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The crystal packing and slip plane analysis in mechanical properties improvement of mefenamic acid by cocrystallization with nicotinamide coformer

Communications in Science and Technology · Vol. 5 No. 2 (2020) · hlm. 93–97

DOI
10.21924/cst.5.2.2020.213
ISSN
2502-9266, 2502-9258
Terbit
2020-12-26
Penerbit
Komunitas Ilmuwan dan Profesional Muslim Indonesia
Bahasa
eng

Abstrak

Mefenamic acid is an analgesic non-steroidal anti-inflammatory drug (NSAID) that is categorized as Biopharmaceutical Classification System (BCS) class II drug. Cocrystallization of mefenamic acid (MFA) with nicotinamide (NIC) has been reported to enhance the solubility of MFA for about 2.56 times higher than pure MFA. As a part of MFA-NIC development in pharmaceutical dosage form, we reported the improvement of mechanical properties of MFA-NIC cocrystal based on the presence of slip planes in crystal structure. The research was initially by synthesizing and characterizing the cocrystal by using X-ray diffraction analysis, and was followed by the investigation of the mechanical properties of MFA and its cocrystal, i.e. tensile strength and deformation parameter. The correlation of crystal structure with mechanical properties was determined by crystal packing motif and slip plane analysis from single crystal data by using Mercury 3.6. The tensile strength of MFA was acceptance at 20.0 MPa, and dropped at more than 25.0 MPa. A better tableting performance was observed in MFA-NIC cocrystal which had the tensile strength 1.5 times higher than MFA at 12.5 MPa and gradually increased with an increasing pressure up to 2.5 times at 22.5 MPa. The flat slip plane of MFA-NIC cocrystal was predicted as the key factor in the improvement of its mechanical properties, compared to zigzag slip plane of MFA. In conclusion, MFA-NIC cocrystal had the better mechanical properties than pure MFA due to its flat slip plane and it becomes potential to be explored in further development of solid dosage form.

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  • Universitas Ahmad Dahlan
  • Muhammadiyah University of Yogyakarta
  • Universitas Muhammadiyah Banjarmasin
  • Universitas Islam Negeri Sulthan Thaha Saifuddin Jambi
  • Universitas Pendidikan Muhammadiyah Sorong
  • Iwaki City Medical Center
  • National Research and Innovation Agency
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Rekan penulisOrganisasiArtikel bersama
Akrom AkromUniversitas Ahmad Dahlan3
Titiek HidayatiMuhammadiyah University of Yogyakarta3
Andika AndikaUniversitas Islam Negeri Sulthan Thaha Saifuddin Jambi1
Nurkhasanah MahfudhUniversitas Ahmad Dahlan1
Mustofa AhdaUniversitas Ahmad Dahlan1
Siti NashihahUniversitas Muhammadiyah Banjarmasin1
Giriani Ayu SabillaUniversitas Ahmad Dahlan1
Lukman HardiaUniversitas Pendidikan Muhammadiyah Sorong1
Nurkhasanah NurkhasanahAfiliasi tidak diketahui1
Ikhwan Dahlan RaisAfiliasi tidak diketahui1
Prasasti BintarumIwaki City Medical Center1
Laela Hayu NuraniUniversitas Ahmad Dahlan1
Muslih AnwarNational Research and Innovation Agency1

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Sumber metadata: OAI-PMH (metadata jurnal) https://cst.kipmi.or.id/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">The crystal packing and slip plane analysis in mechanical properties improvement of mefenamic acid by cocrystallization with nicotinamide coformer </dc:title>
	<dc:creator>Ari Wahyudi </dc:creator>
	<dc:creator>Utami, Dwi</dc:creator>
	<dc:creator>Setianto , Arif Budi</dc:creator>
	<dc:subject xml:lang="en-US">mefenamic acid</dc:subject>
	<dc:subject xml:lang="en-US">cocrystal</dc:subject>
	<dc:subject xml:lang="en-US">mechanical properties</dc:subject>
	<dc:subject xml:lang="en-US">slip plane</dc:subject>
	<dc:description xml:lang="en-US">Mefenamic acid is an analgesic non-steroidal anti-inflammatory drug (NSAID) that is categorized as Biopharmaceutical Classification System (BCS) class II drug. Cocrystallization of mefenamic acid (MFA) with nicotinamide (NIC) has been reported to enhance the solubility of MFA for about 2.56 times higher than pure MFA. As a part of MFA-NIC development in pharmaceutical dosage form, we reported the improvement of mechanical properties of MFA-NIC cocrystal based on the presence of slip planes in crystal structure. The research was initially by synthesizing and characterizing the cocrystal by using X-ray diffraction analysis, and was followed by the investigation of the mechanical properties of MFA and its cocrystal, i.e. tensile strength and deformation parameter. The correlation of crystal structure with mechanical properties was determined by crystal packing motif and slip plane analysis from single crystal data by using Mercury 3.6. The tensile strength of MFA was acceptance at 20.0 MPa, and dropped at more than 25.0 MPa. A better tableting performance was observed in MFA-NIC cocrystal which had the tensile strength 1.5 times higher than MFA at 12.5 MPa and gradually increased with an increasing pressure up to 2.5 times at 22.5 MPa. The flat slip plane of MFA-NIC cocrystal was predicted as the key factor in the improvement of its mechanical properties, compared to zigzag slip plane of MFA. In conclusion, MFA-NIC cocrystal had the better mechanical properties than pure MFA due to its flat slip plane and it becomes potential to be explored in further development of solid dosage form.</dc:description>
	<dc:publisher xml:lang="en-US">Komunitas Ilmuwan dan Profesional Muslim Indonesia</dc:publisher>
	<dc:date>2020-12-26</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://cst.kipmi.or.id/journal/article/view/213</dc:identifier>
	<dc:identifier>10.21924/cst.5.2.2020.213</dc:identifier>
	<dc:source xml:lang="en-US">Communications in Science and Technology; Vol. 5 No. 2 (2020); 93-97</dc:source>
	<dc:source xml:lang="id-ID">Communications in Science and Technology; Vol 5 No 2 (2020); 93-97</dc:source>
	<dc:source>2502-9266</dc:source>
	<dc:source>2502-9258</dc:source>
	<dc:source>10.21924/cst.5.2.2020</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://cst.kipmi.or.id/journal/article/view/213/76</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Communications in Science and Technology</dc:rights>
</oai_dc:dc>