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Lack of Radioprotective Potential of Ginseng in Suppressing Micronuclei Frequency in Human Blood Lymphocyte under Gamma Irradiation

HAYATI Journal of Biosciences · Vol. 22 No. 2 (2015)

DOI
10.4308/hjb.22.2.93
ISSN
2086-4094, 1978-3019
Terbit
2015-04-01
Penerbit
Bogor Agricultural University, Indonesia
Bahasa
eng

Abstrak

Ginseng appears to be a promising radioprotector for therapeutic or preventive protocols capable of attenuating the deleterious effects of radiation on human normal tissue. This research addresses results on the study of radioprotective potential of ginseng on radiation induced micronuclei in lymphocyte cells in vitro. The peripheral blood samples were exposed to gamma rays at doses of 0.0, 0.5, and 1.0 Gy and then added with 0, 100, and 1000 ug/mL of ginseng extract. These treated samples were cultured for micronuclei (MN) examination using standard procedure. The evaluation of incubation with ginseng extract for 24 h before irradiation was also done. Our results showed that there was no radioprotective effect of ginseng addition to the frequency of MN in lymphocyte cells. Pre-incubation with ginseng extract before irradiation also did not effectively suppress the MN frequency. This research lacks to prove the ginseng’s radioprotective potential that maybe related to its immunomodulating capabilities and its capabilities in scavenging free radicals induced by radiation or in attenuating the deleterious effects of radiation and its important role in increasing levels of several cytokines.

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  • National Nuclear Energy Agency of Indonesia
  • Korea Institute of Radiological and Medical Sciences
  • Dr. Hasan Sadikin General Hospital
  • Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
  • State University of Semarang
  • National Research and Innovation Agency
  • Dharmais Cancer Hospital
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  • Organisasi berbeda
  • Organisasi sama
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Rekan penulisOrganisasiArtikel bersama
Sofiati PurnamiNational Nuclear Energy Agency of Indonesia9
Devita TetrianaNational Nuclear Energy Agency of Indonesia9
Dwi RamadhaniNational Nuclear Energy Agency of Indonesia9
Siti NurhayatiNational Nuclear Energy Agency of Indonesia7
Tur RahardjoNational Nuclear Energy Agency of Indonesia6
Teja KisnantoNational Nuclear Energy Agency of Indonesia5
Darlina DarlinaNational Nuclear Energy Agency of Indonesia4
Harry Nugroho Eko SurniyantoroNational Nuclear Energy Agency of Indonesia4
Ikuo KashiwakuraHirosaki University3
Nastiti RahajengNational Nuclear Energy Agency of Indonesia3
Masnelli LubisNational Nuclear Energy Agency of Indonesia3
H. DateHokkaido University2
Bethy Suryawathy HernowoDr. Hasan Sadikin General Hospital2
Iin KurniaNational Nuclear Energy Agency of Indonesia2
Budiningsih SiregarRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo2
Irwan RamliRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo2
Tjahya KurjanaDr. Hasan Sadikin General Hospital2
A. AndrionoRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo2
Maringan Diapari Lumban TobingDr. Hasan Sadikin General Hospital2
Setiawan SoetopoDr. Hasan Sadikin General Hospital2
Yerin LeeEwha Womans University2
Chang‐Mo KangKorea Institute of Radiological and Medical Sciences2
Viria Agesti SuvifanNational Nuclear Energy Agency of Indonesia2
Jie Young SongKorea Institute of Radiological and Medical Sciences1
Yun Sil LeeKorea Institute of Radiological and Medical Sciences1
Chang Mo KangKorea Institute of Radiological and Medical Sciences1
I.K.H. BasriNational Nuclear Energy Agency of Indonesia1
Yustinus Ulung AnggraitoState University of Semarang1
Amalia Dyah PratiwiState University of Semarang1
Darlina YusufNational Nuclear Energy Agency of Indonesia1
M. R. A. GaniDharmais Cancer Hospital1
I.K. Hasan BasriNational Research and Innovation Agency1
Ayu Rosemeilia DewiDharmais Cancer Hospital1
V. A. SuvivanNational Research and Innovation Agency1
Wiwin MailanaNational Nuclear Energy Agency of Indonesia1
Eko PudjadiNational Nuclear Energy Agency of Indonesia1
K. D. PurwantiNational Nuclear Energy Agency of Indonesia1

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/hayati/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Lack of Radioprotective Potential of Ginseng in Suppressing Micronuclei Frequency in Human Blood Lymphocyte under Gamma Irradiation</dc:title>
	<dc:creator xml:lang="en">LUSIYANTI, YANTI</dc:creator>
	<dc:creator xml:lang="en">ALATAS, ZUBAIDAH</dc:creator>
	<dc:creator xml:lang="en">SYAIFUDIN, MUKH</dc:creator>
	<dc:subject xml:lang="en">gamma rays</dc:subject>
	<dc:subject xml:lang="en">ginseng</dc:subject>
	<dc:subject xml:lang="en">micronuclei</dc:subject>
	<dc:subject xml:lang="en">radioprotective effects</dc:subject>
	<dc:description xml:lang="en">Ginseng appears to be a promising radioprotector for therapeutic or preventive protocols capable of attenuating the deleterious effects of radiation on human normal tissue. This research addresses results on the study of radioprotective potential of ginseng on radiation induced micronuclei in lymphocyte cells in vitro. The peripheral blood samples were exposed to gamma rays at doses of 0.0, 0.5, and 1.0 Gy and then added with 0, 100, and 1000 ug/mL of ginseng extract. These treated samples were cultured for micronuclei (MN) examination using standard procedure. The evaluation of incubation with ginseng extract for 24 h before irradiation was also done. Our results showed that there was no radioprotective effect of ginseng addition to the frequency of MN in lymphocyte cells. Pre-incubation with ginseng extract before irradiation also did not effectively suppress the MN frequency. This research lacks to prove the ginseng’s radioprotective potential that maybe related to its immunomodulating capabilities and its capabilities in scavenging free radicals induced by radiation or in attenuating the deleterious effects of radiation and its important role in increasing levels of several cytokines.</dc:description>
	<dc:publisher xml:lang="en">Bogor Agricultural University, Indonesia</dc:publisher>
	<dc:date>2015-04-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://journal.ipb.ac.id/hayati/article/view/10267</dc:identifier>
	<dc:identifier>10.4308/hjb.22.2.93</dc:identifier>
	<dc:source xml:lang="en">HAYATI Journal of Biosciences; Vol. 22 No. 2 (2015): April 2015; 93</dc:source>
	<dc:source>2086-4094</dc:source>
	<dc:source>1978-3019</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://journal.ipb.ac.id/hayati/article/view/10267/7976</dc:relation>
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