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Combined enzymatic and ultrasound-assisted aqueous two-phase extraction of antidiabetic flavonoid compounds from Strobilanthes crispus leaves

Communications in Science and Technology · Vol. 8 No. 2 (2023) · hlm. 113–123

DOI
10.21924/cst.8.2.2023.1214
ISSN
2502-9266, 2502-9258
Terbit
2023-12-31
Penerbit
Komunitas Ilmuwan dan Profesional Muslim Indonesia
Bahasa
eng

Abstrak

A novel green extraction method combining enzymatic and ultrasound-assisted aqueous two-phase extractions was employed to enhance and purify the flavonoid extract from Strobilanthes crispus leaves. Cellulase was used in the pretreatment, and ethanol-(NH4)2SO4 was selected as the solvent. A concentration of 7% (w/w) cellulase and a duration of 2 h were the optimal conditions for pretreatment. The optimal conditions for ultrasound-assisted aqueous two-phase extraction were 33% (w/w) ethanol and 14% (w/w) (NH4)2SO4 as they produced a yield (77.81%), partition coefficient (31.17), extraction efficiency (98.04%), and a high total flavonoid content (0.3666 mg QE/g dry leaf powder). Six compounds from the leaf extract were identified through liquid chromatography-mass spectrometry/mass spectrometry-quadrupole-time of flight (LCMS/MS-Q-TOF) analysis. The crude extract and three compounds in it (kaempferol, graveobioside A, and genistein) showed an antidiabetic activity with IC50 values of 390.35, 201.87, 292.73, and 431.82 mg/mL, respectively. These values are comparable to the standard drug acarbose.

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Reno PratiwiAfiliasi tidak diketahui2
RatnawatiAfiliasi tidak diketahui2
Eniya Listiani DewiAfiliasi tidak diketahui2
Nina OktarinaAfiliasi tidak diketahui1
Hilda HildaFitria WulandariAfiliasi tidak diketahui1
Hilda Fitria WulandariAfiliasi tidak diketahui1
Khusna Santika RahmasariAfiliasi tidak diketahui1
Achmad Vandian NurAfiliasi tidak diketahui1
Samsiar wicaksonoAfiliasi tidak diketahui1
MardhatillahAfiliasi tidak diketahui1
Shirly Rizki KusumaningrumAfiliasi tidak diketahui1
Muhammad IbadurrohmanAfiliasi tidak diketahui1
Eniya Listiani DewiAfiliasi tidak diketahui1
Calvin SantosoAfiliasi tidak diketahui1
Saddam HuseinPoliteknik Negeri Ujung Pandang1
Ryan Rafi RustamadjiAfiliasi tidak diketahui1
Ivander Jonathan KimAfiliasi tidak diketahui1
Aris Romadhon SubkhanAfiliasi tidak diketahui1
Rakha Putra PrasetyaAfiliasi tidak diketahui1
Tiur ElysabethAfiliasi tidak diketahui1
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Sumber metadata: OAI-PMH (metadata jurnal) https://cst.kipmi.or.id/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Combined enzymatic and ultrasound-assisted aqueous two-phase extraction of antidiabetic flavonoid compounds from Strobilanthes crispus leaves</dc:title>
	<dc:creator>Arbianti, Rita</dc:creator>
	<dc:creator>Angelina</dc:creator>
	<dc:creator>Suryapranata, Bryan</dc:creator>
	<dc:creator>Purwati Latifah, Linatri</dc:creator>
	<dc:creator>Fadilah Putri, Najah</dc:creator>
	<dc:creator>Surya Utami, Tania</dc:creator>
	<dc:creator>Muharam, Yuswan</dc:creator>
	<dc:creator>Slamet</dc:creator>
	<dc:subject xml:lang="en-US">Ultrasound</dc:subject>
	<dc:subject xml:lang="en-US">enzymatic</dc:subject>
	<dc:subject xml:lang="en-US">aqueous two-phase</dc:subject>
	<dc:subject xml:lang="en-US">S. crispus</dc:subject>
	<dc:subject xml:lang="en-US">antidiabetic</dc:subject>
	<dc:description xml:lang="en-US">A novel green extraction method combining enzymatic and ultrasound-assisted aqueous two-phase extractions was employed to enhance and purify the flavonoid extract from Strobilanthes crispus leaves. Cellulase was used in the pretreatment, and ethanol-(NH4)2SO4 was selected as the solvent. A concentration of 7% (w/w) cellulase and a duration of 2 h were the optimal conditions for pretreatment. The optimal conditions for ultrasound-assisted aqueous two-phase extraction were 33% (w/w) ethanol and 14% (w/w) (NH4)2SO4 as they produced a yield (77.81%), partition coefficient (31.17), extraction efficiency (98.04%), and a high total flavonoid content (0.3666 mg QE/g dry leaf powder). Six compounds from the leaf extract were identified through liquid chromatography-mass spectrometry/mass spectrometry-quadrupole-time of flight (LCMS/MS-Q-TOF) analysis. The crude extract and three compounds in it (kaempferol, graveobioside A, and genistein) showed an antidiabetic activity with IC50 values of 390.35, 201.87, 292.73, and 431.82 mg/mL, respectively. These values are comparable to the standard drug acarbose.</dc:description>
	<dc:publisher xml:lang="en-US">Komunitas Ilmuwan dan Profesional Muslim Indonesia</dc:publisher>
	<dc:date>2023-12-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://cst.kipmi.or.id/journal/article/view/1214</dc:identifier>
	<dc:identifier>10.21924/cst.8.2.2023.1214</dc:identifier>
	<dc:source xml:lang="en-US">Communications in Science and Technology; Vol. 8 No. 2 (2023); 113-123</dc:source>
	<dc:source xml:lang="id-ID">Communications in Science and Technology; Vol 8 No 2 (2023); 113-123</dc:source>
	<dc:source>2502-9266</dc:source>
	<dc:source>2502-9258</dc:source>
	<dc:source>10.21924/cst.8.2.2023</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://cst.kipmi.or.id/journal/article/view/1214/139</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Communications in Science and Technology</dc:rights>
</oai_dc:dc>