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In Silico Analysis of Protein of Milk, Soybean, and Kefir as Anti- Thrombotic Bioactive Peptide

HAYATI Journal of Biosciences · Vol. 30 No. 2 (2022) · hlm. 216–223

DOI
10.4308/hjb.30.2.216-223
ISSN
2086-4094, 1978-3019
Terbit
2022-12-05
Penerbit
Bogor Agricultural University, Indonesia
Bahasa
eng

Abstrak

Currently, Cardiovascular Diseases (CVDs) cases are increasing significantly in Indonesia and the world. WHO reported that in 2019-related CVD patients accounted for 85%, which increased to 87% in 2021. The cases increased significantly by 2%, which is a significant number as it covered the world population. Stroke is a disease affected by platelets undergoing thrombolysis by the α-thrombin (IIa) receptor with coagulation factors on the heart blood vessel. Chemical or synthesis drugs to treat thrombolytics such as heparin are already available, but they would be harmful if misused. In this study, we focused on the activity, interaction, and prediction of the physicochemical of anti-thrombotic peptides. We found that k-casein from kefir has the highest activity of 0.037 A based on BIOPEP analysis with 17 peptide libraries and molecular docking visualization analysis using PyMol, PyRx, and Discovery Studio for screening the best peptide. ToxinPred and AlgPred showed there are no potentially harmful peptides, but the protein variant of β-conglycinin subunit can be an allergen known to the immune system IgE. In conclusion, the GPR peptide has the highest binding affinity, with a total energy of -6.8 kcal/mol.

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  • University of Brawijaya
  • National Research and Innovation Agency
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Rekan penulisOrganisasiArtikel bersama
Maria UlfahNational Research and Innovation Agency1
Is HeliantiNational Research and Innovation Agency1
Gabriela Christy SabbathiniNational Research and Innovation Agency1
Sri Rezeki WulandariNational Research and Innovation Agency1
Muthia Rahmah DiniUniversity of Brawijaya1

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/hayati/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">In Silico Analysis of Protein of Milk, Soybean, and Kefir as Anti- Thrombotic Bioactive Peptide</dc:title>
	<dc:creator xml:lang="en">Muhammad Ilham Fahri</dc:creator>
	<dc:creator xml:lang="en">Fadilla Sherlyna</dc:creator>
	<dc:creator xml:lang="en">Mochamad Nurcholis</dc:creator>
	<dc:description xml:lang="en">Currently, Cardiovascular Diseases (CVDs) cases are increasing significantly in Indonesia and the world. WHO reported that in 2019-related CVD patients accounted for 85%, which increased to 87% in 2021. The cases increased significantly by 2%, which is a significant number as it covered the world population. Stroke is a disease affected by platelets undergoing thrombolysis by the α-thrombin (IIa) receptor with coagulation factors on the heart blood vessel. Chemical or synthesis drugs to treat thrombolytics such as heparin are already available, but they would be harmful if misused. In this study, we focused on the activity, interaction, and prediction of the physicochemical of anti-thrombotic peptides. We found that k-casein from kefir has the highest activity of 0.037 A based on BIOPEP analysis with 17 peptide libraries and molecular docking visualization analysis using PyMol, PyRx, and Discovery Studio for screening the best peptide. ToxinPred and AlgPred showed there are no potentially harmful peptides, but the protein variant of β-conglycinin subunit can be an allergen known to the immune system IgE. In conclusion, the GPR peptide has the highest binding affinity, with a total energy of -6.8 kcal/mol.</dc:description>
	<dc:publisher xml:lang="en">Bogor Agricultural University, Indonesia</dc:publisher>
	<dc:date>2022-12-05</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://journal.ipb.ac.id/hayati/article/view/41042</dc:identifier>
	<dc:identifier>10.4308/hjb.30.2.216-223</dc:identifier>
	<dc:source xml:lang="en">HAYATI Journal of Biosciences; Vol. 30 No. 2 (2023): March 2023; 216-223</dc:source>
	<dc:source>2086-4094</dc:source>
	<dc:source>1978-3019</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://journal.ipb.ac.id/hayati/article/view/41042/24534</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2023 Muhammad Ilham Fahri, Fadilla Sherlyna, Mochamad Nurcholis</dc:rights>
</oai_dc:dc>