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Synergistic effect of the combination of Cinnamomum burmanii, vigna unguiculata, and papain exracts derived from carica papaya latex against C. albicans biofilms degradation

Dental Journal (Majalah Kedokteran Gigi) · Vol. 49 No. 2 (2016) · hlm. 71–75

DOI
10.20473/j.djmkg.v49.i2.p71-75
ISSN
2442-9740, 1978-3728
Terbit
2016-06-30
Penerbit
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Bahasa
eng

Abstrak

Background: Candidiasis is an opportunistic infection commonly occurs on host with immunodeficiency, organ transplantation, leukopenia, or radiation therapy. Biofilms are structures that protect C. albicans from antifungals treatments. C. albicans biofilms display multidrug resistance to antifungal agents. Purpose: This study aimed to know whether the combination of Cinnamomum burmannii, Vigna unguiculata, and Papain extracts derived from Carica papaya latex has inadequate inhibitory effects against C.albicans biofilms compared to the combination of Cinnamomum burmannii and Vigna unguiculata extracts. Method: C. albicans. growing on SDA were dissolved in 1 McFarland of sterile aquadest. Micro-plate was filled with 180 µL of SDB, glucose 8%, and 20 µL of C. albicans. Suspension was incubated at 37oC overnight. Extracts were added and incubated for 24 hours. Then, each well was washed with distilled water, and stained with crystal violet 0.1% for 15 minutes. Afterward, each well was washed with distilled water and immediately stained with acetic acid. After 15 minutes of staining, the suspension was transferred to a new well, then measured with micro-plate reader at 595 nm. Results: The combination of Cinnamomum burmanii and Vigna unguiculata extracts had adequate inhibitory effects which is equal to 60.75%. Inhibition increased to 72.09%, 79.06%, and 79.50% after Papain derived from Carica papaya latex was added on concentrations of 138 mg/mL, 276 mg/mL, and 552 mg/mL. Conclusion: The combination of Cinnamomum burmanii (0.25µg/mL), Vigna unguiculata (200 µg/mL), and Papain (276 µg/mL) extracts showed an optimum synergic inhibition for C. albicans biofilms.

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Rekan penulisOrganisasiArtikel bersama
Deby Kania Tri PutriAfiliasi tidak diketahui2
Sitti Wahidah MasnaniHasanuddin University1
Mujadilah NurAfiliasi tidak diketahui1
Muhammad LuthfiAfiliasi tidak diketahui1
Sumarno SumarnoAfiliasi tidak diketahui1
Martien Herna SusantiAfiliasi tidak diketahui1
Herluinus Mafranenda DNAfiliasi tidak diketahui1
Ester Arijani RAfiliasi tidak diketahui1
Haryono UtomoAfiliasi tidak diketahui1
Diah Savitri ErnawatiAfiliasi tidak diketahui1
Retno IndrawatiAfiliasi tidak diketahui1
Erina Fatmala Yuli AndariAfiliasi tidak diketahui1
Tuti KusumaningsihAfiliasi tidak diketahui1
Ira ArundinaAfiliasi tidak diketahui1
Nizamiar HamniAfiliasi tidak diketahui1
Taufan BramantoroAfiliasi tidak diketahui1
Debby Syahru RomadlonAfiliasi tidak diketahui1
Elly MunadzirohAfiliasi tidak diketahui1
Moh. Basroni RizalAfiliasi tidak diketahui1
Indeswati DiyatriAfiliasi tidak diketahui1
Intan Amalia PutriAfiliasi tidak diketahui1
Retno Pudji RahayuAfiliasi tidak diketahui1
Christian KhoswantoAfiliasi tidak diketahui1
Aqsa Sjuhada OkiAfiliasi tidak diketahui1
Moch Febi AlviansyahAfiliasi tidak diketahui1
Ferdian Wira PratamaAfiliasi tidak diketahui1
Opi FauzanAfiliasi tidak diketahui1
Yaris Adhial FajrinAfiliasi tidak diketahui1
Hasnan BachtiarAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Synergistic effect of the combination of Cinnamomum burmanii, vigna unguiculata, and papain exracts derived from carica papaya latex against C. albicans biofilms degradation</dc:title>
	<dc:creator>Luthfi, Muhammad</dc:creator>
	<dc:creator>Kriswandini, Indah Listiana</dc:creator>
	<dc:creator>Zaba, Fitriah Hasan</dc:creator>
	<dc:subject xml:lang="en-US">C. albicans biofilm</dc:subject>
	<dc:subject xml:lang="en-US">Cinnamomum burmannii</dc:subject>
	<dc:subject xml:lang="en-US">Vigna unguiculata</dc:subject>
	<dc:subject xml:lang="en-US">Papain</dc:subject>
	<dc:description xml:lang="en-US">Background: Candidiasis is an opportunistic infection commonly occurs on host with immunodeficiency, organ transplantation, leukopenia, or radiation therapy. Biofilms are structures that protect C. albicans from antifungals treatments. C. albicans biofilms display multidrug resistance to antifungal agents. Purpose: This study aimed to know whether the combination of Cinnamomum burmannii, Vigna unguiculata, and Papain extracts derived from Carica papaya latex has inadequate inhibitory effects against C.albicans biofilms compared to the combination of Cinnamomum burmannii and Vigna unguiculata extracts. Method: C. albicans. growing on SDA were dissolved in 1 McFarland of sterile aquadest. Micro-plate was filled with 180 µL of SDB, glucose 8%, and 20 µL of C. albicans. Suspension was incubated at 37oC overnight. Extracts were added and incubated for 24 hours. Then, each well was washed with distilled water, and stained with crystal violet 0.1% for 15 minutes. Afterward, each well was washed with distilled water and immediately stained with acetic acid. After 15 minutes of staining, the suspension was transferred to a new well, then measured with micro-plate reader at 595 nm. Results: The combination of Cinnamomum burmanii and Vigna unguiculata extracts had adequate inhibitory effects which is equal to 60.75%. Inhibition increased to 72.09%, 79.06%, and 79.50% after Papain derived from Carica papaya latex was added on concentrations of 138 mg/mL, 276 mg/mL, and 552 mg/mL. Conclusion: The combination of Cinnamomum burmanii (0.25µg/mL), Vigna unguiculata (200 µg/mL), and Papain (276 µg/mL) extracts showed an optimum synergic inhibition for C. albicans biofilms.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2016-06-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/1360</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v49.i2.p71-75</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 49 No. 2 (2016): June 2016; 71-75</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/1360/2450</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
</oai_dc:dc>