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Alpha-Glucosidase Inhibition and Hypoglycemic Activities of Sweitenia mahagoni Seed Extract

HAYATI Journal of Biosciences · Vol. 22 No. 2 (2015)

DOI
10.4308/hjb.22.2.73
ISSN
2086-4094, 1978-3019
Terbit
2015-10-08
Penerbit
Bogor Agricultural University, Indonesia
Bahasa
eng

Abstrak

Inhibition of α-glucosidase and hypoglycemic activity are two effects commonly used to identify bioactive compounds with potential to treat diabetes. The objectives of this study were to analyse and compare the bioactive compounds and α-glucosidase inhibitory effect of four different types of Swietenia mahagoni seed extract, and to analyse the hypoglycemic activity of the greatest inhibition of α-glucosidase-extract in rats. The extracts were obtained using two different solvents (aqueous and ethanol) and two different methods: maceration and reflux methods. This resulted in four types of extract varying by solvent and extraction method. Testing of these extracts for α-glucosidase inhibitory effect was carried out in vitro using spectrophotometer. Testing for hypoglycemic activity was carried out in vivo using rats. A total of 40 male Sprague-Dawley rats were divided into eight groups: (1) the negative control group, received an oral dose of aquadest only, (2) the positive control group, was given 90% sucrose orally without S. mahagoni seed extract, and five treated groups (3-7), were given 90% sucrose followed by the best extract-ethanolic S. mahagoni seed extract in doses of 100, 200, 300, 400, and 500 mg/kgBW, and (8) the acarbose group, was given 90% sucrose orally followed by acarbose. Glucose levels in each animal were measured at 0, 30, 60, 90, and 120 min after treatment. The results showed the greatest inhibition of α-glucosidase in ethanolic extract, using maceration methods. This ethanolic-maceration S. mahagoni seed extract also showed hypoglycemic effects in hyperglycemic rats at dose from 100 to 500 mg/kgBW. Ethanolic extract of S. mahagoni seed, using maceration method, can be proposed as potential antidiabetic agent.

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  • IPB University
  • National Research and Innovation Agency
  • The University of Osaka
  • Binus University
  • Indonesian Agency for Agricultural Research and Development
  • Udayana University
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Rekan penulisOrganisasiArtikel bersama
Made AstawanIPB University6
Wasmen ManaluIPB University3
Ekowati HandharyaniIPB University2
Deddy MuchtadiIPB University2
Arief BoedionoIPB University2
Krido Brahmo PutroIPB University2
Bambang PurwantaraIPB University2
Saraswati SaraswatiIPB University1
Ayu Putri Gitanjali PrayudaniIPB University1
Nabila Az Zahra YalmaidaIPB University1
Aprilia Firdha DamayantiAfiliasi tidak diketahui1
Ans Budi HartantaIPB University1
Teguh Suranta SinulinggaIPB University1
Yoli ZulfanediIPB University1
Sastia Prama PutriThe University of Osaka1
Eiichiro FukusakiThe University of Osaka1
Inas Suci RahmawatiIPB University1
Ananda Putri CahyaniIPB University1
Alamsah FirdausIPB University1
Irma Herawati SupartoIPB University1
Huda Shalahudin DarusmanIPB University1
Sela Septima MariyaIPB University1
Uus SaepulohIPB University1
Lis RosmanahIPB University1
Eko Setyo PurwantoBinus University1
Umi CahyaningsihIPB University1
Didik Tulus SubektiNational Research and Innovation Agency1
Fitrine EkawastiNational Research and Innovation Agency1
Farlin NephoNational Research and Innovation Agency1
Dyah Ayu KurniawatiIndonesian Agency for Agricultural Research and Development1
Rini DamayantiNational Research and Innovation Agency1
Maria BintangIPB University1
Bambang Pontjo PriosoeryantoIPB University1
I Nyoman SuarsanaUdayana University1
Agik SuprayogiIPB University1
Suarsana INAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/hayati/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Alpha-Glucosidase Inhibition and Hypoglycemic Activities of Sweitenia mahagoni Seed Extract</dc:title>
	<dc:creator xml:lang="en">WRESDIYATI, TUTIK</dc:creator>
	<dc:creator xml:lang="en">SA’DIAH, SITI</dc:creator>
	<dc:creator xml:lang="en">WINARTO, ADI</dc:creator>
	<dc:creator xml:lang="en">FEBRIYANI, VENNY</dc:creator>
	<dc:subject xml:lang="en">Swietenia mahagoni</dc:subject>
	<dc:subject xml:lang="en">α-glucosidase</dc:subject>
	<dc:subject xml:lang="en">hypoglycemia</dc:subject>
	<dc:subject xml:lang="en">ethanolic extract</dc:subject>
	<dc:subject xml:lang="en">antidiabetic</dc:subject>
	<dc:description xml:lang="en">Inhibition of α-glucosidase and hypoglycemic activity are two effects commonly used to identify bioactive compounds with potential to treat diabetes. The objectives of this study were to analyse and compare the bioactive compounds and α-glucosidase inhibitory effect of four different types of Swietenia mahagoni seed extract, and to analyse the hypoglycemic activity of the greatest inhibition of α-glucosidase-extract in rats. The extracts were obtained using two different solvents (aqueous and ethanol) and two different methods: maceration and reflux methods. This resulted in four types of extract varying by solvent and extraction method.  Testing of these extracts for α-glucosidase inhibitory effect was carried out in vitro using spectrophotometer. Testing for hypoglycemic activity was carried out in vivo using rats. A total of 40 male Sprague-Dawley rats were divided into eight groups: (1) the negative control group, received an oral dose of aquadest only, (2) the positive control group, was given 90% sucrose orally without S. mahagoni seed extract, and five treated groups (3-7), were given 90% sucrose followed by the best extract-ethanolic S. mahagoni seed extract in doses of 100, 200, 300, 400, and 500 mg/kgBW, and (8) the acarbose group, was given 90% sucrose orally followed by acarbose. Glucose levels in each animal were measured at 0, 30, 60, 90, and 120 min after treatment. The results showed the greatest inhibition of α-glucosidase in ethanolic extract, using maceration methods. This ethanolic-maceration S. mahagoni seed extract also showed hypoglycemic effects in hyperglycemic rats at dose from 100 to 500 mg/kgBW. Ethanolic extract of S. mahagoni seed, using maceration method, can be proposed as potential antidiabetic agent.</dc:description>
	<dc:publisher xml:lang="en">Bogor Agricultural University, Indonesia</dc:publisher>
	<dc:date>2015-10-08</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://journal.ipb.ac.id/hayati/article/view/10263</dc:identifier>
	<dc:identifier>10.4308/hjb.22.2.73</dc:identifier>
	<dc:source xml:lang="en">HAYATI Journal of Biosciences; Vol. 22 No. 2 (2015): April 2015; 73</dc:source>
	<dc:source>2086-4094</dc:source>
	<dc:source>1978-3019</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://journal.ipb.ac.id/hayati/article/view/10263/7973</dc:relation>
</oai_dc:dc>