Melola Discovery

← Melola Discovery

Jurnal SINTA 1

Expression of APP, CDK5, and AKT1 Gene Related to Alzheimer Disease in Brain of Long-tailed Macaques

HAYATI Journal of Biosciences · Vol. 31 No. 1 (2023) · hlm. 145–152

DOI
10.4308/hjb.31.1.145-152
ISSN
2086-4094, 1978-3019
Terbit
2023-10-22
Penerbit
Bogor Agricultural University, Indonesia
Bahasa
eng

Abstrak

Amyloid plaques and Neurofibrillary Tangles (NFTs) are known to be key pathological features of Alzheimer disease. To gain a better understanding of this disease, studies were carried out on the Indonesian primates, the long-tailed macaques, using a spontaneous Alzheimer's disease model. Examining and identifying genetic markers involved in plaque formation and NFTs in long-tailed macaques is necessary to reveal their physiological processes. In this study, the expression of genes involved in the development of amyloid plaque (Amyloid Precursor Protein (APP)) and those that control the phosphorylation of tau protein (CDK5 and AKT1) was examined in the long-tailed macaque brain. This study showed that APP, CDK5, and AKT1 may potentially be developed as genetic markers of Alzheimer's disease. Long-tailed macaques exhibited the development of amyloid plaque in the aging brain based on the analysis of the gene expression profile of its biomarker. Furthermore, long-tailed macaques can be optimized for neurodegenerative models.

Jaringan kolaborasi para penulis

40 penulis · 112 tautan kepenulisan bersama · 7 lintas organisasi · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • IPB University
  • Ministry of Agriculture
  • Manado State University
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Arief BoedionoIPB University5
Rudy PriyantoIPB University4
Dondin SajuthiIPB University4
. YulianaAfiliasi tidak diketahui4
Silmi MariyaIPB University4
Krido Brahmo PutroIPB University4
Jakaria JakariaIPB University3
Ronny Rachman NoorIPB University3
Ikhsan SuhendroIPB University3
Dyah Perwitasari‐FarajallahIPB University3
Ekowati HandharyaniIPB University3
Nastiti KusumoriniIPB University2
Entang IskandarIPB University2
Hana Intishar SawitriIPB University2
Tommy Langgeng AbimanyuIPB University2
Hera MaheshwariIPB University2
Mohamad RafiIPB University1
Wildayati WildayatiIPB University1
I Wayan Teguh WibawanIPB University1
Etih SudarnikaIPB University1
Maria Fatima PalupiMinistry of Agriculture1
Revolson Alexius MegeManado State University1
Syahrun Hamdani NasutionIPB University1
Dewi Apri AstutiIPB University1
I Nengah BudiarsaIPB University1
Dedy Duryadi SolihinIPB University1
Sata Yoshida Srie RahayuIPB University1
Ridwan AffandiIPB University1
VENNY FEBRIYANIAfiliasi tidak diketahui1
Tutik WresdiyatiIPB University1
Siti Sa’diahIPB University1
Ridwan AffandiIPB University1
La EddyIPB University1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/hayati/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Expression of APP, CDK5, and AKT1 Gene Related to Alzheimer Disease in Brain of Long-tailed Macaques</dc:title>
	<dc:creator xml:lang="en">Rosmanah, Lis</dc:creator>
	<dc:creator xml:lang="en">Saepuloh, Uus</dc:creator>
	<dc:creator xml:lang="en">Mariya, Sela Septima</dc:creator>
	<dc:creator xml:lang="en">Suparto, Irma Herawati</dc:creator>
	<dc:creator xml:lang="en">Manalu, Wasmen</dc:creator>
	<dc:creator xml:lang="en">Winarto, Adi</dc:creator>
	<dc:creator xml:lang="en">Darusman, Huda Shalahudin</dc:creator>
	<dc:description xml:lang="en">Amyloid plaques and Neurofibrillary Tangles (NFTs) are known to be key pathological features of Alzheimer disease. To gain a better understanding of this disease, studies were carried out on the Indonesian primates, the long-tailed macaques, using a spontaneous Alzheimer's disease model. Examining and identifying genetic markers involved in plaque formation and NFTs in long-tailed macaques is necessary to reveal their physiological processes. In this study, the expression of genes involved in the development of amyloid plaque (Amyloid Precursor Protein (APP)) and those that control the phosphorylation of tau protein (CDK5 and AKT1) was examined in the long-tailed macaque brain. This study showed that APP, CDK5, and AKT1 may potentially be developed as genetic markers of Alzheimer's disease. Long-tailed macaques exhibited the development of amyloid plaque in the aging brain based on the analysis of the gene expression profile of its biomarker. Furthermore, long-tailed macaques can be optimized for neurodegenerative models.</dc:description>
	<dc:publisher xml:lang="en">Bogor Agricultural University, Indonesia</dc:publisher>
	<dc:date>2023-10-22</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://journal.ipb.ac.id/hayati/article/view/43980</dc:identifier>
	<dc:identifier>10.4308/hjb.31.1.145-152</dc:identifier>
	<dc:source xml:lang="en">HAYATI Journal of Biosciences; Vol. 31 No. 1 (2024): January 2024; 145-152</dc:source>
	<dc:source>2086-4094</dc:source>
	<dc:source>1978-3019</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://journal.ipb.ac.id/hayati/article/view/43980/26497</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2023 Lis Rosmanah, Uus Saepuloh, Sela Septima Mariya, Irma Herawati Suparto, Wasmen Manalu, Adi Winarto, Huda Shalahudin Darusman</dc:rights>
</oai_dc:dc>