Confirmation of the potential mechanism of pentagamavunon-0 against temporomandibular arthritis using bioinformatic approaches

Robin, Dwi Merry Christmarini; Ardhani, Retno; Novitasari, Dhania; Kusumawardani, Banun; Aulia Rahman, Faaza; Meiyanto, Edy; Purwanti, Nunuk

doi:10.20473/j.djmkg.v58.i4.p367-375

Akses terbuka Jurnal SINTA 1

Confirmation of the potential mechanism of pentagamavunon-0 against temporomandibular arthritis using bioinformatic approaches

Dental Journal (Majalah Kedokteran Gigi) · Vol. 58 No. 4 (2025) · hlm. 367–375

DOI: 10.20473/j.djmkg.v58.i4.p367-375
ISSN: 2442-9740, 1978-3728
Terbit: 2025-09-10
Penerbit: Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Bahasa: eng
Lisensi: creativecommons.org/licenses/by-sa/4.0

Abstrak

Background: Non-steroidal anti-inflammatory drugs (NSAID) are widely used in temporomandibular joint osteoarthritis management. However, the side effects of NSAIDs on multiple organs need to be anticipated. Curcumin is known for its anti-inflammatory and analgesic potential, comparable to that of NSAIDs. In a previous study, structurally modified curcumin increased the pharmacological effect and simultaneously reduced the toxicity and side effects of curcumin. Pentagamavunon-0 (PGV-0) is one of the active components synthesized by the structure modification of curcumin. Purpose: In this study, we identify the potential target of PGV-0 on the pathogenesis of temporomandibular arthritis characterized by inflammation. Methods: We used a bioinformatics approach to compare the PGV-0 target with curcumin and diclofenac sodium as controls. We identified overlapping gene targets of bioactive compounds (PGV-0, curcumin, or diclofenac sodium) retrieved from the SwissTargetPrediction and GeneCards platforms, specifically for temporomandibular arthritis. An interaction model among targets was developed using the STRING database and Gene Ontology Panther to expound on the bioactive compound’s function on the key signaling pathway. Finally, we formulated a molecular docking prediction between the bioactive compound and the target protein marker derived from the previous analysis using Molecular Operating Environment tools. Results: This study found that curcumin and PGV-0 targeted different molecular pathways in temporomandibular arthritis compared to diclofenac sodium. Curcumin and PGV-0 shared a similar pathway to curcumin by modulating metalloproteinases (MMPs), especially MMP-9 and MMP-13. Moreover, diclofenac sodium influenced cyclooxygenase metabolism. Conclusion: In this study, PGV-0 targeted metalloproteinase in temporomandibular arthritis pathogenesis. This finding underlines the PGV-0 advantage in preventing metalloproteinase-related tissue damage in temporomandibular arthritis.

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Rekan penulis	Organisasi	Artikel bersama
Adam Hermawan	Afiliasi tidak diketahui	18
Ratna Asmah Susidarti	Afiliasi tidak diketahui	17
Riris Istighfari Jenie	Afiliasi tidak diketahui	16
Muthi’ Ikawati	Afiliasi tidak diketahui	11
Rohmad Yudi Utomo	Afiliasi tidak diketahui	8
Dyaningtyas Dewi Pamungkas Putri	Afiliasi tidak diketahui	7
Sari Haryanti	Afiliasi tidak diketahui	6
Retno Murwanti	Afiliasi tidak diketahui	5
Faaza Aulia Rahman	Afiliasi tidak diketahui	4
Desty Restia Rahmawati	Afiliasi tidak diketahui	4
Sri Handayani	University of Brawijaya	4
Ummi Maryam Zulfin	Afiliasi tidak diketahui	3
Anindyajati Anindyajati	Afiliasi tidak diketahui	3
Larasati Larasati	IPB University	3
Erlina Rivanti	Afiliasi tidak diketahui	3
Endah Puspitasari	Afiliasi tidak diketahui	3
Beni Lestari	Afiliasi tidak diketahui	3
Fajar Oktavian Muljono	Afiliasi tidak diketahui	2
Firghi Muhammad Fardhan	Afiliasi tidak diketahui	2
Masashi Kawaichi	Afiliasi tidak diketahui	2
Sendy Junedi	Afiliasi tidak diketahui	2
Nunuk Aries Nurulita	Afiliasi tidak diketahui	2
Suwijiyo Pramono	Afiliasi tidak diketahui	2
Zalinar Udin	Afiliasi tidak diketahui	2
Yogi Ertanto	Afiliasi tidak diketahui	2
Lailatul Qodria	Afiliasi tidak diketahui	2
Gergorius Gena Maran	Afiliasi tidak diketahui	2
Aulia Nur Septiani	Afiliasi tidak diketahui	2
Sofa Farida	Afiliasi tidak diketahui	2
Asri Mega Putri	Afiliasi tidak diketahui	2
Hilyatul Fadliyah	Afiliasi tidak diketahui	2
Indri Kusharyanti	Afiliasi tidak diketahui	2
Djaswadi Dasuki	Afiliasi tidak diketahui	2

