Melola Discovery

← Melola Discovery

Jurnal SINTA 1

Potency of Garcinia mangostana L peel extract combined with demineralized freeze-dried bovine bone xenograft on IL-1β expression, osteoblasts, and osteoclasts in alveolar bone

Dental Journal (Majalah Kedokteran Gigi) · Vol. 50 No. 3 (2017) · hlm. 166–170

DOI
10.20473/j.djmkg.v50.i3.p166-170
ISSN
2442-9740, 1978-3728
Terbit
2017-09-30
Penerbit
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Bahasa
eng

Abstrak

Background: Alveolar bone plays an important role in supporting dentures. One socket preservation procedure is the application of bone graft to the tooth socket immediately after extraction. The administration of Garcinia mangostana L peel extract combined with demineralized freeze-dried bovine bone xenograft (DFDBBX) is assumed to decrease the number of osteoclast cells and IL-1β expressions, while also increasing that of osteoblast cells. Purpose: This study aimed to establish the potency of Garcinia mangostana L peel extract combined with DFDBBX on interleukin 1β expressions, osteoclast cells, and osteoblast cells during the preservation of tooth extraction sockets. Methods: This research constituted experimental laboratory-based research using 56 Cavia cobayas as specimens with randomized factorial design (true experimental design). These subjects were divided into eight groups, given PEG, DFDBBX, mangosteen peel extract or a combination of mangosteen peel extract and DFDBBX, and subsequently anesthesized before their left mandibular incisors were extracted. Thereafter, the post-extraction sockets were treated with PEG, DFDBBX, mangosteen peel extract or a combination of mangosteen peel extract and DFDBBX. The sockets were examined by means of HE and immunohistochemical staining on days 7 and 30 after extraction. The data obtained was analyzed with a one-way ANOVA test. Results: The results of the one-way ANOVA test showed that the average number of osteoblasts, osteoclasts, and IL-1β expressions varied significantly between the groups. Conclusion: The combination of mangosteen peel extract and DFDBBX can potentially increase osteoblasts, while also decreasing osteoclasts and IL-1β expressions in the alveolar bones of Cavia cobaya.

Kata kunci

Jaringan kolaborasi para penulis

40 penulis · 87 tautan kepenulisan bersama · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Universitas Pendidikan Ganesha
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Diah Savitri ErnawatiAfiliasi tidak diketahui3
Maharani Laillyza ApriasariAfiliasi tidak diketahui2
Titiek BerniyantiAfiliasi tidak diketahui2
Ira ArundinaAfiliasi tidak diketahui2
Meircurius Dwi Condro SurboyoAfiliasi tidak diketahui2
I Ketut SudianaUniversitas Pendidikan Ganesha2
Ardyni Febri KAfiliasi tidak diketahui1
Agung SosiawanAfiliasi tidak diketahui1
Sri HernawatiAfiliasi tidak diketahui1
Fedik Abdul RantamAfiliasi tidak diketahui1
Eha DjulaehaAfiliasi tidak diketahui1
Arif RachmanAfiliasi tidak diketahui1
Rostiny RostinyAfiliasi tidak diketahui1
Waloejo NoegrohoAfiliasi tidak diketahui1
Adi SubiantoAfiliasi tidak diketahui1
Kharinna WidowatiAfiliasi tidak diketahui1
Retno IndrawatiAfiliasi tidak diketahui1
Regina Purnama Dewi IskandarAfiliasi tidak diketahui1
Yurike HadisoesantoAfiliasi tidak diketahui1
Harly PrabowoAfiliasi tidak diketahui1
Fitria RahmitasariAfiliasi tidak diketahui1
Elly MunadzirohAfiliasi tidak diketahui1
Wahyu Aji WibowoAfiliasi tidak diketahui1
Retno Indrawati RoestamadjiAfiliasi tidak diketahui1
Puspa Dila RohmaniarAfiliasi tidak diketahui1
Maretaningtias Dwi ArianiAfiliasi tidak diketahui1
Saka WiniasAfiliasi tidak diketahui1
Rima Parwati SariAfiliasi tidak diketahui1
Syamsulina ReviantiAfiliasi tidak diketahui1
Widyasri PrananingrumAfiliasi tidak diketahui1
Sri Agus SudjarwoAfiliasi tidak diketahui1
Hansen KurniawanAfiliasi tidak diketahui1
Aisah Faiz BachmidAfiliasi tidak diketahui1
Amiyatun NainiAfiliasi tidak diketahui1
Mohammad RubiantoAfiliasi tidak diketahui1
Faurier Dzar Eljabbar LatiefAfiliasi tidak diketahui1
Louisa Christy LunardhiAfiliasi tidak diketahui1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Potency of Garcinia mangostana L peel extract combined with demineralized freeze-dried bovine bone xenograft on IL-1β expression, osteoblasts, and osteoclasts in alveolar bone</dc:title>
	<dc:creator>Azhar, Imam Safari</dc:creator>
	<dc:creator>Kresnoadi, Utari</dc:creator>
	<dc:creator>Rahayu, Retno Pudji</dc:creator>
	<dc:subject xml:lang="en-US">Alveolar bone</dc:subject>
	<dc:subject xml:lang="en-US">DFDBBX</dc:subject>
	<dc:subject xml:lang="en-US">Mangosteen peel extract</dc:subject>
	<dc:subject xml:lang="en-US">IL-1β expression</dc:subject>
	<dc:subject xml:lang="en-US">osteoblasts</dc:subject>
	<dc:subject xml:lang="en-US">osteoclasts</dc:subject>
	<dc:description xml:lang="en-US">Background: Alveolar bone plays an important role in supporting dentures. One socket preservation procedure is the application of bone graft to the tooth socket immediately after extraction. The administration of Garcinia mangostana L peel extract combined with demineralized freeze-dried bovine bone xenograft (DFDBBX) is assumed to decrease the number of osteoclast cells and IL-1β expressions, while also increasing that of osteoblast cells. Purpose: This study aimed to establish the potency of Garcinia mangostana L peel extract combined with DFDBBX on interleukin 1β expressions, osteoclast cells, and osteoblast cells during the preservation of tooth extraction sockets. Methods: This research constituted experimental laboratory-based research using 56 Cavia cobayas as specimens with randomized factorial design (true experimental design). These subjects were divided into eight groups, given PEG, DFDBBX, mangosteen peel extract or a combination of mangosteen peel extract and DFDBBX, and subsequently anesthesized before their left mandibular incisors were extracted. Thereafter, the post-extraction sockets were treated with PEG, DFDBBX, mangosteen peel extract or a combination of mangosteen peel extract and DFDBBX. The sockets were examined by means of HE and immunohistochemical staining on days 7 and 30 after extraction. The data obtained was analyzed with a one-way ANOVA test. Results: The results of the one-way ANOVA test showed that the average number of osteoblasts, osteoclasts, and IL-1β expressions varied significantly between the groups. Conclusion: The combination of mangosteen peel extract and DFDBBX can potentially increase osteoblasts, while also decreasing osteoclasts and IL-1β expressions in the alveolar bones of Cavia cobaya.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2017-09-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/6707</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v50.i3.p166-170</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 50 No. 3 (2017): September 2017; 166-170</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/6707/4570</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
</oai_dc:dc>