Jurnal SINTA 1
The Role of Colchicine in Acute Coronary Syndrome
Heart Science Journal · Vol. 1 No. 4 (2020) · hlm. 4–8
- ISSN
- 2721-9984, 2721-9976
- Terbit
- 2020-12-23
- Penerbit
- Universitas Brawijaya
- Bahasa
- en
Abstrak
Background: Despite the advances of current optimal treatment of atherosclerotic disease, the incidence of events after acute coronary syndrome (ACS) remains high. Colchicine, with its well-established pleiotropic anti-inflam- matory effects, may inhibit NLRP3 inflammasome, a key mediator in atherosclerosis-associated inflammation (AAI) thus reducing systemic inflammation. NRLP3 inflammasome activation inside leukocytes (mainly monocytes and neutrophils) is precipitated by cholesterol crystals that are present in all atherosclerosis stages. ô°Ÿô°‹ô°¡ô°ˆô°‡ô±Žô°‹ô°‡ô°†ô°‚ ô°ô°€ô°‚ô°…ô°©ô°ô°‚ô°…ô°ƒô°† ô°ƒô°œ ô°¢ô°Žô°ƒô°ô°…ô°†ô°œô°ô°ô°ô°ô°ô°‚ô°ƒô°Žô° ô°€ô°ô°‚ô°ƒô°„ô°…ô°†ô°‡ô°ˆ ô°ˆô°‹ô°€ô°Œ ô°ô°ˆ ô°…ô°†ô°‚ô°‡ô°Žô°ô°‡ô°‹ô°„ô°…ô°†ô°ô°‘ô°’ ô°ô°†ô°— ô°…ô°†ô°‚ô°‡ô°Žô°ô°‡ô°‹ô°„ô°…ô°†ô°ô°‘ô°£ ô°³ô°…ô°ô° ô°œô°ƒô°ô°ô°ƒô°³ô°¨ ô°˜ô°Œô°‡ô°ˆô°‡Â cytokines are the crucial inflammatory pathway mediators that promote the formation of plaque and instability in the inflammatory cascade.Objective: This review will elaborate on the function of immune cells in atherosclerosis, explain the mechanisms of NLRP3 inflammasome activation in the context of AAI, and address the possible role of colchicine specifically targeting NLRP3 inflammasome and its concomitant downstream mediators in ACS, and provide an overview of current or ongoing studies produced in this area.DiscussionÂ: NRLP3 inflammasome activation inside leukocytes (mainly monocytes and neutrophils) is precipitat- ed by cholesterol crystals that are present in all atherosclerosis stages. Subsequent activation of pro-inflammatory ô°€ô°ô°‚ô°ƒô°„ô°…ô°†ô°‡ô°ˆ ô°ˆô°‹ô°€ô°Œ ô°ô°ˆ ô°…ô°†ô°‚ô°‡ô°Žô°ô°‡ô°‹ô°„ô°…ô°†ô°ô°‘ô°’ ô°ô°†ô°— ô°…ô°†ô°‚ô°‡ô°Žô°ô°‡ô°‹ô°„ô°…ô°†ô°ô°‘ô°£ ô°³ô°…ô°ô° ô°œô°ƒô°ô°ô°ƒô°³ô°¨ ô°˜ô°Œô°‡ô°ˆô°‡ ô°€ô°ô°‚ô°ƒô°„ô°…ô°†ô°‡ô°ˆ ô°ô°Žô°‡ ô°‚ô°Œô°‡ ô°€ô°Žô°‹ô°€ô°…ô°ô° ô°…ô°†ô°œô°ô°ô°ô°ô°ô°‚ô°ƒô°Žô°Â pathway mediators that promote the formation of plaque and instability in the inflammatory cascade. A potential advantage of a medication acting through an inflammatory milieu found in atherosclerotic lesions has recently become the need for novel therapeutic options. Colchicine, with its well-established pleiotropic anti-inflammato- ry effects, may inhibit NLRP3 inflammasome, a key mediator in atherosclerosis-associated inflammation (AAI) thus reducing systemic inflammation.Conclusion: Colchicine is a safe and reliable medication for ACS patients, alongside reveal various benefit in reducing inflammation through inhibition of NLRP3 Inflammasome`
Kata kunci
Jaringan kolaborasi para penulis
40 penulis · 287 tautan kepenulisan bersama · 13 lintas organisasi · menampilkan 40 yang paling banyak terhubung
Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.
- University of Brawijaya
- RSUD Prof. Dr. Saiful Anwar Malang
- Afiliasi tidak diketahui
- Organisasi berbeda
- Organisasi sama
- Afiliasi tidak diketahui
- Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
| Rekan penulis | Organisasi | Artikel bersama |
|---|---|---|
| Mohammad Saifur Rohman | University of Brawijaya | 44 |
| Setyasih Anjarwani | University of Brawijaya | 31 |
| Anna Fuji Rahimah | University of Brawijaya | 25 |
| Novi Kurnianingsih | University of Brawijaya | 23 |
| Cholid Tri Tjahjono | University of Brawijaya | 22 |
| Ardian Rizal | University of Brawijaya | 16 |
| Sasmojo Widito | University of Brawijaya | 14 |
| Heny Martini | University of Brawijaya | 12 |
| Muhammad Rizki Fadlan | University of Brawijaya | 7 |
| Putri Annisa Kamila | University of Brawijaya | 6 |
| Wella Karolina | University of Brawijaya | 5 |
| Yoga Waranugraha | University of Brawijaya | 5 |
| Tria Yudha Nugraha | University of Brawijaya | 4 |
| Hayla Iqda Millisani | University of Brawijaya | 4 |
| Valerinna Yogibuana | Afiliasi tidak diketahui | 4 |
| Anna Fuji Rahimah | Afiliasi tidak diketahui | 4 |
| Yudi Putra Apriditya | University of Brawijaya | 4 |
| Teguh Aryanugraha | University of Brawijaya | 4 |
| Muhammad Saifur Rohman | Afiliasi tidak diketahui | 4 |
| Danti Utami Setyowati | RSUD Prof. Dr. Saiful Anwar Malang | 3 |
| Dadang Hendrawan | University of Brawijaya | 3 |
| Dea Arie Kurniawan | University of Brawijaya | 3 |
| Seprian Widasmara | University of Brawijaya | 3 |
| Valerinna Yogibuana Swastika Putri | University of Brawijaya | 3 |
| Shalahuddin Suryo Baskoro | University of Brawijaya | 3 |
| Lutfi Hafiz Zunardi | University of Brawijaya | 3 |
| Yuri Afifah | University of Brawijaya | 3 |
| Yoseph Budi Utomo | University of Brawijaya | 3 |
| Ayu Asri Devi Adityawati | University of Brawijaya | 3 |
| Harris Kristanto | University of Brawijaya | 2 |
| Taufieq Ridlo Makhmud | University of Brawijaya | 2 |
| Faris Wahyu Nugroho | University of Brawijaya | 2 |
| Anita Surya Santoso | Afiliasi tidak diketahui | 2 |
| Imelda Krisnasari | University of Brawijaya | 2 |
| Nikhen Noverike | University of Brawijaya | 2 |
| Imam Mi'raj Suprayoga | University of Brawijaya | 2 |
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