>
	<dc:date>2018-12-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journals.itb.ac.id/index.php/cbms/article/view/9586</dc:identifier>
	<dc:identifier>10.5614/cbms.2018.1.2.3</dc:identifier>
	<dc:source xml:lang="en-US">Communication in Biomathematical Sciences; Vol. 1 No. 2 (2018); 100-109</dc:source>
	<dc:source>2549-2896</dc:source>
	<dc:source>10.5614/cbms.2018.1.2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journals.itb.ac.id/index.php/cbms/article/view/9586/3802</dc:relation>
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