Melola Discovery

← Melola Discovery

Jurnal SINTA 1

Immune Response to Capsular Polysaccharide of Streptococcus pneumoniae in Rabbits Immunized with Pneumococcal Conjugate Vaccine

HAYATI Journal of Biosciences · Vol. 32 No. 3 (2025) · hlm. 642–648

DOI
10.4308/hjb.32.3.642-648
ISSN
2086-4094, 1978-3019
Terbit
2025-01-24
Penerbit
Bogor Agricultural University, Indonesia
Bahasa
eng

Abstrak

To evaluate the immune response of a rabbit model to polysaccharide capsules of Streptococcus pneumoniae after primary and booster immunization with pneumococcal conjugate vaccine. Rabbits were immunized with 0.25 ml of the 13-valent pneumococcal conjugate vaccine (PCV13) on Day 0, 7, and 14. Blood of rabbits was collected to measure the specific antibodies against the native polysaccharide capsules of S. pneumoniae serotypes 6B (Anti-Pn6BPS antibodies) and 19F (Anti-19FPS antibodies) using enzyme-linked immunosorbent assay (ELISA). The specific anti-Pn6BPS and anti-Pn19FPS antibodies in the immunized group increased significantly compared to the control rabbit after immunization (P<0.05). The highest titer of anti-Pn6BPS and anti-Pn19FPS antibodies were obtained on Day 21 and Day 28, respectively. The third immunization on Day 21 is a fairly high increase in specific antibodies against polysaccharide type 6B and type 19F. The highest antibody titers against polysaccharide capsules of S. pneumoniae were obtained after booster immunization.

Jaringan kolaborasi para penulis

22 penulis · 65 tautan kepenulisan bersama · 40 lintas organisasi

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • University of Indonesia
  • Eijkman Institute for Molecular Biology
  • Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
  • Universitas Trisakti
  • Universitas Pembangunan Nasional Veteran Jakarta
  • Amsterdam University Medical Centers
  • National Research and Innovation Agency
  • Organisasi lain
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Yeva RosanaUniversity of Indonesia2
Ida EffendiUniversitas Trisakti2
Wresti IndriatmiRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo2
Tina KusumaningrumEijkman Institute for Molecular Biology2
Septiani Madonna GultomRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo2
Nina Dwi PutriRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo2
Cut Nurul HafifahRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo2
Oktania Sandra PuspitaUniversitas Pembangunan Nasional Veteran Jakarta1
Beti Ernawati DewiUniversity of Indonesia1
Muhammad Choirul HidajatNational Research and Innovation Agency1
Muhammad Hussein GasemDiponegoro University1
Farida Dwi HandayaniUniversity of Indonesia1
Lisa NovipuspitasariAfiliasi tidak diketahui1
Ahmed AhmedAmsterdam University Medical Centers1
Amin SoebandrioUniversity of Indonesia1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/hayati/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Immune Response to Capsular Polysaccharide of Streptococcus pneumoniae in Rabbits Immunized with Pneumococcal Conjugate Vaccine</dc:title>
	<dc:creator xml:lang="en">Zaenab</dc:creator>
	<dc:creator xml:lang="en">Tafroji, Wisnu </dc:creator>
	<dc:creator xml:lang="en">Salsabila, Korrie </dc:creator>
	<dc:creator xml:lang="en"> Winarti, Yayah</dc:creator>
	<dc:creator xml:lang="en">Wulandari, I Gusti Ayu Inten </dc:creator>
	<dc:creator xml:lang="en"> Yasmon, Andi</dc:creator>
	<dc:creator xml:lang="en">Safari, Dodi</dc:creator>
	<dc:description xml:lang="en">To evaluate the immune response of a rabbit model to polysaccharide capsules of Streptococcus pneumoniae after primary and booster immunization with pneumococcal conjugate vaccine. Rabbits were immunized with 0.25 ml of the 13-valent pneumococcal conjugate vaccine (PCV13) on Day 0, 7, and 14. Blood of rabbits was collected to measure the specific antibodies against the native polysaccharide capsules of S. pneumoniae serotypes 6B (Anti-Pn6BPS antibodies) and 19F (Anti-19FPS antibodies) using enzyme-linked immunosorbent assay (ELISA). The specific anti-Pn6BPS and anti-Pn19FPS antibodies in the immunized group increased significantly compared to the control rabbit after immunization (P&amp;lt;0.05). The highest titer of anti-Pn6BPS and anti-Pn19FPS antibodies were obtained on Day 21 and Day 28, respectively. The third immunization on Day 21 is a fairly high increase in specific antibodies against polysaccharide type 6B and type 19F. The highest antibody titers against polysaccharide capsules of S. pneumoniae were obtained after booster immunization.</dc:description>
	<dc:publisher xml:lang="en">Bogor Agricultural University, Indonesia</dc:publisher>
	<dc:date>2025-01-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://journal.ipb.ac.id/hayati/article/view/51033</dc:identifier>
	<dc:identifier>10.4308/hjb.32.3.642-648</dc:identifier>
	<dc:source xml:lang="en">HAYATI Journal of Biosciences; Vol. 32 No. 3 (2025): May 2025; 642-648</dc:source>
	<dc:source>2086-4094</dc:source>
	<dc:source>1978-3019</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://journal.ipb.ac.id/hayati/article/view/51033/30057</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Zaenab , Wisnu  Tafroji, Korrie  Salsabila, Yayah  Winarti, I Gusti Ayu Inten  Wulandari, Andi  Yasmon, Dodi Safari</dc:rights>
</oai_dc:dc>