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Study on the cytotoxicity and chromosome aberration following implantation of sea coral in rabbits

Dental Journal (Majalah Kedokteran Gigi) · Vol. 39 No. 1 (2006) · hlm. 8–11

DOI
10.20473/j.djmkg.v39.i1.p8-11
ISSN
2442-9740, 1978-3728
Terbit
2006-03-01
Penerbit
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Bahasa
eng

Abstrak

Coral has been used as a bone substitute in many experimental studies. It has been proven to be biocompatible, biodegradable and easy to handle: and it has not been found to cause any inflammatory responses. The present study was undertaken to determine the cytotoxicity in terms of mitotic index as well as the clastogenic effect (chromosome aberration) of sea coral implantation in rabbits. The animals comprised of five male adult healthy New Zealand White (Oryctolagus cuniculus) rabbits. The biomaterial, sea coral granules used in this study was obtained from Porites species and processed by the tissue bank of Universiti Sains Malaysia, Health Campus, Kubang Kerian, Malaysia. The blood samples were collected twice from the rabbits, once before the implantation of the sea coral granules (which acted as the control) and the other, one week after the implantation (which acted as the treatment) and lymphocyte cultures were set up. The cultures were then harvested and the chromosomes were prepared for analysis. The diploid number of chromosomes in the rabbits (Oryctolagus cuniculus) was found to be 44. Mean mitotic indices of 3.84 ± 0.54 per cent and 3.76 ± 0.23 per cent were obtained before and after implantation of sea coral granules respectively. There were no structural or numerical chromosomal aberrations observed in both the cases. The mitotic index values and chromosomal analyses in this preliminary study carried out indicate that the biomaterial, sea coral granules is non-cytotoxic and non-clastogenic under the present test conditions.

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  • Universiti Sains Malaysia
  • Universiti Brunei Darussalam
  • Universitas Gadjah Mada
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Rekan penulisOrganisasiArtikel bersama
Mon Mon Tin‐OoUniversiti Sains Malaysia2
Roselinda AbusamahUniversiti Sains Malaysia2
Ema MulyawatiUniversitas Gadjah Mada1
Lin NaingUniversiti Brunei Darussalam1
Samsudin ArUniversiti Sains Malaysia1
Khamisah Awang KechikUniversiti Sains Malaysia1
M ShahrohishamUniversiti Sains Malaysia1
Ban Tawfeek Shareff Al AniAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Study on the cytotoxicity and chromosome aberration following implantation of sea coral in rabbits</dc:title>
	<dc:creator>TP, Kannan</dc:creator>
	<dc:creator>Tai Keat, Freeda Woon Faiza Woon</dc:creator>
	<dc:creator>Witjaksono, Widowati</dc:creator>
	<dc:creator>Samsudin, Abdul Rani</dc:creator>
	<dc:subject xml:lang="en-US">sea coral</dc:subject>
	<dc:subject xml:lang="en-US">cytotoxicity</dc:subject>
	<dc:subject xml:lang="en-US">chromosome aberration</dc:subject>
	<dc:description xml:lang="en-US">Coral has been used as a bone substitute in many experimental studies. It has been proven to be biocompatible, biodegradable and easy to handle: and it has not been found to cause any inflammatory responses. The present study was undertaken to determine the cytotoxicity in terms of mitotic index as well as the clastogenic effect (chromosome aberration) of sea coral implantation in rabbits. The animals comprised of five male adult healthy New Zealand White (Oryctolagus cuniculus) rabbits. The biomaterial, sea coral granules used in this study was obtained from Porites species and processed by the tissue bank of Universiti Sains Malaysia, Health Campus, Kubang Kerian, Malaysia. The blood samples were collected twice from the rabbits, once before the implantation of the sea coral granules (which acted as the control) and the other, one week after the implantation (which acted as the treatment) and lymphocyte cultures were set up. The cultures were then harvested and the chromosomes were prepared for analysis. The diploid number of chromosomes in the rabbits (Oryctolagus cuniculus) was found to be 44. Mean mitotic indices of 3.84 ± 0.54 per cent and 3.76 ± 0.23 per cent were obtained before and after implantation of sea coral granules respectively. There were no structural or numerical chromosomal aberrations observed in both the cases. The mitotic index values and chromosomal analyses in this preliminary study carried out indicate that the biomaterial, sea coral granules is non-cytotoxic and non-clastogenic under the present test conditions.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2006-03-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/1105</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v39.i1.p8-11</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 39 No. 1 (2006): March 2006; 8-11</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/1105/888</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2015 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
</oai_dc:dc>