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The effect of propolis extract and bovine bone graft combination on the number of osteoclast and osteoblast as an effort to preserve post-extraction socket (on Cavia cobaya)

Dental Journal (Majalah Kedokteran Gigi) · Vol. 53 No. 1 (2020) · hlm. 10–15

DOI
10.20473/j.djmkg.v53.i1.p10-15
ISSN
2442-9740, 1978-3728
Terbit
2020-03-31
Penerbit
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Bahasa
eng

Abstrak

Background: Post-extraction alveolar bone height and width never reach the same dimensions as before extraction. A combination of propolis extracts and bovine bone graft (BBG) that are anti-inflammatory, antioxidant, osteoinductive and osteconductive is expected to improve bone regeneration. Purpose: Knowing the effect of the combination of propolis extracts and BBG on the number of osteoclast and osteoblast as an effort to preserve the socket after extraction of Cavia cobaya teeth. Methods: 56 Cavia cobaya was divided into eight groups: the lower left incisor was extracted, and the socket was filled with 2% poly ethylene glycol (PEG), propolis extract+PEG, BBG+PEG, and a combination of propolis extract+BBG+PEG. The incisors socket of animals models were executed on the 14th and 30th days. Using HE for histopathological examination, the number of osteoclasts and osteoblasts were counted with a 400x magnification light microscope with nine visual fields. The data were analysed via one-way ANOVA and Tukey HSD tests. Results: The highest mean number of osteoclasts occurred in the BBG+PEG 14th day group and the lowest occurred in the propolis extract+BBG+PEG 14th day group. The highest mean number of osteoblasts occurred in the propolis + BBG + PEG combination 30th day group, the lowest occurred in the control group (PEG) on the 14th day. Conclusion: The 2% combination of propolis extracts and BBG effectively reduces the osteoclast number and increases the osteoblast number in preserving the socket after extracting Cavia cobaya teeth.

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34 penulis · 79 tautan kepenulisan bersama · 20 lintas organisasi

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  • Universitas Airlangga
  • Bhatia Hospital
  • Universitas Jember
  • Bandung Institute of Technology
  • Tohoku University
  • Universitas Ciputra
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Rekan penulisOrganisasiArtikel bersama
Retno Pudji RahayuUniversitas Airlangga3
Imam Safari AzharUniversitas Airlangga2
Hanoem Eka HidayatiUniversitas Airlangga2
Eha DjulaehaUniversitas Airlangga1
Arif RachmanAfiliasi tidak diketahui1
Rostiny RostinyUniversitas Airlangga1
Waloejo NoegrohoBhatia Hospital1
Adi SubiantoUniversitas Airlangga1
Yurike HadisoesantoUniversitas Airlangga1
Harly PrabowoUniversitas Airlangga1
Agus DahlanUniversitas Airlangga1
Adrian AlfiandyUniversitas Airlangga1
Sherman SalimUniversitas Airlangga1
Karina MundiratriUniversitas Airlangga1
Faurier Dzar Eljabbar LatiefBandung Institute of Technology1
I Ketut SudianaUniversitas Airlangga1
Amiyatun NainiUniversitas Jember1
Mohammad RubiantoUniversitas Airlangga1
Louisa Christy LunardhiUniversitas Airlangga1
Bambang AgustonoUniversitas Airlangga1
Teguh Setio Yuli PrabowoUniversitas Airlangga1
Birgitta Dwitya Swastyayana SubiaktoUniversitas Airlangga1
Najla SalsabilaUniversitas Airlangga1
Primanda Nur RahmaniaUniversitas Airlangga1
Phara Aster Chandra AdventiaUniversitas Airlangga1
Bima Subiakto RahmaniUniversitas Airlangga1
Nobuhiro YodaTohoku University1
Ratri Maya SitalaksmiUniversitas Airlangga1
Cindy Ramadhan PutriUniversitas Airlangga1
Aishley YutassaUniversitas Airlangga1
Jennifer WidjajaUniversitas Ciputra1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The effect of propolis extract and bovine bone graft combination on the number of osteoclast and osteoblast as an effort to preserve post-extraction socket (on Cavia cobaya)</dc:title>
	<dc:creator>Nizar, Much</dc:creator>
	<dc:creator>Kresnoadi, Utari</dc:creator>
	<dc:creator>Soekobagiono, S.</dc:creator>
	<dc:subject xml:lang="en-US">bovine bone graft</dc:subject>
	<dc:subject xml:lang="en-US">osteoblast</dc:subject>
	<dc:subject xml:lang="en-US">osteoclast</dc:subject>
	<dc:subject xml:lang="en-US">propolis extract</dc:subject>
	<dc:subject xml:lang="en-US">socket preservation</dc:subject>
	<dc:description xml:lang="en-US">Background: Post-extraction alveolar bone height and width never reach the same dimensions as before extraction. A combination of propolis extracts and bovine bone graft (BBG) that are anti-inflammatory, antioxidant, osteoinductive and osteconductive is expected to improve bone regeneration. Purpose: Knowing the effect of the combination of propolis extracts and BBG on the number of osteoclast and osteoblast as an effort to preserve the socket after extraction of Cavia cobaya teeth. Methods: 56 Cavia cobaya was divided into eight groups: the lower left incisor was extracted, and the socket was filled with 2% poly ethylene glycol (PEG), propolis extract+PEG, BBG+PEG, and a combination of propolis extract+BBG+PEG. The incisors socket of animals models were executed on the 14th and 30th days. Using HE for histopathological examination, the number of osteoclasts and osteoblasts were counted with a 400x magnification light microscope with nine visual fields. The data were analysed via one-way ANOVA and Tukey HSD tests. Results: The highest mean number of osteoclasts occurred in the BBG+PEG 14th day group and the lowest occurred in the propolis extract+BBG+PEG 14th day group. The highest mean number of osteoblasts occurred in the propolis + BBG + PEG combination 30th day group, the lowest occurred in the control group (PEG) on the 14th day. Conclusion: The 2% combination of propolis extracts and BBG effectively reduces the osteoclast number and increases the osteoblast number in preserving the socket after extracting Cavia cobaya teeth.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2020-03-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/17746</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v53.i1.p10-15</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 53 No. 1 (2020): March 2020; 10-15</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/17746/9901</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
</oai_dc:dc>