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The effect of different concentrations of Neem (Azadiractha indica) leaves extract on the inhibition of Streptococcus mutans (In vitro)

Dental Journal (Majalah Kedokteran Gigi) · Vol. 38 No. 4 (2005) · hlm. 176–179

DOI
10.20473/j.djmkg.v38.i4.p176-179
ISSN
2442-9740, 1978-3728
Terbit
2005-12-01
Penerbit
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Bahasa
eng

Abstrak

The Neem plant has a history for treating gum and teeth problems and this plant is used for oral care in India. The active component (Azadirachta indica) has been proven to exhibit antibacterial properties. The objective of this study was to determine the influence of different concentrations of Neem leaves extract on the inhibition of Streptococcus mutans. Neem leaves extract at concentrations of 10%, 20%, 40%, 60%, 80%, and 100% was prepared. Fifty milliliters of each concentration were dropped into holes of 6 millimeters in diameter on a MHA agar that has been inoculated with Streptococcus mutans. Distilled water was used as a control. After 24 hours of incubation, the inhibition diameters were measured and analyzed. The statistical results of the one-way analysis of variance (ANOVA) illustrated that the different concentrations of Neem extract had a significant influence on the inhibition of Streptococcus mutans. This was followed with the Least Significant Difference (LSD) which implied that there were significant differences between all the concentrations of Neem leaves extract used in this experiment. The conclusion of this study was that Neem leaves extract exhibited antibacterial effect towards Streptococcus mutans and different concentration of Neem leaves extract influenced the inhibition of Streptococcus mutans.

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  • Universitas Gadjah Mada
  • Sumatera Institute of Technology
  • National Research and Innovation Agency
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Rekan penulisOrganisasiArtikel bersama
Dyah IrnawatiUniversitas Gadjah Mada5
Juni HandajaniUniversitas Gadjah Mada2
Ema MulyawatiUniversitas Gadjah Mada2
Nuryono NuryonoUniversitas Gadjah Mada2
HarsiniUniversitas Gadjah Mada2
WidjijonoUniversitas Gadjah Mada2
Mohammad Imanuddin YasnawiUniversitas Gadjah Mada2
Dhea Maurilla VeraniUniversitas Gadjah Mada2
Niswati Fathmah RosyidaUniversitas Gadjah Mada1
Pinandi Sri PudyaniUniversitas Gadjah Mada1
Marsetyawan H. N. E. SoesatyoUniversitas Gadjah Mada1
Archadian NuryantiUniversitas Gadjah Mada1
Dewi AgustinaUniversitas Gadjah Mada1
Widya AsmaraUniversitas Gadjah Mada1
Yulita KristantiUniversitas Gadjah Mada1
Marsetyawan HnesUniversitas Gadjah Mada1
Alizatul Khairani HasanUniversitas Gadjah Mada1
Tunjung NugraheniUniversitas Gadjah Mada1
Dyah Anindya WidyasriniUniversitas Gadjah Mada1
Wayan Tunas ArtamaUniversitas Gadjah Mada1
Sri Budi BarunawatiUniversitas Gadjah Mada1
Suparyono SalehUniversitas Gadjah Mada1
Yosi Bayu MurtiUniversitas Gadjah Mada1
Mariyam MariyamSumatera Institute of Technology1
Leny YuliatunNational Research and Innovation Agency1
Ismi KhuzaimahUniversitas Gadjah Mada1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">The effect of different concentrations of Neem (Azadiractha indica) leaves extract on the inhibition of Streptococcus mutans (In vitro)</dc:title>
	<dc:creator>Subramaniam, Sri Kavi</dc:creator>
	<dc:creator>Siswomihardjo, Widowati</dc:creator>
	<dc:creator>Sunarintyas, Siti</dc:creator>
	<dc:subject xml:lang="en-US">Azadirachta indica</dc:subject>
	<dc:subject xml:lang="en-US">Streptococcus mutans</dc:subject>
	<dc:subject xml:lang="en-US">antibacterial</dc:subject>
	<dc:description xml:lang="en-US">The Neem plant has a history for treating gum and teeth problems and this plant is used for oral care in India. The active component (Azadirachta indica) has been proven to exhibit antibacterial properties. The objective of this study was to determine the influence of different concentrations of Neem leaves extract on the inhibition of Streptococcus mutans. Neem leaves extract at concentrations of 10%, 20%, 40%, 60%, 80%, and 100% was prepared. Fifty milliliters of each concentration were dropped into holes of 6 millimeters in diameter on a MHA agar that has been inoculated with Streptococcus mutans. Distilled water was used as a control. After 24 hours of incubation, the inhibition diameters were measured and analyzed. The statistical results of the one-way analysis of variance (ANOVA) illustrated that the different concentrations of Neem extract had a significant influence on the inhibition of Streptococcus mutans. This was followed with the Least Significant Difference (LSD) which implied that there were significant differences between all the concentrations of Neem leaves extract used in this experiment. The conclusion of this study was that Neem leaves extract exhibited antibacterial effect towards Streptococcus mutans and different concentration of Neem leaves extract influenced the inhibition of Streptococcus mutans.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2005-12-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/1117</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v38.i4.p176-179</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 38 No. 4 (2005): December 2005; 176-179</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/1117/900</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2015 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
</oai_dc:dc>