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Role of LAVi/A’ and E/’ as A Predictor of Major Adverse Cardiac Event on Patient with Acute Myocardial Infraction with ST Segment Elevation Undergo Through Percutaneous Coronary Intervention

Heart Science Journal · Vol. 2 No. 1 (2021) · hlm. 30–35

DOI
10.21776/ub.hsj.2021.002.01.05
ISSN
2721-9984, 2721-9976
Terbit
2021-02-28
Penerbit
Universitas Brawijaya
Bahasa
en

Abstrak

Introduction:STEMI is still a major health problem in industrialized and developing countries. The risk of adverse cardiovascular events remains substansial and may vary significantly across of STEMI patients. Echocardiography is recommended tool for diagnosis and predict outcomes. Increased LA volume index (LAVI) has been shown to be a powerfull predictor of mortality after AMI. The ratio of the  left atrial volume index (LAVI) and late diastolic mitral annular velocity (A’) is additional benefits in the assessment od advance diastolic dysfunction in ACS for predicting outcome.Methods:This study retrospective cohort was conducted in patient admitted to Saiful Anawar General Hospital with STEMI who undergo PCI from 2019-2020. All patient underwent echocardiography measurement within 24-48 hours and we follow-up patient for 6 months until 12 months. Echocardiography measurement that we conducted were LVEF, E/A, E/e’, LAVI/A’ and LV diastolic function were measured according to ASE guidelines. All of the patients were given standard medical therapy. Patients who did not adhere to medication were excluded. The study endpoints were hospitalisation and mortality because of cardiac problem. Result:We collected the data from 169 STEMI patients. However, about 39 STEMI patients were excluded because of incomplete data, lost follow-up, become atrial fibrillation, refused participation and death. Finally, a total of 130 patients were involved in the analysis process. The patients mean age was 61.48 ± 7 years, and 78% of them were male. The receiver operating characteristics curve indicated that LAVI/A’ ≥ 4.0 predicted these events (AUC 0.892, 95% CI 0.819-0.965) and E/e’  ≥ was 13.4 (AUC 0.874, 95% CI; 0.806-0.942). The MACE incident in 6 months with LAVI/A’ ≥ 4.0 was 40%, E/e’ ≥ 13.4 was 20% and LAVI/A’ ≥ 4.0 + E/e’ ≥ 13.4 was higher 60%. The incidence MACE incident was LAVI/A’ > 4.0 sensitivity 92% and specifity 88% (CI 95%), E/e’ > 13.4 sensitivity 80% and specifity 74% (CI 95%), LAVI/A’ > 4.0 + E/e’ > 13.4 sensitivity 92% and specifity 88% (CI 95%). Conlussion:The LAVI/A’ ratio is available as echo index which reflects LV chronic diastolic function in patient with STEMI. It can predict MACE, particularly in those with STEMI undergo PCI. Combined LAVI/A’ > 4.0 and E/e’ >13,4 ratio suggests MACE better than LAVI/A’ > 4.0 and E/e’ >13,4 alone.Keywords: ST-elevation Myocardial Infarction, Echocardiography, LAVI/A’, E/e’, Percutaneous Coronary Intervention

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  • University of Brawijaya
  • RSUD Prof. Dr. Saiful Anwar Malang
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Rekan penulisOrganisasiArtikel bersama
Mohammad Saifur RohmanUniversity of Brawijaya65
Novi KurnianingsihUniversity of Brawijaya37
Setyasih AnjarwaniUniversity of Brawijaya31
Indra PrasetyaUniversity of Brawijaya27
Heny MartiniUniversity of Brawijaya24
Sasmojo WiditoUniversity of Brawijaya24
Ardian RizalUniversity of Brawijaya23
Yoga WaranugrahaUniversity of Brawijaya12
Wella KarolinaUniversity of Brawijaya9
Valerinna YogibuanaAfiliasi tidak diketahui8
Teguh AryanugrahaUniversity of Brawijaya7
Saskia Dyah HandariUniversity of Brawijaya6
Putri Annisa KamilaUniversity of Brawijaya6
Ayu Asri Devi AdityawatiUniversity of Brawijaya6
Valerinna Yogibuana Swastika PutriUniversity of Brawijaya6
Nikhen NoverikeUniversity of Brawijaya5
Lukitasari Ayu Galuh ArdhiUniversity of Brawijaya5
Dadang HendrawanUniversity of Brawijaya5
Anna Fuji RahimahAfiliasi tidak diketahui5
Liemena Harold AdrianRSUD Prof. Dr. Saiful Anwar Malang5
Ratna PancasariUniversity of Brawijaya4
Imelda KrisnasariUniversity of Brawijaya4
Olivia HandayaniUniversity of Brawijaya4
Veny KurniawatiUniversity of Brawijaya3
Dea Arie KurniawanUniversity of Brawijaya3
Arif Ranu WicaksonoUniversity of Brawijaya3
Tri AstiawatiUniversity of Brawijaya3
Zainal FathurohimUniversity of Brawijaya3
Dedy IrawanUniversity of Brawijaya3
Imam Mi'raj SuprayogaUniversity of Brawijaya3
Tonny AdriyantoUniversity of Brawijaya2
Oktafin Srywati PamunaUniversity of Brawijaya2
Krishna Ari NugrahaUniversity of Brawijaya2
Adhika Prastya WikanandaUniversity of Brawijaya2

