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Inhibitory effect of jengkol leaf (Pithecellobium jiringa) extract to inhibit Candida albicans biofilm

Dental Journal (Majalah Kedokteran Gigi) · Vol. 49 No. 3 (2016) · hlm. 148–152

DOI
10.20473/j.djmkg.v49.i3.p148-152
ISSN
2442-9740, 1978-3728
Terbit
2016-09-30
Penerbit
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Bahasa
eng

Abstrak

Background: Candida albicans (C. albicans) are dimorphic fungi in oral cavity, considered not only as normal flora, but also as pathogens. C. albicans have an ability to grow biofilm, which has a thick layer of outer skin structure, called as extracellular matrix. Jengkol leaves (Pithecellobium jiringa) contain alkaloids, flavonoids, terpenoids, and lectins, which have an ability as antifungal agent Purpose: This study aimed to analyze the optimum dose of jengkol leaf extract as antibiofilm against C. albicans biofilms. Method: C. albicans were cultured on yeast peptone dextrosa (YPD) media in 96-well microtiter plate flat bottom plates. There were one control group (without treatment) and three treatment groups. The first treatment group was given jengkol leaf extract at a dose of 100 mg/ ml. The second treatment group was given jengkol leaf extract at a dose of 200 mg/ ml. And, the third treatment group was given jengkol leaf extract at a dose of 400 mg/ ml. Semi quantitative method was applied to determine C. albicans biofilmsis using Crystal Violet staining technique. The absorbance of the cells then was calculated using a spectrophotometer with a wavelength of 570 nm. Result: The mean value of optical density in the control group was 1.23. The mean value of optical density in the treatment group with a dose of 100 mg/ ml was 0.2. Meanwhile, the mean value of optical density in the treatment group with a dose of 200 mg/ ml was 0.2, and 0.21 in the treatment group with a dose of 400 mg/ ml. The results also showed that there were significant differences between the control group and all of the treatment groups (p 0.05). Conclusion: The optimum dose of jengkol leaf extract used as antibiofilm against C. albicans biofilms is 100 mg /ml with an inhibitory percentage of 83.7%.

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  • Universitas Airlangga
  • State University of Semarang
  • Universitas Hang Tuah
  • Lambung Mangkurat University
  • Poltekkes Kemenkes Malang
  • Taiz University
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Rekan penulisOrganisasiArtikel bersama
Retno Pudji RahayuUniversitas Airlangga3
Meircurius Dwi Condro SurboyoUniversitas Airlangga2
Indah Listiana KriswandiniUniversitas Airlangga2
Pratiwi SoesilawatiUniversitas Airlangga2
Retno IndrawatiUniversitas Airlangga2
Agung SosiawanUniversitas Airlangga1
Imelda Kristina SutrisnoUniversitas Airlangga1
Tantiana TantianaUniversitas Airlangga1
Fitriah Hasan ZabaUniversitas Airlangga1
Yuliati YuliatiState University of Semarang1
Dian Widya DamaiyantiUniversitas Hang Tuah1
Dania MaharaniUniversitas Airlangga1
Erina Fatmala Yuli AndariUniversitas Airlangga1
Regina Purnama Dewi IskandarUniversitas Airlangga1
Tuti KusumaningsihUniversitas Airlangga1
Deby Kania Tri PutriLambung Mangkurat University1
Taufan BramantoroUniversitas Airlangga1
Debby Syahru RomadlonPoltekkes Kemenkes Malang1
Christian KhoswantoUniversitas Airlangga1
Aqsa Sjuhada OkiUniversitas Airlangga1
Moch. Febi AlviansyahUniversitas Airlangga1
Ester Arijani RachmatUniversitas Airlangga1
Nita NaomiUniversitas Airlangga1
Anis IrmawatiUniversitas Airlangga1
Lia Aulia RachmaUniversitas Airlangga1
Sidarningsih SidarningsihUniversitas Airlangga1
Muhammad Naufal HattaUniversitas Airlangga1
Mohammed AljunaidTaiz University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Inhibitory effect of jengkol leaf (Pithecellobium jiringa) extract to inhibit Candida albicans biofilm</dc:title>
	<dc:creator>Luthfi, Muhammad</dc:creator>
	<dc:creator>Arundina, Ira</dc:creator>
	<dc:creator>Hamni, Nizamiar</dc:creator>
	<dc:subject xml:lang="en-US">jengkol leaf extract</dc:subject>
	<dc:subject xml:lang="en-US">antibiofilm</dc:subject>
	<dc:subject xml:lang="en-US">Candida albicans</dc:subject>
	<dc:description xml:lang="en-US">Background: Candida albicans (C. albicans) are dimorphic fungi in oral cavity, considered not only as normal flora, but also as pathogens. C. albicans have an ability to grow biofilm, which has a thick layer of outer skin structure, called as extracellular matrix. Jengkol leaves (Pithecellobium jiringa) contain alkaloids, flavonoids, terpenoids, and lectins, which have an ability as antifungal agent Purpose: This study aimed to analyze the optimum dose of jengkol leaf extract as antibiofilm against C. albicans biofilms. Method: C. albicans were cultured on yeast peptone dextrosa (YPD) media in 96-well microtiter plate flat bottom plates. There were one control group (without treatment) and three treatment groups. The first treatment group was given jengkol leaf extract at a dose of 100 mg/ ml. The second treatment group was given jengkol leaf extract at a dose of 200 mg/ ml. And, the third treatment group was given jengkol leaf extract at a dose of 400 mg/ ml. Semi quantitative method was applied to determine C. albicans biofilmsis using Crystal Violet staining technique. The absorbance of the cells then was calculated using a spectrophotometer with a wavelength of 570 nm. Result: The mean value of optical density in the control group was 1.23. The mean value of optical density in the treatment group with a dose of 100 mg/ ml was 0.2. Meanwhile, the mean value of optical density in the treatment group with a dose of 200 mg/ ml was 0.2, and 0.21 in the treatment group with a dose of 400 mg/ ml. The results also showed that there were significant differences between the control group and all of the treatment groups (p&amp;lt;0.05), but there was no significant difference between the treatment groups (p&amp;gt;0.05). Conclusion: The optimum dose of jengkol leaf extract used as antibiofilm against C. albicans biofilms is 100 mg /ml with an inhibitory percentage of 83.7%.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2016-09-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/3210</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v49.i3.p148-152</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 49 No. 3 (2016): September 2016; 148-152</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/3210/2536</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
</oai_dc:dc>