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Analysis of the relationship between human cytomegalovirus DNA and gB-1 genotype in the saliva of HIV/AIDS patients with xerostomia and salivary flow rate

Dental Journal (Majalah Kedokteran Gigi) · Vol. 52 No. 4 (2019) · hlm. 197–203

DOI
10.20473/j.djmkg.v52.i4.p197-203
ISSN
2442-9740, 1978-3728
Terbit
2019-12-31
Penerbit
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Bahasa
eng

Abstrak

Background: Human immunodeficiency virus (HIV) infection increases vulnerability to opportunistic viral infection, including Human cytomegalovirus (HCMV) infection, that has been detected in saliva. The HCMV envelope glycoprotein B (gB) is highly immunogenic and has been associated with HCMV-related diseases. Purpose: The purpose of this study is to assess the prevalence of HCMV and gB-1 genotype in the saliva of HIV/AIDS patients and to analyse their relationship with xerostomia and salivary flow rate (SFR). Methods: This cross-sectional study involved 34 HIV/AIDS patients. Saliva was tested for the presence of HCMV DNA using PCR microarrays, and nested PCR for gB-1 genotype detection. Xerostomia was measured using a Fox's questionnaire. Unstimulated whole saliva flow rate was measured by means of the spitting method. Results: The composition of the research population consisting of 73.5% males and 26.5% females with HIV/AIDS. HCMV was found in 64.7% of HIV/AIDS patients, while gB-1 genotype was detected in 59.1%. Xerostomia was closely associated with the presence of HCMV in saliva (p 0.05). Conclusion: The presence of xerostomia-associated HCMV in saliva was elevated among HIV/AIDS patients. Further investigation is required to identify other gB genotypes that may be responsible for xerostomia and SFR changes in HIV/AIDS patients.

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  • Padjadjaran University
  • Maranatha Christian University
  • Dr. Hasan Sadikin General Hospital
  • Udayana University
  • Kementerian Kesehatan Republik Indonesia
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Rekan penulisOrganisasiArtikel bersama
Sunardhi WidyaputraPadjadjaran University2
Tony S. DjajakusumahPadjadjaran University1
Asri Arum SariPadjadjaran University1
Budi SetiabudiawanPadjadjaran University1
Rahmat GunadiPadjadjaran University1
Riani SetiadhiPadjadjaran University1
Eliza Kristina MunthePadjadjaran University1
Dewi Marhaeni Diah HerawatiPadjadjaran University1
Ignatius SetiawanMaranatha Christian University1
Ananda SagitaMaranatha Christian University1
Ibnu SuryatmojoMaranatha Christian University1
Vatchala Rani RamamoorthyAfiliasi tidak diketahui1
Alamsyah PiliangPadjadjaran University1
Tenny Setiani DewiPadjadjaran University1
Imme Kris WicaksonoPadjadjaran University1
M. Hasan HapidPadjadjaran University1
Adji KusumadjatiDr. Hasan Sadikin General Hospital1
Nanan Nur’aenyPadjadjaran University1
Dida Akhmad GurnidaDr. Hasan Sadikin General Hospital1
Oki SuwarsaDr. Hasan Sadikin General Hospital1
Pande Putu JanuragaUdayana University1
Adiatma SiregarAfiliasi tidak diketahui1
Mery Nurma JuwitaPadjadjaran University1
Donny HardiawanPadjadjaran University1
Rozar PrawinegaraPadjadjaran University1
Miasari HandayaniPadjadjaran University1
Nurjannah SulaimanKementerian Kesehatan Republik Indonesia1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Analysis of the relationship between human cytomegalovirus DNA and gB-1 genotype in the saliva of HIV/AIDS patients with xerostomia and salivary flow rate</dc:title>
	<dc:creator>Sufiawati, Irna</dc:creator>
	<dc:creator>Suniti, S.</dc:creator>
	<dc:creator>Nelonda, Revi</dc:creator>
	<dc:creator>Wisaksana, Rudi</dc:creator>
	<dc:creator>Rendati, Agnes Rengga</dc:creator>
	<dc:creator>Amalia, Riezki</dc:creator>
	<dc:creator>Tampubolon, Isabellina Dwades</dc:creator>
	<dc:subject xml:lang="en-US">glycoproteins B-1</dc:subject>
	<dc:subject xml:lang="en-US">human cytomegalovirus</dc:subject>
	<dc:subject xml:lang="en-US">human immunodeficiency virus</dc:subject>
	<dc:subject xml:lang="en-US">xerostomia</dc:subject>
	<dc:description xml:lang="en-US">Background: Human immunodeficiency virus (HIV) infection increases vulnerability to opportunistic viral infection, including Human cytomegalovirus (HCMV) infection, that has been detected in saliva. The HCMV envelope glycoprotein B (gB) is highly immunogenic and has been associated with HCMV-related diseases. Purpose: The purpose of this study is to assess the prevalence of HCMV and gB-1 genotype in the saliva of HIV/AIDS patients and to analyse their relationship with xerostomia and salivary flow rate (SFR). Methods: This cross-sectional study involved 34 HIV/AIDS patients. Saliva was tested for the presence of HCMV DNA using PCR microarrays, and nested PCR for gB-1 genotype detection. Xerostomia was measured using a Fox's questionnaire. Unstimulated whole saliva flow rate was measured by means of the spitting method. Results: The composition of the research population consisting of 73.5% males and 26.5% females with HIV/AIDS. HCMV was found in 64.7% of HIV/AIDS patients, while gB-1 genotype was detected in 59.1%. Xerostomia was closely associated with the presence of HCMV in saliva (p&amp;lt;0.05), but not with gB-1. There was no significant relationship between xerostomia and SFR rates in the research subjects with HCMV positive saliva (p&amp;gt; 0.05). Conclusion: The presence of xerostomia-associated HCMV in saliva was elevated among HIV/AIDS patients. Further investigation is required to identify other gB genotypes that may be responsible for xerostomia and SFR changes in HIV/AIDS patients.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2019-12-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/17012</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v52.i4.p197-203</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 52 No. 4 (2019): December 2019; 197-203</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/17012/9665</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2019 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
</oai_dc:dc>