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Effects of soy isoflavone genistein on orthodontic tooth movement in guinea pigs

Dental Journal (Majalah Kedokteran Gigi) · Vol. 49 No. 3 (2016) · hlm. 168–174

DOI
10.20473/j.djmkg.v49.i3.p168-174
ISSN
2442-9740, 1978-3728
Terbit
2016-09-30
Penerbit
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Bahasa
eng

Abstrak

Background: Osteoblast and osteoclast are the important factor in periodontal tissue remodeling for the orthodontic treatment success. Resorption process takes place in compression area by osteoclast and apposition in the tension area by osteoblast. In general hormone condition and age affect remodeling process. Estrogen has a high contribution in remodelling process and decreased in elderly individual such as menopausal women. Soybean contains isoflavone genistein which has similar structure and activity to estrogen. Many researchers indicate that isoflavone genistein not only has an inhibitor effect in osteoporosis but also has estrogenic and antiestrogenic effect as well. Purpose: The study aimed to investigate the effect of soybean isoflavone genistein administration on osteoblast and osteoclast cells number in orthodontic tooth movement of young and old guinea pigs. Method: The research was quasi-experimental study with post test only with control design. The experimental animals were 24 male guinea pigs that divided into: young guinea pigs (±4 months old) and old guinea pigs (±2.5 years old). Each group was divided into 4 subgroups for receiving the treatment namely; control, orthodontic treatment, genistein treatment and orthodontic+genistein treatment. All of the subjects were sacrificed at day 7 and the specimens were histologically analyzed using tartrate resistance acid phosphatase (TRAP) and hematoxylin eosin (HE) staining and observed using microscope that connected to obtilab and an image raster program. Result: U Mann-Whitney statistical analysis showed there were significant differences in osteoblast cell numbers; between orthodontic treatment and orthodontic+genistein treatment in the old guinea pigs (p=0.004); between orthodontic treatment in the young guinea pig and orthodontic+genistein treatment in the old guinea pig (p=0.016); between orthodontics treatment and orthodontic+genistein treatment in the young guinea pigs (p=0.025). U Mann-Whitney statistical analysis showed there were significant differences in osteoclast cell numbers: between the orthodontic treatment in the old guinea pig and orthodontics+genistein treatment in the young guinea pigs (p=0.007); between orthodontic treatment group in the young guinea pigs and orthodontics+genistein treatment in the old guinea pigs; between orthodontic treatment and orthodontic+ genistein treatment in the young guinea pigs (p=0.007). All groups administered by genistein the numbers of osteoblast in the surrounding of the tension sites increased, while in the surrounding of the compression sites had less osteoclasts; even, there were no osteoclasts found in some samples. Conclusion: Soybean isoflavone genistein administration on orthodontic tooth movement increased osteoblast numbers in the tension sides and decreased osteoclast numbers in the compression sides.

