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Oxidative Stress, Hypoxia-Inducible Factor-1α, and Nuclear Factor-Erythroid 2-Related Factor 2 in the Hearts of Rats Exposed to Intermittent Hypobaric Hypoxia

HAYATI Journal of Biosciences · Vol. 31 No. 1 (2023) · hlm. 39–47

DOI
10.4308/hjb.31.1.39-47
ISSN
2086-4094, 1978-3019
Terbit
2023-09-25
Penerbit
Bogor Agricultural University, Indonesia
Bahasa
eng

Abstrak

Hypobaric hypoxia is situation that might occur to helicopter pilots in Indonesia who must fly at an altitude of more than 3,048 m such as in Papua. It can be dangerous because hypoxic condition can affect person's performance. So far, the heart is known as an aerobic organ and very sensitive to hypoxic conditions. Hitherto, the effects of hypobaric hypoxia exposure on biomolecular aspects of the heart are still unclear. Therefore, this study assessed cardiac response in rats exposed to intermittent hypobaric hypoxia (IHH) (equivalent to 3,048 meters/10,000 feet). Sprague-Dawley rats were divided into six groups: control; acute hypobaric hypoxia (AHH); and IHH, for 7; 14; 21; and 28 days. We measured super oxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities, reduced glutathione (GSH), malondialdehyde (MDA), cytoglobin, myoglobin, HIF-1α, and Nrf2 level as our parameters. Activities of SOD, CAT, GPx and GSH increased while the levels of MDA, cytoglobin, myoglobin, HIF-1α, and Nrf2 decreased in all IHH groups compared with the AHH group. A biphasic pattern was observed as IHH sessions increased from 14 to 21 or 28. Where the IHH treatment for more than 14 sessions caused a decrease in endogenous antioxidants, but the response to hypoxia and oxidative stress increased. Our findings presented the molecular alterations of cardiac rats exposed to intermittent hypobaric hypoxia.

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RINI PUSPITANINGRUMAfiliasi tidak diketahui4
. WardayaAfiliasi tidak diketahui4
SEPTELIA INAWATI WANANDIAfiliasi tidak diketahui3
RONDANG ROEMIATI SOEGIANTOAfiliasi tidak diketahui3
DWIRINI RETNO GUNARTIAfiliasi tidak diketahui3
Margaretha HerawatiAfiliasi tidak diketahui3
Fanny Septiani FarhanAfiliasi tidak diketahui3
Frans FerdinalAfiliasi tidak diketahui3
Toar Jean Maurice LalisangAfiliasi tidak diketahui1
Ridho Ardhi SyaifulAfiliasi tidak diketahui1
Novi Silvia HardianyAfiliasi tidak diketahui1
Yefta MoenadjatAfiliasi tidak diketahui1
DARYL ROBERT WILLIAMSAfiliasi tidak diketahui1
ANDREW ROBERT COSSINSAfiliasi tidak diketahui1
. SUBANDRATEAfiliasi tidak diketahui1
Hanifah RahmiAfiliasi tidak diketahui1
RusdiAfiliasi tidak diketahui1
KURNIA NUZTIR MANTOLINIAfiliasi tidak diketahui1
WAHONO SUMARYONOAfiliasi tidak diketahui1
AMARILA MALIKAfiliasi tidak diketahui1
Trismilah MargonoAfiliasi tidak diketahui1
Ani Retno PrijantiAfiliasi tidak diketahui1
Abdul Halim SadikinAfiliasi tidak diketahui1
Sri Widia Azraki JusmanAfiliasi tidak diketahui1
Dewi SukmawatiAfiliasi tidak diketahui1
Puspita Eka WuyungAfiliasi tidak diketahui1
Sri Nurbowo ArdiAfiliasi tidak diketahui1
Muhammad Arza PutraAfiliasi tidak diketahui1
Wiwien Heru WiyonoAfiliasi tidak diketahui1
Hermansyah HermansyahAfiliasi tidak diketahui1
Mgs. M. Irsan SalehAfiliasi tidak diketahui1
Subandrate SubandrateAfiliasi tidak diketahui1
Zen HafyAfiliasi tidak diketahui1
Yudianita KesumaAfiliasi tidak diketahui1
K KartiniAfiliasi tidak diketahui1
Ahmad A JusufAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/hayati/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Oxidative Stress, Hypoxia-Inducible Factor-1α, and Nuclear Factor-Erythroid 2-Related Factor 2 in the Hearts of Rats Exposed to Intermittent Hypobaric Hypoxia</dc:title>
	<dc:creator xml:lang="en">Wardaya, Wardaya</dc:creator>
	<dc:creator xml:lang="en">Mulyawan, Wawan</dc:creator>
	<dc:creator xml:lang="en">Jusman, Sri Widia A</dc:creator>
	<dc:creator xml:lang="en">Sadikin, Mohamad</dc:creator>
	<dc:description xml:lang="en">Hypobaric hypoxia is situation that might occur to helicopter pilots in Indonesia who must fly at an altitude of more than 3,048 m such as in Papua. It can be dangerous because hypoxic condition can affect person's performance. So far, the heart is known as an aerobic organ and very sensitive to hypoxic conditions. Hitherto, the effects of hypobaric hypoxia exposure on biomolecular aspects of the heart are still unclear. Therefore, this study assessed cardiac response in rats exposed to intermittent hypobaric hypoxia (IHH) (equivalent to 3,048 meters/10,000 feet). Sprague-Dawley rats were divided into six groups: control; acute hypobaric hypoxia (AHH); and IHH, for 7; 14; 21; and 28 days. We measured super oxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities, reduced glutathione (GSH), malondialdehyde (MDA), cytoglobin, myoglobin, HIF-1α, and Nrf2 level as our parameters. Activities of SOD, CAT, GPx and GSH increased while the levels of MDA, cytoglobin, myoglobin, HIF-1α, and Nrf2 decreased in all IHH groups compared with the AHH group. A biphasic pattern was observed as IHH sessions increased from 14 to 21 or 28. Where the IHH treatment for more than 14 sessions caused a decrease in endogenous antioxidants, but the response to hypoxia and oxidative stress increased. Our findings presented the molecular alterations of cardiac rats exposed to intermittent hypobaric hypoxia.</dc:description>
	<dc:publisher xml:lang="en">Bogor Agricultural University, Indonesia</dc:publisher>
	<dc:date>2023-09-25</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://journal.ipb.ac.id/hayati/article/view/47925</dc:identifier>
	<dc:identifier>10.4308/hjb.31.1.39-47</dc:identifier>
	<dc:source xml:lang="en">HAYATI Journal of Biosciences; Vol. 31 No. 1 (2024): January 2024; 39-47</dc:source>
	<dc:source>2086-4094</dc:source>
	<dc:source>1978-3019</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://journal.ipb.ac.id/hayati/article/view/47925/26309</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2023 Wardaya Wardaya, Wawan Mulyawan, Sri Widia A Jusman, Mohamad Sadikin</dc:rights>
</oai_dc:dc>