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Validation of Saiful Anwar Clinical Congestion Score in Comparison with NT-proBNP for Prediction of Short-term Outcome in Acute Heart Failure with Reduced Ejection Fraction

Heart Science Journal · Vol. 1 No. 4 (2020) · hlm. 25–30

DOI
10.21776/ub.hsj.2020.001.04.06
ISSN
2721-9984, 2721-9976
Terbit
2020-12-23
Penerbit
Universitas Brawijaya
Bahasa
en

Abstrak

Background: Risk stratification of acute heart failure (AHF) patient during hospital admission utilizing clinical scores emerges as an alternative to standart natriuretic peptide measurement. Development of Saiful Anwar clinical congestion score (SACS) as multivariable predictive model for prediction of short-term outcome in AHF with reduced ejection fraction (AHF-rEF) requires validation in comparison to NT-proBNP.Objective: To validate prognostic value of SACS compare with NT-proBNP in AHF-rEFMethod: This single-center, prospective cohort study was held in dr. Saiful Anwar General Hospital during January 2019 to June 2020. From total 89 AHF-rEF patients who admitted to emergency department, were assigned to SACS prospective questionnaire fulfillment and NT-proBNP measurement during first 12-hours since admission. Patients were divided into two groups based on SACS score and NT-proBNP value during admission. 90-days follow up was performed after index hospitalization with outcome of interest i.e all-cause mortality (ACM) and HF-related rehospitalization (HFR).Results: ACM and HFR rate in this study were 16.8% and 22.5%, respectively. SACS ≥6 demonstrated higher ACM and HFR rate during 90-days follow-up compared to SACS <6 (p=0.000; p=0.000, respectively). Performance of SACS ≥6 on admission showed good discriminative power for predicting 90-days ACM and HFR (AUC 0.841, p=0.000; AUC 0.788, p=0.000, respectively) compared to NT-proBNP ≥5000pg/mL (AUC 0.812, p=0.000; AUC 0.819, p=0.000, respectively). Additive value of NT-proBNP ≥5000pg/mL on top of SACS ≥6 increases discriminative power for predicting 90-days ACM and HFR after index hospitalization (AUC 0.836, p=0.000; AUC 0.90, p=0.000, respectively).Comclusion: SACS has demonstrated prognostic value compared to NT-proBNP for prediction of 90-days ACM and HFR after index hospitalization in AHF-rEF patients.

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  • University of Brawijaya
  • RSUD Prof. Dr. Saiful Anwar Malang
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
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Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Ardian RizalUniversity of Brawijaya43
Budi SatrijoUniversity of Brawijaya40
Indra PrasetyaUniversity of Brawijaya40
Djanggan SargowoUniversity of Brawijaya39
Setyasih AnjarwaniUniversity of Brawijaya37
Heny MartiniUniversity of Brawijaya35
Sasmojo WiditoUniversity of Brawijaya33
Yoga WaranugrahaUniversity of Brawijaya16
Wella KarolinaUniversity of Brawijaya12
Adhika Prastya WikanandaUniversity of Brawijaya9
Valerinna YogibuanaAfiliasi tidak diketahui9
Tri AstiawatiUniversity of Brawijaya8
Nikhen NoverikeUniversity of Brawijaya8
Putri Annisa KamilaUniversity of Brawijaya7
Seprian WidasmaraUniversity of Brawijaya7
Ratna PancasariUniversity of Brawijaya7
Ayu Asri Devi AdityawatiUniversity of Brawijaya7
Oktafin Srywati PamunaUniversity of Brawijaya6
Imelda KrisnasariUniversity of Brawijaya6
Valerinna Yogibuana Swastika PutriUniversity of Brawijaya6
Ira Vori NugrohoUniversity of Brawijaya6
Dadang HendrawanUniversity of Brawijaya5
Fandy HazzyUniversity of Brawijaya5
Anna Fuji RahimahAfiliasi tidak diketahui5
Fahmy RusnantaUniversity of Brawijaya5
Arif Ranu WicaksonoUniversity of Brawijaya5
Teguh AryanugrahaUniversity of Brawijaya5
Sawitri SatwikajatiUniversity of Brawijaya4
Saskia Dyah HandariUniversity of Brawijaya4
Olivia HandayaniUniversity of Brawijaya4
Krishna Ari NugrahaUniversity of Brawijaya4
Evit RuspionoAfiliasi tidak diketahui4
Imam Mi'raj SuprayogaUniversity of Brawijaya4
Dea Arie KurniawanUniversity of Brawijaya4