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Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Role of LAVi/A’ and E/’ as A Predictor of Major Adverse Cardiac Event on Patient with Acute Myocardial Infraction with ST Segment Elevation Undergo Through Percutaneous  Coronary Intervention</dc:title>
	<dc:creator xml:lang="en">Pratama, Aditya Reza</dc:creator>
	<dc:creator xml:lang="en">Satrijo, Budi</dc:creator>
	<dc:creator xml:lang="en">Rahimah, Anna Fuji</dc:creator>
	<dc:creator xml:lang="en">Sargowo, Djanggan</dc:creator>
	<dc:creator xml:lang="en">Tjahjono, Cholid Tri</dc:creator>
	<dc:creator xml:lang="en">Fadlan, Muhammad Rizki Rizki</dc:creator>
	<dc:subject xml:lang="en">ST-elevation Myocardial Infarction</dc:subject>
	<dc:subject xml:lang="en">Echocardiography</dc:subject>
	<dc:subject xml:lang="en">LAVI/A’</dc:subject>
	<dc:subject xml:lang="en">E/e’</dc:subject>
	<dc:subject xml:lang="en">Percutaneous Coronary Intervention</dc:subject>
	<dc:description xml:lang="en">Introduction:STEMI is still a major health problem in industrialized and developing countries. The risk of adverse cardiovascular events remains substansial and may vary significantly across of STEMI patients. Echocardiography is recommended tool for diagnosis and predict outcomes. Increased LA volume index (LAVI) has been shown to be a powerfull predictor of mortality after AMI. The ratio of the  left atrial volume index (LAVI) and late diastolic mitral annular velocity (A’) is additional benefits in the assessment od advance diastolic dysfunction in ACS for predicting outcome.Methods:This study retrospective cohort was conducted in patient admitted to Saiful Anawar General Hospital with STEMI who undergo PCI from 2019-2020. All patient underwent echocardiography measurement within 24-48 hours and we follow-up patient for 6 months until 12 months. Echocardiography measurement that we conducted were LVEF, E/A, E/e’, LAVI/A’ and LV diastolic function were measured according to ASE guidelines. All of the patients were given standard medical therapy. Patients who did not adhere to medication were excluded. The study endpoints were hospitalisation and mortality because of cardiac problem. Result:We collected the data from 169 STEMI patients. However, about 39 STEMI patients were excluded because of incomplete data, lost follow-up, become atrial fibrillation, refused participation and death. Finally, a total of 130 patients were involved in the analysis process. The patients mean age was 61.48 ± 7 years, and 78% of them were male. The receiver operating characteristics curve indicated that LAVI/A’ ≥ 4.0 predicted these events (AUC 0.892, 95% CI 0.819-0.965) and E/e’  ≥ was 13.4 (AUC 0.874, 95% CI; 0.806-0.942). The MACE incident in 6 months with LAVI/A’ ≥ 4.0 was 40%, E/e’ ≥ 13.4 was 20% and LAVI/A’ ≥ 4.0 + E/e’ ≥ 13.4 was higher 60%. The incidence MACE incident was LAVI/A’ &amp;gt; 4.0 sensitivity 92% and specifity 88% (CI 95%), E/e’ &amp;gt; 13.4 sensitivity 80% and specifity 74% (CI 95%), LAVI/A’ &amp;gt; 4.0 + E/e’ &amp;gt; 13.4 sensitivity 92% and specifity 88% (CI 95%). Conlussion:The LAVI/A’ ratio is available as echo index which reflects LV chronic diastolic function in patient with STEMI. It can predict MACE, particularly in those with STEMI undergo PCI. Combined LAVI/A’ &amp;gt; 4.0 and E/e’ &amp;gt;13,4 ratio suggests MACE better than LAVI/A’ &amp;gt; 4.0 and E/e’ &amp;gt;13,4 alone.Keywords: ST-elevation Myocardial Infarction, Echocardiography, LAVI/A’, E/e’, Percutaneous Coronary Intervention</dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2021-02-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/151</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2021.002.01.05</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 2 No. 1 (2021): How to Diagnose Heart Failure and Deal with The Treatment Complexity; 30-35</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2021.002.01</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/151/301</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2021 Aditya Reza Pratama, Budi Satrijo, Anna Fuji Rahimah, Djanggan Sargowo, Cholid Tri Tjahjono, Muhammad Rizki Rizki Fadlan</dc:rights>
</oai_dc:dc>