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The amount of macrophages and activated plasma cells on wound healing process affected by spirulina

Dental Journal (Majalah Kedokteran Gigi) · Vol. 48 No. 4 (2015) · hlm. 209–212

DOI
10.20473/j.djmkg.v48.i4.p209-212
ISSN
2442-9740, 1978-3728
Terbit
2015-12-31
Penerbit
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Bahasa
eng

Abstrak

Background: Spirulina which grows abundantly in tropical seas have been investigated to enhance immune system. The administration of spirulina in tooth extraction sockets was expected to optimise the function of immunocompetent cells. Therefore, wound healing process would be improved. Purpose: The aim of this study was to prove that administration of spirulina could influence immune system in tooth extraction sockets. Method: There were 28 Cavia cobayas used in this study and were put in group of four. Mandibular left incisive were extracted from each of them. The basis made from mixture of polyethylene glycol (PEG) 400 and PEG 4000 was administrated into each socket in control group (TG0). In addition, spirulina 12% was administrated into group TG1, spirulina 24% was administrated into group TG2, and spirulina 48% was administrated into group TG3. All of the Cavia cobaya were decapitated and the jaws were removed in day 5 after tooth extraction. The jaws were decalcified in EDTA solution, formed into paraffin block, processed for hematoxylin and eosin (H & E) and immunohistochemistry staining afterwards. Datas were analysed statistically using Anova method. Result: There was an augmentation in the number of macrophages and activated plasma cells after spirulina application. The administration of higher concentrations of Spirulina leads to greater amount of macrophages and activated plasma cells in each groups. Conclusion: In conclusion, spirulina is able to increase the amount of macrophages and activated plasma cells which play important role in healing process.

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  • Universitas Airlangga
  • Universitas Hang Tuah
  • Lambung Mangkurat University
  • Universitas Jember
  • State University of Semarang
  • Institut Ilmu Kesehatan Bhakti Wiyata
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Rekan penulisOrganisasiArtikel bersama
Meircurius Dwi Condro SurboyoUniversitas Airlangga4
Utari KresnoadiUniversitas Airlangga3
Diah Savitri ErnawatiUniversitas Airlangga3
Muhammad LuthfiUniversitas Airlangga3
Maharani Laillyza ApriasariLambung Mangkurat University2
Pratiwi SoesilawatiUniversitas Airlangga2
Titiek BerniyantiUniversitas Airlangga2
Agung SosiawanUniversitas Airlangga2
Elly MunadzirohUniversitas Airlangga2
Ardyni Febri KUniversitas Airlangga1
Sri HernawatiUniversitas Jember1
Fedik Abdul RantamUniversitas Airlangga1
I Ketut SudianaUniversitas Airlangga1
Imelda Kristina SutrisnoUniversitas Airlangga1
Tantiana TantianaUniversitas Airlangga1
Yuliati YuliatiState University of Semarang1
Dian Widya DamaiyantiUniversitas Hang Tuah1
Dania MaharaniUniversitas Airlangga1
Kharinna WidowatiUniversitas Hang Tuah1
Agni Febrina PargaputriUniversitas Hang Tuah1
Erina Fatmala Yuli AndariUniversitas Airlangga1
Fitria RahmitasariUniversitas Hang Tuah1
Nizamiar HamniUniversitas Airlangga1
Wahyu Aji WibowoUniversitas Airlangga1
Retno Indrawati RoestamadjiUniversitas Airlangga1
Puspa Dila RohmaniarInstitut Ilmu Kesehatan Bhakti Wiyata1
Maretaningtias Dwi ArianiUniversitas Airlangga1
Saka WiniasUniversitas Airlangga1
Rima Parwati SariUniversitas Hang Tuah1
Syamsulina ReviantiUniversitas Hang Tuah1
Widyasri PrananingrumUniversitas Hang Tuah1
Sri Agus SudjarwoUniversitas Airlangga1
Hansen KurniawanUniversitas Hang Tuah1
Aisah Faiz BachmidUniversitas Hang Tuah1
Imam Safari AzharUniversitas Airlangga1
Aqsa Sjuhada OkiUniversitas Airlangga1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The amount of macrophages and activated plasma cells on wound healing process affected by spirulina</dc:title>
	<dc:creator>Iskandar, Regina Purnama Dewi</dc:creator>
	<dc:creator>Indrawati, Retno</dc:creator>
	<dc:creator>Arundina, Ira</dc:creator>
	<dc:creator>Rahayu, Retno Pudji</dc:creator>
	<dc:subject xml:lang="en-US">spirulina</dc:subject>
	<dc:subject xml:lang="en-US">macrophages</dc:subject>
	<dc:subject xml:lang="en-US">plasma cells</dc:subject>
	<dc:description xml:lang="en-US">Background: Spirulina which grows abundantly in tropical seas have been investigated to enhance immune system. The administration of spirulina in tooth extraction sockets was expected to optimise the function of immunocompetent cells. Therefore, wound healing process would be improved. Purpose: The aim of this study was to prove that administration of spirulina could influence immune system in tooth extraction sockets. Method: There were 28 Cavia cobayas used in this study and were put in group of four. Mandibular left incisive were extracted from each of them. The basis made from mixture of polyethylene glycol (PEG) 400 and PEG 4000 was administrated into each socket in control group (TG0). In addition, spirulina 12% was administrated into group TG1, spirulina 24% was administrated into group TG2, and spirulina 48% was administrated into group TG3. All of the Cavia cobaya were decapitated and the jaws were removed in day 5 after tooth extraction. The jaws were decalcified in EDTA solution, formed into paraffin block, processed for hematoxylin and eosin (H &amp;amp; E) and immunohistochemistry staining afterwards. Datas were analysed statistically using Anova method. Result: There was an augmentation in the number of macrophages and activated plasma cells after spirulina application. The administration of higher concentrations of Spirulina leads to greater amount of macrophages and activated plasma cells in each groups. Conclusion: In conclusion, spirulina is able to increase the amount of macrophages and activated plasma cells which play important role in healing process.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2015-12-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/2219</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v48.i4.p209-212</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 48 No. 4 (2015): December 2015; 209-212</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/2219/1688</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2016 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
</oai_dc:dc>