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Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells

HAYATI Journal of Biosciences · Vol. 26 No. 2 (2019)

DOI
10.4308/hjb.26.2.96
ISSN
2086-4094, 1978-3019
Terbit
2019-10-27
Penerbit
Bogor Agricultural University, Indonesia
Bahasa
eng

Abstrak

Cancer is the second cause of death after cardiovascular diseases in the world. Anticancer prevention used can cause undesirable things. Flavonoids are secondary metabolites derived from natural products that are useful for anticancer treatment. This study was performed to observe the cytotoxic activity of alpinumisoflavone from Erythrina poeppigiana, toward cervical cancer (Hela), colon cancer (WiDr), and hepatoma cancer (HepG2) cells. The cytotoxic activity of alpinumisoflavone was tested using (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) assay. The percentage of cell mortality was calculated and the IC50 was calculated using probit analysis. The result shown that alpinumisoflavone has antiproliferative effect to colon cancer (WiDr), cervical cancer (Hela), and hepatoma cancer (HepG2) cells with the value of IC50 are 5.63, 7.18, and 18.08 µg/ml, respectively. Based on the value of IC50 alpinumisoflavone is very cytotoxic to colon cancer WiDr cell.

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Rekan penulisOrganisasiArtikel bersama
Kindi FarabiPadjadjaran University19
Nurlelasari NurlelasariPadjadjaran University17
Desi HarnetiPadjadjaran University16
Tri MayantiPadjadjaran University14
Al Arofatus NainiPadjadjaran University12
Yoshihito ShionoYamagata University11
Sofa FajriahNational Research and Innovation Agency11
Rani MaharaniPadjadjaran University11
Ace Tatang HidayatPadjadjaran University10
Mohamad Nurul AzmiUniversiti Sains Malaysia6
Darwati DarwatiPadjadjaran University6
Euis JulaehaPadjadjaran University6
Fajar Fauzi AbdullahPadjadjaran University6
Wahyu SafriansyahPadjadjaran University4
Hadi KuncoroMulawarman University4
Dewa Gede KatjaSam Ratulangi University4
Erina HilmayantiPadjadjaran University3
Khalijah AwangUniversity of Malaya3
Risyandi AnwarUniversitas Muhammadiyah Semarang3
Harizon HarizonUniversitas Jambi3
Sandra Amalia RiyadiPadjadjaran University3
Desi Harneti Putri HuspaPadjadjaran University3
Sari PurbayaUniversitas Jenderal Achmad Yani3
Ronny LesmanaPadjadjaran University2
Raihan Fathurrahman HasbillaPadjadjaran University2
Susianti SusiantiPadjadjaran University2
Agus SafariPadjadjaran University2
Ricson P. HutagaolUniversitas Nusa Bangsa2
Muhammad HanafiNational Research and Innovation Agency2
Aprilia Permata SariPadjadjaran University2
Mohamad Azlan NafiahSultan Idris Education University2
Ferry Ferdiansyah SofianPadjadjaran University2
Rurini RetnowatiUniversity of Brawijaya2
Asri Peni WulandariPadjadjaran University2

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/hayati/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells</dc:title>
	<dc:creator xml:lang="en">Herlina, Tati</dc:creator>
	<dc:creator xml:lang="en">Haraswati, Nayla</dc:creator>
	<dc:creator xml:lang="en">Apriani, Riza</dc:creator>
	<dc:creator xml:lang="en">Nishinarizki, Vicki</dc:creator>
	<dc:creator xml:lang="en">Gaffar, Shabarni</dc:creator>
	<dc:creator xml:lang="en">Supratman, Unang</dc:creator>
	<dc:subject xml:lang="en">Erythrina poeppigiana</dc:subject>
	<dc:subject xml:lang="en">alpinumisoflavone</dc:subject>
	<dc:subject xml:lang="en">cytotoxic activity</dc:subject>
	<dc:description xml:lang="en">Cancer is the second cause of death after cardiovascular diseases in the world. Anticancer prevention used can cause undesirable things. Flavonoids are secondary metabolites derived from natural products that are useful for anticancer treatment. This study was performed to observe the cytotoxic activity of alpinumisoflavone from Erythrina poeppigiana, toward cervical cancer (Hela), colon cancer (WiDr), and hepatoma cancer (HepG2) cells. The cytotoxic activity of alpinumisoflavone was tested using (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) assay. The percentage of cell mortality was calculated and the IC50 was calculated using probit analysis. The result shown that alpinumisoflavone has antiproliferative effect to colon cancer (WiDr), cervical cancer (Hela), and hepatoma cancer (HepG2) cells with the value of IC50 are 5.63, 7.18, and 18.08 µg/ml, respectively. Based on the value of IC50 alpinumisoflavone is very cytotoxic to colon cancer WiDr cell.</dc:description>
	<dc:publisher xml:lang="en">Bogor Agricultural University, Indonesia</dc:publisher>
	<dc:date>2019-10-27</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://journal.ipb.ac.id/hayati/article/view/27984</dc:identifier>
	<dc:identifier>10.4308/hjb.26.2.96</dc:identifier>
	<dc:source xml:lang="en">HAYATI Journal of Biosciences; Vol. 26 No. 2 (2019): April 2019; 96</dc:source>
	<dc:source>2086-4094</dc:source>
	<dc:source>1978-3019</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://journal.ipb.ac.id/hayati/article/view/27984/17875</dc:relation>
</oai_dc:dc>