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Behavior, Histopathology and Physiological Responses of Rat Fed Diets Containing Growth Hormone Transgenic Fish Meal

HAYATI Journal of Biosciences · Vol. 26 No. 1 (2019)

DOI
10.4308/hjb.26.1.1
ISSN
2086-4094, 1978-3019
Terbit
2019-05-28
Penerbit
Bogor Agricultural University, Indonesia
Bahasa
eng

Abstrak

The animal model response against genetically modified product may provide food safety information. This study was performed to observe behavior, histopathology and physiological responses of Wistar rat fed on the diet containing growth hormone (GH) transgenic common carp (Cyprinus carpio) meal (Ccm). Thirty rats of three-month-old (BW: 115.67–139.50g) were divided into five treatments (six rats per treatment). The treatments were rats fed on the commercial diet without Ccm (control), a re-pelleted diet containing 15% (NT-15) and 45% non-transgenic Ccm (NT-45), a re-pelleted diet containing 15% (TG-15) and 45% GH transgenic Ccm (TG-45). Rats were kept for three weeks, fed twice a day according to treatment by 30 g/day/rat and water was provided ad-libitum. Rat behavior was observed every day during feeding. Serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyvuric transaminase (SGPT), urea, and creatinine were measured at initial and the end of the experiment. Histology observation was made for liver, kidney, and brain tissues. Our results showed that behavior, histopathology, SGOT, SGPT, urea and creatinine levels of rat fed with control, NT- and TG-Ccm diets were similar. All rats survived until the end of the experiment. Thus, within the dose level of this study, GH transgenic Ccm showed no toxicity or effect on behavior and physiology of Wistar rats.

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  • IPB University
  • Hasanuddin University
  • National Research and Innovation Agency
  • Universitas Gadjah Mada
  • Ministry of Marine Affairs and Fisheries
  • Indonesia Open University
  • Indonesian Institute of Sciences
  • Organisasi lain
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Rekan penulisOrganisasiArtikel bersama
Cece SumantriIPB University6
Niken UlupiIPB University4
Fadjar SatrijaIPB University3
Mia SetiawatiIPB University3
Utut WidyastutiIPB University2
Nur Bambang Priyo UtomoIPB University2
Widya AsmaraUniversitas Gadjah Mada2
Jaka WidadaUniversitas Gadjah Mada2
Isyana KhaerunnisaNational Research and Innovation Agency2
Ekowati HandharyaniIPB University2
Asep GunawanIPB University2
Fadhila Maharani PutriAfiliasi tidak diketahui2
Dinamella WahjuningrumIPB University2
Dian HardianthoAfiliasi tidak diketahui2
Ade SunarmaAfiliasi tidak diketahui2
Melly Pratiwi SetyawatiIPB University1
Andi Aliah HidayaniHasanuddin University1
Dody Dh. TrijunoHasanuddin University1
Yushinta FujayaHasanuddin University1
Basse Siang ParawansaHasanuddin University1
Moh. Tauhid UmarHasanuddin University1
Irmawati IrmawatiHasanuddin University1
Aidah Ambo Ala HusainHasanuddin University1
Asmi Citra Malina A.R. TassakkaHasanuddin University1
Nadiarti NadiartiIndonesia Open University1
Andi ParenrengiNational Research and Innovation Agency1
Tri HandayaniIndonesian Institute of Sciences1
Emma SuryatiNational Research and Innovation Agency1
Reni Agustina LubisIPB University1
Dewi YuniatiIPB University1
Irzal EffendiIPB University1
Shella MarlindaIPB University1
Anna OctaveraIPB University1
Harits Atika AriyatnaNational Research and Innovation Agency1
Sulasy RohmyIPB University1
Shavika MirantiUniversitas Maritim Raja Ali Haji1

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/hayati/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Behavior, Histopathology and Physiological Responses of Rat Fed Diets Containing Growth Hormone Transgenic Fish Meal</dc:title>
	<dc:creator xml:lang="en">Alimuddin, Alimuddin</dc:creator>
	<dc:creator xml:lang="en">Murtini, Sri</dc:creator>
	<dc:creator xml:lang="en">Faridah, Nurly</dc:creator>
	<dc:creator xml:lang="en">Nuryati, Sri</dc:creator>
	<dc:subject xml:lang="en">Behavior</dc:subject>
	<dc:subject xml:lang="en">physiology</dc:subject>
	<dc:subject xml:lang="en">toxicity</dc:subject>
	<dc:subject xml:lang="en">transgenic common carp</dc:subject>
	<dc:subject xml:lang="en">Wistar rat</dc:subject>
	<dc:description xml:lang="en">  The animal model response against genetically modified product may provide food safety information. This study was performed to observe behavior, histopathology and physiological responses of Wistar rat fed on the diet containing growth hormone (GH) transgenic common carp (Cyprinus carpio) meal (Ccm). Thirty rats of three-month-old (BW: 115.67–139.50g) were divided into five treatments (six rats per treatment). The treatments were rats fed on the commercial diet without Ccm (control), a re-pelleted diet containing 15% (NT-15) and 45% non-transgenic Ccm (NT-45), a re-pelleted diet containing 15% (TG-15) and 45% GH transgenic Ccm (TG-45). Rats were kept for three weeks, fed twice a day according to treatment by 30 g/day/rat and water was provided ad-libitum. Rat behavior was observed every day during feeding. Serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyvuric transaminase (SGPT), urea, and creatinine were measured at initial and the end of the experiment. Histology observation was made for liver, kidney, and brain tissues. Our results showed that behavior, histopathology, SGOT, SGPT, urea and creatinine levels of rat fed with control, NT- and TG-Ccm diets were similar. All rats survived until the end of the experiment. Thus, within the dose level of this study, GH transgenic Ccm showed no toxicity or effect on behavior and physiology of Wistar rats.</dc:description>
	<dc:publisher xml:lang="en">Bogor Agricultural University, Indonesia</dc:publisher>
	<dc:date>2019-05-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://journal.ipb.ac.id/hayati/article/view/26253</dc:identifier>
	<dc:identifier>10.4308/hjb.26.1.1</dc:identifier>
	<dc:source xml:lang="en">HAYATI Journal of Biosciences; Vol. 26 No. 1 (2019): January 2019; 1</dc:source>
	<dc:source>2086-4094</dc:source>
	<dc:source>1978-3019</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://journal.ipb.ac.id/hayati/article/view/26253/17014</dc:relation>
</oai_dc:dc>