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Synthesis and characterization of hydroxyapatite/SiO2/gelatin composites as bone scaffold candidates

Communications in Science and Technology · Vol. 9 No. 1 (2024) · hlm. 16–24

DOI
10.21924/cst.9.1.2024.1350
ISSN
2502-9266, 2502-9258
Terbit
2024-07-12
Penerbit
Komunitas Ilmuwan dan Profesional Muslim Indonesia
Bahasa
eng

Abstrak

This study aims to determine the characteristics of hydroxyapatite/SiO2/gelatin composites to fulfil the bone scaffold standards. XRF analysis showed that limestone has a high CaO content of 92.89%, allowing it be used for hydroxyapatite synthesis. The wet precipitation method was used to synthesize hydroxyapatite; meanwhile, the freeze-drying method was used to synthesize the hydroxyapatite/SiO2/gelatin scaffold. FTIR analysis confirmed the characteristic peaks, which indicated the presence of compounds of hydroxyapatite (OH- and PO43-), SiO2 (Si-OH and Si-O-Si), and gelatin (N-H, C-H, and C=O). XRD analysis showed 98.1% hydroxyapatite phase and 1.9% SiO2 phase and SEM analysis showed a scaffold pore size of 155-218?m, optimal for cell attachment. Furthermore, mechanical testing resulted in a compressive strength of 1.71 MPa and porosity testing resulted in a porosity of 75%. This characterization showed the potential use of hydroxyapatite/SiO2/gelatin composites as bone scaffolds. This research can enable further development of scaffold materials in the field of tissue engineering.

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  • Hasanuddin University
  • Universitas Gadjah Mada
  • Universitas Islam Negeri Alauddin Makassar
  • Universitas Mandala Waluya
  • Universitas Megarezky
  • Afiliasi tidak diketahui
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Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Muḥammad Z̲ākirHasanuddin University8
Paulina TabaHasanuddin University7
Djabal Nur BasirHasanuddin University7
Rugaiyah A. ArfahHasanuddin University5
Nursiah La NafieHasanuddin University4
Siti KhairunnurHasanuddin University4
Nunuk Hariani SoekamtoHasanuddin University4
Ahyar AhmadHasanuddin University3
Abdur Rahman ArifHasanuddin University2
Maswati BaharuddinUniversitas Islam Negeri Alauddin Makassar2
Anwar DaudHasanuddin University2
Alimuddin Hamzah AssegafHasanuddin University2
Erwin Azizi JayadiprajaUniversitas Mandala Waluya2
Abdul Wahid WahabHasanuddin University2
Musa RamangHasanuddin University2
Abdul Wahid WahabAfiliasi tidak diketahui2
MamingAfiliasi tidak diketahui2
Abdul KarimAfiliasi tidak diketahui2
Triana FebriantiAfiliasi tidak diketahui2
Nuritasari AzisAfiliasi tidak diketahui2
Harningsih KarimAfiliasi tidak diketahui2
St Fauziah St FauziahAfiliasi tidak diketahui1
Prastawa BudiHasanuddin University1
S.J, SantosaUniversitas Gadjah Mada1
Sri SudionoUniversitas Gadjah Mada1
Fitriani BAfiliasi tidak diketahui1
Nur AsmiUniversitas Megarezky1
Ahyar AhmadAfiliasi tidak diketahui1
Harningsih KarimAfiliasi tidak diketahui1
Ali MuhakimAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://cst.kipmi.or.id/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Synthesis and characterization of hydroxyapatite/SiO2/gelatin composites as bone scaffold candidates </dc:title>
	<dc:creator>Wahda, Indah</dc:creator>
	<dc:creator>Syaharuddin Kasim</dc:creator>
	<dc:creator>Maming</dc:creator>
	<dc:creator>Hasnah Natsir</dc:creator>
	<dc:creator>St Fauziah</dc:creator>
	<dc:creator>Yusafir Hala</dc:creator>
	<dc:creator>Andi Muhammad Anshar</dc:creator>
	<dc:creator>Usman, Andriani</dc:creator>
	<dc:creator>Windasari</dc:creator>
	<dc:creator>Indah Raya</dc:creator>
	<dc:subject xml:lang="en-US">Limestone</dc:subject>
	<dc:subject xml:lang="en-US">hydroxyapatite/SiO2/gelatin</dc:subject>
	<dc:subject xml:lang="en-US">scaffold</dc:subject>
	<dc:description xml:lang="en-US">This study aims to determine the characteristics of hydroxyapatite/SiO2/gelatin composites to fulfil the bone scaffold standards. XRF analysis showed that limestone has a high CaO content of 92.89%, allowing it be used for hydroxyapatite synthesis. The wet precipitation method was used to synthesize hydroxyapatite; meanwhile, the freeze-drying method was used to synthesize the hydroxyapatite/SiO2/gelatin scaffold. FTIR analysis confirmed the characteristic peaks, which indicated the presence of compounds of hydroxyapatite (OH- and PO43-), SiO2 (Si-OH and Si-O-Si), and gelatin (N-H, C-H, and C=O). XRD analysis showed 98.1% hydroxyapatite phase and 1.9% SiO2 phase and SEM analysis showed a scaffold pore size of 155-218?m, optimal for cell attachment. Furthermore, mechanical testing resulted in a compressive strength of 1.71 MPa and porosity testing resulted in a porosity of 75%. This characterization showed the potential use of hydroxyapatite/SiO2/gelatin composites as bone scaffolds. This research can enable further development of scaffold materials in the field of tissue engineering.</dc:description>
	<dc:publisher xml:lang="en-US">Komunitas Ilmuwan dan Profesional Muslim Indonesia</dc:publisher>
	<dc:date>2024-07-12</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://cst.kipmi.or.id/journal/article/view/1350</dc:identifier>
	<dc:identifier>10.21924/cst.9.1.2024.1350</dc:identifier>
	<dc:source xml:lang="en-US">Communications in Science and Technology; Vol. 9 No. 1 (2024); 16-24</dc:source>
	<dc:source xml:lang="id-ID">Communications in Science and Technology; Vol 9 No 1 (2024); 16-24</dc:source>
	<dc:source>2502-9266</dc:source>
	<dc:source>2502-9258</dc:source>
	<dc:source>10.21924/cst.9.1.2024</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://cst.kipmi.or.id/journal/article/view/1350/155</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 Communications in Science and Technology</dc:rights>
</oai_dc:dc>