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Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Validation of Saiful Anwar Clinical Congestion Score in Comparison with NT-proBNP for Prediction of Short-term Outcome in Acute Heart Failure with Reduced Ejection Fraction</dc:title>
	<dc:creator xml:lang="en">Adrian, Liemena Harold</dc:creator>
	<dc:creator xml:lang="en">Rohman, Mohammad Saifur</dc:creator>
	<dc:creator xml:lang="en">Fadlan, Muhammad Rizki</dc:creator>
	<dc:creator xml:lang="en">Tjahjono, Cholid Tri</dc:creator>
	<dc:creator xml:lang="en">Rahimah, Anna Fuji</dc:creator>
	<dc:creator xml:lang="en">Kurnianingsih, Novi</dc:creator>
	<dc:subject xml:lang="en">acute heart failure</dc:subject>
	<dc:subject xml:lang="en">reduced ejection fraction</dc:subject>
	<dc:subject xml:lang="en">clinical score</dc:subject>
	<dc:subject xml:lang="en">NT-proBNP</dc:subject>
	<dc:subject xml:lang="en">mortality</dc:subject>
	<dc:subject xml:lang="en">rehospitalization</dc:subject>
	<dc:description xml:lang="en">Background : Risk stratification of acute heart failure (AHF) patient during hospital admission utilizing clinical scores emerges as an alternative to standart natriuretic peptide measurement. Development of Saiful Anwar clinical congestion score (SACS) as multivariable predictive model for prediction of short-term outcome in AHF with reduced ejection fraction (AHF-rEF) requires validation in comparison to NT-proBNP.Objective : To validate prognostic value of SACS compare with NT-proBNP in AHF-rEFMethod : This single-center, prospective cohort study was held in dr. Saiful Anwar General Hospital during January 2019 to June 2020. From total 89 AHF-rEF patients who admitted to emergency department, were assigned to SACS prospective questionnaire fulfillment and NT-proBNP measurement during first 12-hours since admission. Patients were divided into two groups based on SACS score and NT-proBNP value during admission. 90-days follow up was performed after index hospitalization with outcome of interest i.e all-cause mortality (ACM) and HF-related rehospitalization (HFR).Results : ACM and HFR rate in this study were 16.8% and 22.5%, respectively. SACS ≥6 demonstrated higher ACM and HFR rate during 90-days follow-up compared to SACS &amp;lt;6 (p=0.000; p=0.000, respectively). Performance of SACS ≥6 on admission showed good discriminative power for predicting 90-days ACM and HFR (AUC 0.841, p=0.000; AUC 0.788, p=0.000, respectively) compared to NT-proBNP ≥5000pg/mL (AUC 0.812, p=0.000; AUC 0.819, p=0.000, respectively). Additive value of NT-proBNP ≥5000pg/mL on top of SACS ≥6 increases discriminative power for predicting 90-days ACM and HFR after index hospitalization (AUC 0.836, p=0.000; AUC 0.90, p=0.000, respectively).Comclusion : SACS has demonstrated prognostic value compared to NT-proBNP for prediction of 90-days ACM and HFR after index hospitalization in AHF-rEF patients.</dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2020-12-23</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/148</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2020.001.04.06</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 1 No. 4 (2020): Acute Coronary Syndrome in Daily Practice : Diagnosis, Complication, and Management; 25-30</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2020.001.04</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/148/310</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2020 Liemena Harold Adrian</dc:rights>
</oai_dc:dc>