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Lemuru fish oil gel as host modulation therapy in periodontal ligaments induced with Porphyromonas gingivalis

Dental Journal (Majalah Kedokteran Gigi) · Vol. 53 No. 4 (2020) · hlm. 229–234

DOI
10.20473/j.djmkg.v53.i4.p229-234
ISSN
2442-9740, 1978-3728
Terbit
2020-12-15
Penerbit
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Bahasa
eng

Abstrak

Background: Periodontitis affects approximately 20%–50% of the global population and is caused by gram-negative bacteria, such as Porphyromonas gingivalis (P. gingivalis). Host modulation therapy (HMT) is part of a periodontal therapy that is used as an adjunct to conventional periodontal treatment to reduce tissue damage. Lemuru fish oil containing EPA and DHA can reduce the formation of MMPs and will further increase the number of fibroblasts there by stimulating collagen formation. Purpose: To determine the effect of lemuru fish oil gel on the collagen density and width of the periodontal tissue induced by P. gingivalis and the correlation between these parameters. Methods: Thirty male Wistar rats were divided into five groups. Induction of P. gingivalis was carried out first, then lemuru fish oil gel was applied to the gingival sulcus for 14 days, according to collagen scores in histological preparations using Masson's trichrome (MT). The width of the periodontal ligament was measured with an image raster program in µm. The data were analysed using statistics to test hypotheses using SPSS version 24. Results: Significant differences in the results of the collagen density were observed between groups K- and K+ and groups K+ and P2. Meanwhile, no significant difference was observed between groups K- and P2, P3, P2 and P3 and K+ and P1. The mean values of the periodontal ligament widths were K- (299.61 ± 51.82µm), K+ (425.85 ± 61.54µm), P1 (346.93 ± 33.53µm), P2 (370.15 ± 49.42µm) and P3 (379.6 ± 49.26). Conclusion: Lemuru fish oil can affect the width of the ligament and the collagen density with an optimal concentration of 20%. The correlation between the collagen density and the periodontal ligament width was negative and not significant.

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  • Universitas Airlangga
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Rekan penulisOrganisasiArtikel bersama
Kristanti ParisihniAfiliasi tidak diketahui2
Dwi AndrianiAfiliasi tidak diketahui2
Farizia Putri KhoirunnisaAfiliasi tidak diketahui2
Alifati Nita JuliatinAfiliasi tidak diketahui2
A.H. GunawanAfiliasi tidak diketahui1
Widyastuti WidyastutiAfiliasi tidak diketahui1
Ramadhan Hardani PutraUniversitas Airlangga1
Dwi SetianingtyasAfiliasi tidak diketahui1
Paulus Budi TeguhAfiliasi tidak diketahui1
Neken PrasetyaningtyasAfiliasi tidak diketahui1
Felicia Eda HaryantoAfiliasi tidak diketahui1
Rima Parwati SariAfiliasi tidak diketahui1
Hansen KurniawanAfiliasi tidak diketahui1
Mery Esterlita HutapeaAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Lemuru fish oil gel as host modulation therapy in periodontal ligaments induced with Porphyromonas gingivalis</dc:title>
	<dc:creator>Widyastuti, W.</dc:creator>
	<dc:creator>Damaiyanti, Dian Widya</dc:creator>
	<dc:creator>Mulawarmanti, Dian</dc:creator>
	<dc:creator>Sari, Cindy Aprilia</dc:creator>
	<dc:creator>Siwi, Diah Ayu</dc:creator>
	<dc:subject xml:lang="en-US">Collagen density</dc:subject>
	<dc:subject xml:lang="en-US">lemuru fish oil</dc:subject>
	<dc:subject xml:lang="en-US">periodontitis width of the periodontal ligament</dc:subject>
	<dc:description xml:lang="en-US">Background: Periodontitis affects approximately 20%–50% of the global population and is caused by gram-negative bacteria, such as Porphyromonas gingivalis (P. gingivalis). Host modulation therapy (HMT) is part of a periodontal therapy that is used as an adjunct to conventional periodontal treatment to reduce tissue damage. Lemuru fish oil containing EPA and DHA can reduce the formation of MMPs and will further increase the number of fibroblasts there by stimulating collagen formation. Purpose: To determine the effect of lemuru fish oil gel on the collagen density and width of the periodontal tissue induced by P. gingivalis and the correlation between these parameters. Methods: Thirty male Wistar rats were divided into five groups. Induction of P. gingivalis was carried out first, then lemuru fish oil gel was applied to the gingival sulcus for 14 days, according to collagen scores in histological preparations using Masson's trichrome (MT). The width of the periodontal ligament was measured with an image raster program in µm. The data were analysed using statistics to test hypotheses using SPSS version 24. Results: Significant differences in the results of the collagen density were observed between groups K- and K+ and groups K+ and P2. Meanwhile, no significant difference was observed between groups K- and P2, P3, P2 and P3 and K+ and P1. The mean values of the periodontal ligament widths were K- (299.61 ± 51.82µm), K+ (425.85 ± 61.54µm), P1 (346.93 ± 33.53µm), P2 (370.15 ± 49.42µm) and P3 (379.6 ± 49.26). Conclusion: Lemuru fish oil can affect the width of the ligament and the collagen density with an optimal concentration of 20%. The correlation between the collagen density and the periodontal ligament width was negative and not significant.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2020-12-15</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/21547</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v53.i4.p229-234</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 53 No. 4 (2020): December 2020; 229-234</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/21547/13079</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Dental Journal (Majalah Kedokteran Gigi)</dc:rights>
</oai_dc:dc>