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Profile of Pediatric Rheumatic Heart Disease Patients with Mitral Regurgitation Receiving Angiotensin-Converting Enzyme Inhibitor in dr. Saiful Anwar General Hospital Malang

Heart Science Journal · Vol. 2 No. 2 (2021) · hlm. 9–14

DOI
10.21776/ub.hsj.2021.002.02.3
ISSN
2721-9984, 2721-9976
Terbit
2021-04-29
Penerbit
Universitas Brawijaya
Bahasa
en

Abstrak

AbstractBackground: Rheumatic heart disease (RHD) remains the leading cause of heart failure in children worldwide. Long-term consequences and sequelae of acute rheumatic fever may further contributes to isolated mitral regurgitation (MR), unless promptly treated, may develop to extensive fibrosis and calcification leading to mitral stenosis. ACE inhibitor through reverse remodeling mechanisms may encounter secondary LV changes due to rheumatic MR. Studies in the field of RHD remain limited, particularly in Indonesia. Method: This observational descriptive study recruited 69 pediatric patients diagnosed with RHD who went to Pediatric Cardiology Clinic of dr. Saiful Anwar General Hospital during November 2018 to June 2019. A total of 22 patients were excluded due to incomplete data or showing no MR during echocardiography. The remaining samples (47 patients) were divided into two groups i.e: captopril and no captopril group. Data regarding profile of baseline characteristics, parameter of LV remodeling (dimension, mass and geometry), and grading of MR were collected then tabulated using descriptive statistical analysis. Results: In general, from total 47 of sample population, female sex was found to predominate (68%), with mean age of 12.1 years and body mass index (BMI) 17.2 kg/m2. Proportion of distribution among captopril and no captopril group demonstrated no significant difference (p>0.05). Captopril group revealed younger age, higher BMI and longer time of initial RHD diagnosis compared to no captopril group. Evaluation of LV remodeling parameter demonstrated that captopril group had smaller LVIDd, lower LVMI, higher fractional shortening (FS) and higher LVEF. LVPWd dan RWT were found to be relatively similar among both groups. Evaluation of MR grade revealed that captopril group showed lower value of MR VC, MR EROA and MR regurgitant volume. Conclusion: Profile of pediatric RHD patients with MR who had been receiving captopril for at least 12 months in dr. Saiful Anwar General Hospital during period of 2018-2019 demonstrated younger age, higher BMI, smaller LVIDd, lower LVMI, lower MR grade, higher FS and higher LVEF compared to patients who had not. Keywords: rheumatic heart disease, mitral regurgitation, ACE inhibitor, captopril, left ventricle remodeling

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  • University of Brawijaya
  • RSUD Prof. Dr. Saiful Anwar Malang
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
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Rekan penulisOrganisasiArtikel bersama
Mohammad Saifur RohmanUniversity of Brawijaya37
Setyasih AnjarwaniUniversity of Brawijaya26
Anna Fuji RahimahUniversity of Brawijaya22
Heny MartiniUniversity of Brawijaya17
Novi KurnianingsihUniversity of Brawijaya15
Sasmojo WiditoUniversity of Brawijaya14
Budi SatrijoUniversity of Brawijaya13
Djanggan SargowoUniversity of Brawijaya10
Cholid Tri TjahjonoUniversity of Brawijaya9
Wella KarolinaUniversity of Brawijaya8
Tria Yudha NugrahaUniversity of Brawijaya5
Icmi Dian RochmawatiUniversity of Brawijaya5
Valerinna YogibuanaAfiliasi tidak diketahui5
Adhika Prastya WikanandaUniversity of Brawijaya4
Danti Utami SetyowatiRSUD Prof. Dr. Saiful Anwar Malang4
Yoga WaranugrahaUniversity of Brawijaya3
Hayla Iqda MillisaniUniversity of Brawijaya3
Putri Annisa KamilaUniversity of Brawijaya3
Fahmy RusnantaUniversity of Brawijaya3
Anita Surya SantosoAfiliasi tidak diketahui3
Seprian WidasmaraUniversity of Brawijaya3
Tri AstiawatiUniversity of Brawijaya3
Valerinna Yogibuana Swastika PutriUniversity of Brawijaya3
Shalahuddin Suryo BaskoroUniversity of Brawijaya3
Puspa LestariUniversity of Brawijaya2
Olivia HandayaniUniversity of Brawijaya2
Fitranti Suciati LaitupaUniversity of Brawijaya2
Yudi Putra ApridityaUniversity of Brawijaya2
Lutfi Hafiz ZunardiUniversity of Brawijaya2
N KaputrinUniversity of Brawijaya2
Anna Fuji RahimahAfiliasi tidak diketahui2
Ratna PancasariUniversity of Brawijaya2
Dea Arie KurniawanUniversity of Brawijaya2
Lukitasari Ayu Galuh ArdhiUniversity of Brawijaya2

