The Antiaging Potential of Serum Formulations from Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA on Injured Human Fibroblast Cells

Girsang, Ermi; Wargasetia, Teresa Liliana; Rahmat, Deni; Gondokesumo, Marisca Evalina; Harjanti, Mathelda Weni; Widowati, Wahyu; Zahiroh, Fadhilah Haifa; Saufa, Zahra Qisthi; Takasenserang, Oktaviana; Hadiprasetyo, Dhanar Septyawan

doi:10.4308/hjb.32.3.623-631

Jurnal SINTA 1

The Antiaging Potential of Serum Formulations from Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA on Injured Human Fibroblast Cells

HAYATI Journal of Biosciences · Vol. 32 No. 3 (2025) · hlm. 623–631

DOI: 10.4308/hjb.32.3.623-631
ISSN: 2086-4094, 1978-3019
Terbit: 2025-01-24
Penerbit: Bogor Agricultural University, Indonesia
Bahasa: eng

Abstrak

External aging factors such as UV exposure, pollution, and lifestyle choices contribute to skin aging, resulting in deep wrinkles, fine lines, and rough skin, which can lower self-confidence. Plant extracts have been widely studied for their antiaging potential, while Salmon DNA has shown promise in stimulating collagen production. This study explores the formulation of a serum combining Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA for its antiaging effects on injured human fibroblast cells. The serum was formulated using extracts from C. asiatica, C. longa, A. vera, R. centifolia, and Salmon DNA. Antioxidant activity was evaluated with the DPPH method, cytotoxicity using the WST-8 assay, and gene expression through qRT-PCR for COL1A1, TGF-β1, HYAL-1, and FGF-2. The serum exhibited weak antioxidant activity (IC50 = 373.33 µg/ml) and reduced cell viability at high concentrations. Gene expression analysis revealed increased expression of COL1A1, TGF-β1, and FGF-2, along with reduced HYAL-1 expression in injured BJ cells. The formulated serum shows potential as an antiaging agent, promoting collagen production and reducing hyaluronidase activity.

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Universitas Prima Indonesia
Maranatha Christian University
Bandung Institute of Technology
University of Indonesia
Indonesian Institute of Sciences
Padjadjaran University
Pancasila University
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Afiliasi tidak diketahui

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Organisasi sama
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Tampilkan sebagai tabel

Rekan penulis	Organisasi	Artikel bersama
Rizal Rizal	University of Indonesia	11
Hanna Sari Widya Kusuma	Afiliasi tidak diketahui	11
Rizal Azis	University of Indonesia	8
Chrismis Novalinda Ginting	Universitas Prima Indonesia	7
I Nyoman Ehrich Lister	Universitas Prima Indonesia	7
Ervi Afifah	Afiliasi tidak diketahui	5
Tjandrawati Mozef	Indonesian Institute of Sciences	5
Didik Priyandoko	Indonesia University of Education	5
Annisa Amalia	Bandung Institute of Technology	4
Diana Krisanti Jasaputra	Maranatha Christian University	4
The Fransiska Eltania	Maranatha Christian University	4
Ahmad Faried	Padjadjaran University	4
Wahyu Setia Widodo	Afiliasi tidak diketahui	4
Hana Ratnawati	Maranatha Christian University	3
Chandra Risdian	Indonesian Institute of Sciences	3
Ali Napiah Nasution	Universitas Prima Indonesia	3
Nadya Nazimuddin Putri	Universitas Prima Indonesia	2
Sri Lestari Ramadhani Nasution	Universitas Prima Indonesia	2
Lusiana Darsono	Maranatha Christian University	2
Seila Arumwardana	Afiliasi tidak diketahui	2
Ika Adhani Sholihah	Bandung Institute of Technology	2
Philips Onggowidjaja	Maranatha Christian University	2
Agung Novianto	Padjadjaran University	2
Ferry Sandra	Universitas Trisakti	2
Dwi Davidson Rihibiha	Afiliasi tidak diketahui	2
Harry Murti	Afiliasi tidak diketahui	2
Indra Bachtiar	Afiliasi tidak diketahui	2
Putri Peggy Yanti Kosasih	Afiliasi tidak diketahui	1
Agnes Hartantio	Afiliasi tidak diketahui	1
Putranto Manalu	Universitas Prima Indonesia	1

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/hayati/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.

Metadata asli (oai_dc)

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	<dc:title xml:lang="en">The Antiaging Potential of Serum Formulations from Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA on Injured Human Fibroblast Cells</dc:title>
	<dc:creator xml:lang="en">Girsang, Ermi</dc:creator>
	<dc:creator xml:lang="en">Wargasetia, Teresa Liliana</dc:creator>
	<dc:creator xml:lang="en">Rahmat, Deni</dc:creator>
	<dc:creator xml:lang="en">Gondokesumo, Marisca Evalina</dc:creator>
	<dc:creator xml:lang="en">Harjanti, Mathelda Weni</dc:creator>
	<dc:creator xml:lang="en">Widowati, Wahyu</dc:creator>
	<dc:creator xml:lang="en">Zahiroh, Fadhilah Haifa</dc:creator>
	<dc:creator xml:lang="en">Saufa, Zahra Qisthi</dc:creator>
	<dc:creator xml:lang="en">Takasenserang, Oktaviana</dc:creator>
	<dc:creator xml:lang="en">Hadiprasetyo, Dhanar Septyawan </dc:creator>
	<dc:description xml:lang="en">External aging factors such as UV exposure, pollution, and lifestyle choices contribute to skin aging, resulting in deep wrinkles, fine lines, and rough skin, which can lower self-confidence. Plant extracts have been widely studied for their antiaging potential, while Salmon DNA has shown promise in stimulating collagen production. This study explores the formulation of a serum combining Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA for its antiaging effects on injured human fibroblast cells. The serum was formulated using extracts from C. asiatica, C. longa, A. vera, R. centifolia, and Salmon DNA. Antioxidant activity was evaluated with the DPPH method, cytotoxicity using the WST-8 assay, and gene expression through qRT-PCR for COL1A1, TGF-β1, HYAL-1, and FGF-2. The serum exhibited weak antioxidant activity (IC50 = 373.33 µg/ml) and reduced cell viability at high concentrations. Gene expression analysis revealed increased expression of COL1A1, TGF-β1, and FGF-2, along with reduced HYAL-1 expression in injured BJ cells. The formulated serum shows potential as an antiaging agent, promoting collagen production and reducing hyaluronidase activity.</dc:description>
	<dc:publisher xml:lang="en">Bogor Agricultural University, Indonesia</dc:publisher>
	<dc:date>2025-01-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://journal.ipb.ac.id/hayati/article/view/59888</dc:identifier>
	<dc:identifier>10.4308/hjb.32.3.623-631</dc:identifier>
	<dc:source xml:lang="en">HAYATI Journal of Biosciences; Vol. 32 No. 3 (2025): May 2025; 623-631</dc:source>
	<dc:source>2086-4094</dc:source>
	<dc:source>1978-3019</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://journal.ipb.ac.id/hayati/article/view/59888/30052</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Ermi Girsang, Teresa Liliana Wargasetia, Deni Rahmat, Marisca Evalina Gondokesumo, Mathelda Weni Harjanti, Wahyu Widowati, Fadhilah Haifa Zahiroh, Zahra Qisthi Saufa, Oktaviana Takasenserang, Dhanar Septyawan  Hadiprasetyo</dc:rights>
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