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  • Universitas Gadjah Mada
  • Muhammadiyah University of Yogyakarta
  • Duta Wacana Christian University
  • Universidade de Santiago de Compostela
  • Universitas Muhammadiyah Semarang
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Rekan penulisOrganisasiArtikel bersama
Ananto Ali AlhasyimiUniversitas Gadjah Mada3
Pamungkas Bagus SatriyoUniversitas Gadjah Mada2
Niswati Fathmah RosyidaUniversitas Gadjah Mada2
Siti SunarintyasUniversitas Gadjah Mada2
Marsetyawan H. N. E. SoesatyoUniversitas Gadjah Mada2
Widya AsmaraUniversitas Gadjah Mada2
Darmawan SutantyoUniversitas Gadjah Mada2
Wasito WasitoUniversitas Gadjah Mada2
Al SupartinahUniversitas Gadjah Mada2
Bramita Beta ArnandaUniversitas Gadjah Mada2
Dyah KaruniaUniversitas Gadjah Mada2
Andi TriawanUniversitas Gadjah Mada1
SismindariUniversitas Gadjah Mada1
Archadian NuryantiUniversitas Gadjah Mada1
Nolista Indah RasyidUniversitas Gadjah Mada1
Jcp HeryumaniUniversitas Gadjah Mada1
Ika Dewi AnaUniversitas Gadjah Mada1
Tita Ratya UtariMuhammadiyah University of Yogyakarta1
Yenni HanimastutiUniversitas Gadjah Mada1
Yanti LeosariUniversitas Gadjah Mada1
Sri HadiatiUniversitas Gadjah Mada1
Setiarini WidiarsantiUniversitas Gadjah Mada1
Fitria AvriliyantiUniversitas Gadjah Mada1
Heni SusilowatiUniversitas Gadjah Mada1
Suryani HutomoDuta Wacana Christian University1
Elfira MaharaniUniversitas Gadjah Mada1
Cendrawasih Andusyana FarmasyantiUniversitas Gadjah Mada1
Annisa Nurul FikriUniversitas Gadjah Mada1
Gufa Bagus PamungkasUniversitas Gadjah Mada1
Diatri Nari RatihUniversitas Gadjah Mada1
Francisco José Vázquez-SantosUniversidade de Santiago de Compostela1
Ryza YashaUniversitas Gadjah Mada1
Sarah Fitria RomadhoniUniversitas Gadjah Mada1
Hasna Syifa YunivaUniversitas Gadjah Mada1
Aprilia Indra KartikaUniversitas Muhammadiyah Semarang1
Siti Nur ChasanahUniversitas Gadjah Mada1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Effects of soy isoflavone genistein on orthodontic tooth movement in guinea pigs</dc:title>
	<dc:creator>Suparwitri, Sri</dc:creator>
	<dc:creator>Pudyani, Pinandi Sri</dc:creator>
	<dc:creator>Haryana, Sofia Mubarika</dc:creator>
	<dc:creator>Agustina, Dewi</dc:creator>
	<dc:subject xml:lang="en-US">isoflavone genistein of soybean</dc:subject>
	<dc:subject xml:lang="en-US">guinea pig</dc:subject>
	<dc:subject xml:lang="en-US">orthodontic tooth movement</dc:subject>
	<dc:description xml:lang="en-US">Background: Osteoblast and osteoclast are the important factor in periodontal tissue remodeling for the orthodontic treatment success. Resorption process takes place in compression area by osteoclast and apposition in the tension area by osteoblast. In general hormone condition and age affect remodeling process. Estrogen has a high contribution in remodelling process and decreased in elderly individual such as menopausal women. Soybean contains isoflavone genistein which has similar structure and activity to estrogen. Many researchers indicate that isoflavone genistein not only has an inhibitor effect in osteoporosis but also has estrogenic and antiestrogenic effect as well. Purpose: The study aimed to investigate the effect of soybean isoflavone genistein administration on osteoblast and osteoclast cells number in orthodontic tooth movement of young and old guinea pigs. Method: The research was quasi-experimental study with post test only with control design. The experimental animals were 24 male guinea pigs that divided into: young guinea pigs (±4 months old) and old guinea pigs (±2.5 years old). Each group was divided into 4 subgroups for receiving the treatment namely; control, orthodontic treatment, genistein treatment and orthodontic+genistein treatment. All of the subjects were sacrificed at day 7 and the specimens were histologically analyzed using tartrate resistance acid phosphatase (TRAP) and hematoxylin eosin (HE) staining and observed using microscope that connected to obtilab and an image raster program. Result: U Mann-Whitney statistical analysis showed there were significant differences in osteoblast cell numbers; between orthodontic treatment and orthodontic+genistein treatment in the old guinea pigs (p=0.004); between orthodontic treatment in the young guinea pig and orthodontic+genistein treatment in the old guinea pig (p=0.016); between orthodontics treatment and orthodontic+genistein treatment in the young guinea pigs (p=0.025). U Mann-Whitney statistical analysis showed there were significant differences in osteoclast cell numbers: between the orthodontic treatment in the old guinea pig and orthodontics+genistein treatment in the young guinea pigs (p=0.007); between orthodontic treatment group in the young guinea pigs and orthodontics+genistein treatment in the old guinea pigs; between orthodontic treatment and orthodontic+ genistein treatment in the young guinea pigs (p=0.007). All groups administered by genistein the numbers of osteoblast in the surrounding of the tension sites increased, while in the surrounding of the compression sites had less osteoclasts; even, there were no osteoclasts found in some samples. Conclusion: Soybean isoflavone genistein administration on orthodontic tooth movement increased osteoblast numbers in the tension sides and decreased osteoclast numbers in the compression sides.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2016-09-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/2011</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v49.i3.p168-174</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 49 No. 3 (2016): September 2016; 168-174</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/2011/2535</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
</oai_dc:dc>