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The increase of VEGF expressions and new blood vessels formation in Wistar rats induced with post-tooth extraction sponge amnion

Dental Journal (Majalah Kedokteran Gigi) · Vol. 51 No. 1 (2018) · hlm. 1–4

DOI
10.20473/j.djmkg.v51.i1.p1-4
ISSN
2442-9740, 1978-3728
Terbit
2018-03-31
Penerbit
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Bahasa
eng

Abstrak

Background: Tooth extraction is the process of removing a tooth from the oral cavity potentially triggering a wound healing response in the body. As a result, many methods have been applied to improve the wound healing process, especially in wounds resulting in complications. One such method involves the application of amniotic membrane which has anti-inflammatory, anti-bacterial, anti-fibrosis, anti-scarring properties with low immunogenicity, epithelialization effects, and secretory leukocyte protease inhibitor (SLPI). It also contains collagen, various growth factors, transferrin, fibronectin, nidogen, proteoglycans, hyaluronan, and laminin. Purpose: This study aimed to determine the effects of sponge amnion on the number of VEGF expressions and new blood vessels in post-tooth extraction wounds of Wistar rats. Methods: Sponge amnion was produced by mixing freeze-dried amnion membrane from the Tissue Bank at RSUD Dr. Soetomo with 1% gelatin before freeze drying the mixture. Wistar rats were then divided into two groups. In Group 1, referred to as the control group, the post-extraction wounds of the rats received no treatment. Meanwhile, in Group 2, the treatment group, the subjects' post-extraction wounds were treated with sponge amnion. The rats of both groups were sacrificed on day 3 to allow observation of the number of VEGF expressions and new blood vessels. A statistical analysis test, a t-test, was subsequently conducted. Results: There was a significant difference in the number of new blood vessels in the control group and that of the treatment group with a p value of 0.018 (p<0.05). There was also a significant difference in VEGF expression between the two groups with a p value of 0.000 (p <0.05). Conclusion: Sponge amnion can generate a number of VEGF expressions and new blood vessels in the post-extraction wounds of Wistar rats.

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  • Universitas Airlangga
  • Universitas Hang Tuah
  • Lambung Mangkurat University
  • University of Malaya
  • University of Technology Malaysia
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Rekan penulisOrganisasiArtikel bersama
Muhammad LuthfiUniversitas Airlangga2
Devi RiantiUniversitas Airlangga2
Anita YuliatiUniversitas Airlangga2
Titien Hary AgustantinaUniversitas Airlangga2
Marchella Hendrayanti WUniversitas Airlangga1
Herluinus Mafranenda DNUniversitas Airlangga1
Ester Arijani RUniversitas Airlangga1
Haryono UtomoUniversitas Airlangga1
Diah Savitri ErnawatiUniversitas Airlangga1
David DavidUniversitas Airlangga1
Fitriah Hasan ZabaUniversitas Airlangga1
Agni Febrina PargaputriUniversitas Hang Tuah1
Retno IndrawatiUniversitas Airlangga1
Retno Pudji RahayuUniversitas Airlangga1
Fitria RahmitasariUniversitas Hang Tuah1
Deby Kania Tri PutriLambung Mangkurat University1
Intan Fajrin ArsyadaUniversitas Airlangga1
Indeswati DiyatriUniversitas Airlangga1
Intan Amalia PutriUniversitas Airlangga1
OctarinaAfiliasi tidak diketahui1
Muhammad Riza Hafidz BahtiarUniversitas Airlangga1
Rizki Fauziah SalmaUniversitas Airlangga1
Ajeng Putri MeyrantiUniversitas Airlangga1
Fathilah Binti Abdul RazakUniversity of Malaya1
FaradillahUniversitas Airlangga1
Asti MeizariniUniversitas Airlangga1
Alqomariyah Eka PurnamasariUniversitas Airlangga1
Rifayinqa Ruyani PutriUniversitas Airlangga1
Noor Zain Salsabilla PrabowoUniversitas Airlangga1
Ardiyansyah SyahromUniversity of Technology Malaysia1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The increase of VEGF expressions and new blood vessels formation in Wistar rats induced with post-tooth extraction sponge amnion</dc:title>
	<dc:creator>Rizal, Moh. Basroni</dc:creator>
	<dc:creator>Munadziroh, Elly</dc:creator>
	<dc:creator>Kriswandini, Indah Listiana</dc:creator>
	<dc:subject xml:lang="en-US">sponge amnion</dc:subject>
	<dc:subject xml:lang="en-US">angiogenesis</dc:subject>
	<dc:subject xml:lang="en-US">socket healing</dc:subject>
	<dc:subject xml:lang="en-US">VEGF expressions</dc:subject>
	<dc:description xml:lang="en-US">Background: Tooth extraction is the process of removing a tooth from the oral cavity potentially triggering a wound healing response in the body. As a result, many methods have been applied to improve the wound healing process, especially in wounds resulting in complications. One such method involves the application of amniotic membrane which has anti-inflammatory, anti-bacterial, anti-fibrosis, anti-scarring properties with low immunogenicity, epithelialization effects, and secretory leukocyte protease inhibitor (SLPI). It also contains collagen, various growth factors, transferrin, fibronectin, nidogen, proteoglycans, hyaluronan, and laminin. Purpose: This study aimed to determine the effects of sponge amnion on the number of VEGF expressions and new blood vessels in post-tooth extraction wounds of Wistar rats. Methods: Sponge amnion was produced by mixing freeze-dried amnion membrane from the Tissue Bank at RSUD Dr. Soetomo with 1% gelatin before freeze drying the mixture. Wistar rats were then divided into two groups. In Group 1, referred to as the control group, the post-extraction wounds of the rats received no treatment. Meanwhile, in Group 2, the treatment group, the subjects' post-extraction wounds were treated with sponge amnion. The rats of both groups were sacrificed on day 3 to allow observation of the number of VEGF expressions and new blood vessels. A statistical analysis test, a t-test, was subsequently conducted. Results: There was a significant difference in the number of new blood vessels in the control group and that of the treatment group with a p value of 0.018 (p&amp;lt;0.05). There was also a significant difference in VEGF expression between the two groups with a p value of 0.000 (p &amp;lt;0.05). Conclusion: Sponge amnion can generate a number of VEGF expressions and new blood vessels in the post-extraction wounds of Wistar rats.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2018-03-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/4491</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v51.i1.p1-4</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 51 No. 1 (2018): March 2018; 1-4</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/4491/4903</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
</oai_dc:dc>