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LC-HRMS-Based Metabolomics for Profiling the Metabolites in Different Plant Parts of Centella asiatica

HAYATI Journal of Biosciences · Vol. 31 No. 6 (2024) · hlm. 1106–1115

DOI
10.4308/hjb.31.6.1106-1115
ISSN
2086-4094, 1978-3019
Terbit
2024-08-20
Penerbit
Bogor Agricultural University, Indonesia
Bahasa
eng

Abstrak

Centella asiatica, or pegagan in Indonesia, is a perennial plant used in Indonesian traditional medicine (jamu) and functional food with many biological activities. Those biological activities come from the bioactive metabolites present in C. asiatica. Differences in metabolite pathways in each part of the plant affect the accumulation of metabolites contained, thus impacting its biological activity. Therefore, this study aims to identify and evaluate differences in the distribution of metabolites in each part of C. asiatica, namely leaves, stems, stolons, and roots. Each plant part was extracted using methanol and sonicated for 30 minutes. The metabolites in the samples were separated and detected using UHPLC-Q-Orbitrap HRMS. Differences in the distribution of metabolites in each part of the plant were evaluated using chemometrics analysis. UHPLC-Q-Orbitrap HRMS analysis could positively identify 37 metabolites, most of which belong to the phenylpropanoid, triterpenoid, triterpenoid saponin, and flavonoid groups. Principal component analysis was able to clearly distinguish each part of the plant using the peak intensity of the overall chromatogram and the peak area of the identified metabolites. The different biosynthetic pathways of metabolites in plants could cause a difference in the distribution of metabolites in each plant.

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Auliya IlmiawatiAfiliasi tidak diketahui5
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Agus SaputraAfiliasi tidak diketahui3
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Zulkarnain JalilAfiliasi tidak diketahui2
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Tuti BahfiartiHasanuddin University1
Alem Febri SonniAfiliasi tidak diketahui1
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Puji HardatiAfiliasi tidak diketahui1
Widia Citra AnggundariAfiliasi tidak diketahui1
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Denny SetiawanUniversity of Indonesia1
Della Raymena JovankaAfiliasi tidak diketahui1
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Saiful RidloState University of Semarang1
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Azharuddin AzharuddinAfiliasi tidak diketahui1
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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/hayati/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">LC-HRMS-Based Metabolomics for Profiling the Metabolites in Different Plant Parts of Centella asiatica</dc:title>
	<dc:creator xml:lang="en">Rafi, Mohamad</dc:creator>
	<dc:creator xml:lang="en">Madya, Muhammad Miftahul</dc:creator>
	<dc:creator xml:lang="en">Karomah, Alfi Hudatul</dc:creator>
	<dc:creator xml:lang="en">Septaningsih, Dewi Anggraini</dc:creator>
	<dc:creator xml:lang="en">Ridwan, Taopik</dc:creator>
	<dc:creator xml:lang="en">Rohaeti, Eti</dc:creator>
	<dc:creator xml:lang="en">Aisyah, Siti</dc:creator>
	<dc:creator xml:lang="en">Idroes, Rinaldi</dc:creator>
	<dc:description xml:lang="en">Centella asiatica, or pegagan in Indonesia, is a perennial plant used in Indonesian traditional medicine (jamu) and functional food with many biological activities. Those biological activities come from the bioactive metabolites present in C. asiatica. Differences in metabolite pathways in each part of the plant affect the accumulation of metabolites contained, thus impacting its biological activity. Therefore, this study aims to identify and evaluate differences in the distribution of metabolites in each part of C. asiatica, namely leaves, stems, stolons, and roots. Each plant part was extracted using methanol and sonicated for 30 minutes. The metabolites in the samples were separated and detected using UHPLC-Q-Orbitrap HRMS. Differences in the distribution of metabolites in each part of the plant were evaluated using chemometrics analysis. UHPLC-Q-Orbitrap HRMS analysis could positively identify 37 metabolites, most of which belong to the phenylpropanoid, triterpenoid, triterpenoid saponin, and flavonoid groups. Principal component analysis was able to clearly distinguish each part of the plant using the peak intensity of the overall chromatogram and the peak area of the identified metabolites. The different biosynthetic pathways of metabolites in plants could cause a difference in the distribution of metabolites in each plant.</dc:description>
	<dc:publisher xml:lang="en">Bogor Agricultural University, Indonesia</dc:publisher>
	<dc:date>2024-08-20</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://journal.ipb.ac.id/hayati/article/view/52923</dc:identifier>
	<dc:identifier>10.4308/hjb.31.6.1106-1115</dc:identifier>
	<dc:source xml:lang="en">HAYATI Journal of Biosciences; Vol. 31 No. 6 (2024): November 2024; 1106-1115</dc:source>
	<dc:source>2086-4094</dc:source>
	<dc:source>1978-3019</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://journal.ipb.ac.id/hayati/article/view/52923/28794</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Mohamad Rafi, Muhammad Miftahul Madya, Alfi Hudatul Karomah, Dewi Anggraini Septaningsih, Taopik Ridwan, Eti Rohaeti, Siti Aisyah, Rinaldi Idroes</dc:rights>
</oai_dc:dc>