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Expression of Hypoxia-Inducible Factor-1α and Myoglobin in Rat Heart as Adaptive Response to Intermittent Hypobaric Hypoxia Exposure

HAYATI Journal of Biosciences · Vol. 24 No. 3 (2018)

DOI
10.4308/hjb.24.3.131
ISSN
2086-4094, 1978-3019
Terbit
2018-03-26
Penerbit
Bogor Agricultural University, Indonesia
Bahasa
eng

Abstrak

The aim of this study was to investigate the influence of intermittent hypobaric hypoxia on the expression hypoxia adaptation proteins, namely hypoxia inducibla factor-1a (HIF-1a) and myoglobin (Mb). Twenty five male Sprague-Dawley rats were exposed to intermittent hypobaric hypoxia in a hypobaric chamber in Indonesian Air Force Institute of Aviation Medicine, for 49.5 minutes at various low pressure, 1 week interval for 4 times (day 1, 8, 15 and 22). HIF-1α and Mb protein were measured with ELISA. mRNA expression of Mb was measured with one step real time RT-PCR. HIF-1α protein levels increased after induction of hypobaric hypoxia and continues to decrease after induction of intermittent hypobaric hypoxia 3 times (ANOVA, p = 0.0437). mRNA expression and protein of Mb increased after induction of hypobaric hypoxia and continues to decrease after induction of intermittent hypobaric hypoxia 3 times (ANOVA, p = 0.0283; 0.0170), and both are strongly correlated (Pearson, r = 0.6307). The heart of rats adapted to intermittent hypoxia conditions by upregulation the expression of HIF-1a and myoglobin and then both return to normal level.

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  • University of Indonesia
  • Sriwijaya University
  • State University of Jakarta
  • National Nuclear Energy Agency of Indonesia
  • University of Liverpool
  • National Research and Innovation Agency
  • Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
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Rekan penulisOrganisasiArtikel bersama
Rini PuspitaningrumState University of Jakarta4
Septelia Inawati WanandiUniversity of Indonesia3
RONDANG ROEMIATI SOEGIANTOUniversitas Kristen Indonesia3
Dwirini Retno GunartiUniversity of Indonesia3
Wardaya WardayaUniversity of Indonesia3
Ani Retno PrijantiUniversity of Indonesia2
Puspita Eka WuyungUniversity of Indonesia2
Sri Nurbowo ArdiUniversity of Indonesia2
Muhammad Arza PutraRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo2
Dewi SukmawatiRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo2
Wiwien Heru WiyonoUniversity of Indonesia2
Iin KurniaNational Nuclear Energy Agency of Indonesia1
Teja KisnantoNational Nuclear Energy Agency of Indonesia1
DARYL ROBERT WILLIAMSUniversity of Liverpool1
Andrew R. CossinsUniversity of Liverpool1
. SUBANDRATEAfiliasi tidak diketahui1
Hanifah RahmiUniversitas Muhammadiyah Prof Dr Hamka1
RusdiAfiliasi tidak diketahui1
Kurnia Nuztir MantoliniState University of Jakarta1
Wahono SumaryonoBadan Pengkajian dan Penerapan Teknologi1
Amarila MalikUniversity of Indonesia1
Trismilah MargonoUniversity of Indonesia1
Abdul Halim SadikinUniversity of Indonesia1
Sri Widia A. JusmanUniversity of Indonesia1
Fitrine EkawastiNational Research and Innovation Agency1
April Hari WardhanaNational Research and Innovation Agency1
Dyah Haryuningtyas SawitriAfiliasi tidak diketahui1
Heri WibowoUniversity of Indonesia1
Mgs. M. Irsan SalehSriwijaya University1
Subandrate SubandrateSriwijaya University1
Hermansyah HermansyahSriwijaya University1
Zen HafySriwijaya University1
Yudianita KesumaSriwijaya University1

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/hayati/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Expression of Hypoxia-Inducible Factor-1α and Myoglobin in Rat Heart as Adaptive Response to Intermittent Hypobaric Hypoxia Exposure</dc:title>
	<dc:creator xml:lang="en">Herawati, Margaretha</dc:creator>
	<dc:creator xml:lang="en">Wardaya, .</dc:creator>
	<dc:creator xml:lang="en">Mulyawan, Wawan</dc:creator>
	<dc:creator xml:lang="en">Farhan, Fanny Septiani</dc:creator>
	<dc:creator xml:lang="en">Ferdinal, Frans</dc:creator>
	<dc:creator xml:lang="en">Jusman, Sri Widia A.</dc:creator>
	<dc:creator xml:lang="en">Sadikin, Mohamad</dc:creator>
	<dc:subject xml:lang="en">intermittent hypobaric hypoxia</dc:subject>
	<dc:subject xml:lang="en">HIF-1a</dc:subject>
	<dc:subject xml:lang="en">Mb</dc:subject>
	<dc:description xml:lang="en">The aim of this study was to investigate the influence of intermittent hypobaric hypoxia on the expression hypoxia adaptation proteins, namely hypoxia inducibla factor-1a (HIF-1a) and myoglobin (Mb). Twenty five male Sprague-Dawley rats were exposed to intermittent hypobaric hypoxia in a hypobaric chamber in Indonesian Air Force Institute of Aviation Medicine, for 49.5 minutes at various low pressure, 1 week interval for 4 times (day 1, 8, 15 and 22). HIF-1α and Mb protein were measured with ELISA. mRNA expression of Mb was measured with one step real time RT-PCR. HIF-1α protein levels increased after induction of hypobaric hypoxia and continues to decrease after induction of intermittent hypobaric hypoxia 3 times (ANOVA, p = 0.0437). mRNA expression and protein of Mb increased after induction of hypobaric hypoxia and continues to decrease after induction of intermittent hypobaric hypoxia 3 times (ANOVA, p = 0.0283; 0.0170), and both are strongly correlated (Pearson, r = 0.6307). The heart of rats adapted to intermittent hypoxia conditions by upregulation the expression of HIF-1a and myoglobin and then both return to normal level.</dc:description>
	<dc:publisher xml:lang="en">Bogor Agricultural University, Indonesia</dc:publisher>
	<dc:date>2018-03-26</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://journal.ipb.ac.id/hayati/article/view/20807</dc:identifier>
	<dc:identifier>10.4308/hjb.24.3.131</dc:identifier>
	<dc:source xml:lang="en">HAYATI Journal of Biosciences; Vol. 24 No. 3 (2017): July 2017; 131</dc:source>
	<dc:source>2086-4094</dc:source>
	<dc:source>1978-3019</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://journal.ipb.ac.id/hayati/article/view/20807/14253</dc:relation>
</oai_dc:dc>