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.

Metadata asli (oai_dc)

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	<dc:title xml:lang="en-US">Confirmation of the potential mechanism of pentagamavunon-0 against temporomandibular arthritis using bioinformatic approaches</dc:title>
	<dc:creator>Robin, Dwi Merry Christmarini</dc:creator>
	<dc:creator>Ardhani, Retno</dc:creator>
	<dc:creator>Novitasari, Dhania</dc:creator>
	<dc:creator>Kusumawardani, Banun</dc:creator>
	<dc:creator>Aulia Rahman, Faaza</dc:creator>
	<dc:creator>Meiyanto, Edy</dc:creator>
	<dc:creator>Purwanti, Nunuk</dc:creator>
	<dc:subject xml:lang="en-US">anti-inflammatory agent</dc:subject>
	<dc:subject xml:lang="en-US">cyclooxygenase</dc:subject>
	<dc:subject xml:lang="en-US">curcumin</dc:subject>
	<dc:subject xml:lang="en-US">diclofenac sodium</dc:subject>
	<dc:subject xml:lang="en-US">chronic inflammation</dc:subject>
	<dc:subject xml:lang="en-US">metalloproteinase</dc:subject>
	<dc:description xml:lang="en-US">Background: Non-steroidal anti-inflammatory drugs (NSAID) are widely used in temporomandibular joint osteoarthritis management. However, the side effects of NSAIDs on multiple organs need to be anticipated. Curcumin is known for its anti-inflammatory and analgesic potential, comparable to that of NSAIDs. In a previous study, structurally modified curcumin increased the pharmacological effect and simultaneously reduced the toxicity and side effects of curcumin. Pentagamavunon-0 (PGV-0) is one of the active components synthesized by the structure modification of curcumin. Purpose: In this study, we identify the potential target of PGV-0 on the pathogenesis of temporomandibular arthritis characterized by inflammation. Methods: We used a bioinformatics approach to compare the PGV-0 target with curcumin and diclofenac sodium as controls. We identified overlapping gene targets of bioactive compounds (PGV-0, curcumin, or diclofenac sodium) retrieved from the SwissTargetPrediction and GeneCards platforms, specifically for temporomandibular arthritis. An interaction model among targets was developed using the STRING database and Gene Ontology Panther to expound on the bioactive compound’s function on the key signaling pathway. Finally, we formulated a molecular docking prediction between the bioactive compound and the target protein marker derived from the previous analysis using Molecular Operating Environment tools. Results: This study found that curcumin and PGV-0 targeted different molecular pathways in temporomandibular arthritis compared to diclofenac sodium. Curcumin and PGV-0 shared a similar pathway to curcumin by modulating metalloproteinases (MMPs), especially MMP-9 and MMP-13. Moreover, diclofenac sodium influenced cyclooxygenase metabolism. Conclusion: In this study, PGV-0 targeted metalloproteinase in temporomandibular arthritis pathogenesis. This finding underlines the PGV-0 advantage in preventing metalloproteinase-related tissue damage in temporomandibular arthritis.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2025-09-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:format>text/xml</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/56898</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v58.i4.p367-375</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 58 No. 4 (2025): December; 367-375</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/56898/33981</dc:relation>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/56898/35018</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Dental Journal</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
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