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Profile of Pediatric Rheumatic Heart Disease Patients with Mitral Regurgitation Receiving Angiotensin-Converting Enzyme Inhibitor in dr. Saiful Anwar General Hospital Malang</dc:title>
	<dc:creator xml:lang="en">Nugroho, Faris Wahyu</dc:creator>
	<dc:creator xml:lang="en">Rohman, Muhammad Saifur</dc:creator>
	<dc:creator xml:lang="en">Rizal, Ardian</dc:creator>
	<dc:creator xml:lang="en">Martini, Heny</dc:creator>
	<dc:creator xml:lang="en">Prasetya, Indra</dc:creator>
	<dc:creator xml:lang="en">Makhmud, Taufieq Ridlo</dc:creator>
	<dc:subject xml:lang="en">rheumatic heart disease</dc:subject>
	<dc:subject xml:lang="en">mitral regurgitation</dc:subject>
	<dc:subject xml:lang="en">ACE inhibitor</dc:subject>
	<dc:subject xml:lang="en">captopril</dc:subject>
	<dc:subject xml:lang="en">left ventricle remodeling</dc:subject>
	<dc:description xml:lang="en">AbstractBackground : Rheumatic heart disease (RHD) remains the leading cause of heart failure in children worldwide. Long-term consequences and sequelae of acute rheumatic fever may further contributes to isolated mitral regurgitation (MR), unless promptly treated, may develop to extensive fibrosis and calcification leading to mitral stenosis.  ACE inhibitor through reverse remodeling mechanisms may encounter secondary LV changes due to rheumatic MR. Studies in the field of RHD remain limited, particularly in Indonesia. Method : This observational descriptive study recruited 69 pediatric patients diagnosed with RHD who went to Pediatric Cardiology Clinic of dr. Saiful Anwar General Hospital during November 2018 to June 2019. A total of 22 patients were excluded due to incomplete data or showing no MR during echocardiography. The remaining samples (47 patients) were divided into two groups i.e: captopril and no captopril group. Data regarding profile of baseline characteristics, parameter of LV remodeling (dimension, mass and geometry), and grading of MR  were collected then tabulated using descriptive statistical analysis. Results : In general, from total 47 of sample population, female sex was found to predominate (68%), with mean age of 12.1 years and body mass index (BMI) 17.2 kg/m2. Proportion of distribution among captopril and no captopril group demonstrated no significant difference (p&amp;gt;0.05). Captopril group revealed younger age, higher BMI and longer time of initial RHD diagnosis compared to no captopril group. Evaluation of LV remodeling parameter demonstrated that captopril group had smaller LVIDd, lower LVMI, higher fractional shortening (FS) and higher LVEF. LVPWd dan RWT were found to be relatively similar among both groups. Evaluation of MR grade revealed that captopril group showed lower value of MR VC, MR EROA and MR regurgitant volume. Conclusion : Profile of pediatric RHD patients with MR who had been receiving captopril for at least 12 months in dr. Saiful Anwar General Hospital during period of 2018-2019 demonstrated younger age, higher BMI, smaller LVIDd, lower LVMI, lower MR grade, higher FS and higher LVEF compared to patients who had not. Keywords: rheumatic heart disease, mitral regurgitation, ACE inhibitor, captopril, left ventricle remodeling</dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2021-04-29</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/158</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2021.002.02.3</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 2 No. 2 (2021): Dealing with Vascular Disease; 9-14</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2021.002.02</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/158/291</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2021 Faris Wahyu Nugroho, Muhammad Saifur Rohman, Ardian Rizal, Heny Martini, Indra Prasetya, Taufieq Ridlo Makhmud</dc:rights>
</oai_dc:dc>