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Left Atrial Emptying Fraction as Precictor Parameter of Major Adverse Cardiovascular Events (MACE) and Decrease of Functional Capacity in Patients With STEMI Treated by Primary Percutaneous Coronary Intervention

Heart Science Journal · Vol. 3 No. 2 (2022) · hlm. 18–23

DOI
10.21776/ub.hsj.2022.003.02.4
ISSN
2721-9984, 2721-9976
Terbit
2022-04-30
Penerbit
Universitas Brawijaya
Bahasa
en

Abstrak

Background: HF is common following ST-elevated myocardial infarction (STEMI) and aasociated with morbidity and mortality. Echocardiography is routine examination and commonly utilized for risk stratification. In current guideline. Enlarged LA volume, doppler parameter, and tissue doppler imaging were used for diastolic dysfunction. However, they have several limitation. LAEF may be superior to LAVI, doppler parameter, or TDI  as markers of cardiac function in acute phase after AMI. This study conducted to assess the LAEF in predicting death, rehospitalization of heart failure (HF), and decrease functional capacity after STEMI.Methods and Results: Between January 2018 and January 2021, 391 patients with STEMI who got primary percutaneous coronary intervention were included. After STEMI, patients had echocardiography within 48 hours. All of the patients were subjected to standardized 2-dimensional echocardiography procedures. The LAEF was determined by dividing the maximal LA volume by the minimal LA volume. The primary endpoint of this study was a Major Adverse Cardiovascular Events that consisting of all-cause death and rehospitalization because decompensation of heart failure within 12 months. The secondary end point was decline of functional capacity within 12 months. During the 12-month follow-up period, 162 individuals developed MACE. Only LAEF remained an independent predictor of MACE after adjusting for clinical, biochemical, and echocardiographic factors. (P = 0.000, Odds Ratio 15,46 (CI 95%: 9,264 – 26,409)). For secondary end point, there was a significant difference in the number of patients experiencing decreased functional capacity between the groups with LAEF ≥37.5% and LAEF <37.5% (based on cut off value)  in the 6-month range (p=0.000 ) and was consistent within 12 months (p=0.000).Conclusion: LAEF can be a predictor of MACE and decline functional capacity of STEMI patients who have undergone primary PCI within 12 months.

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  • University of Brawijaya
  • RSUD Prof. Dr. Saiful Anwar Malang
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Rekan penulisOrganisasiArtikel bersama
Mohammad Saifur RohmanUniversity of Brawijaya35
Cholid Tri TjahjonoUniversity of Brawijaya18
Indra PrasetyaUniversity of Brawijaya18
Ardian RizalUniversity of Brawijaya16
Setyasih AnjarwaniUniversity of Brawijaya16
Djanggan SargowoUniversity of Brawijaya16
Novi KurnianingsihUniversity of Brawijaya14
Heny MartiniUniversity of Brawijaya11
Sasmojo WiditoUniversity of Brawijaya11
Wella KarolinaUniversity of Brawijaya6
Muhammad Rizki FadlanUniversity of Brawijaya6
Nikhen NoverikeUniversity of Brawijaya5
Valerinna YogibuanaAfiliasi tidak diketahui5
Lukitasari Ayu Galuh ArdhiUniversity of Brawijaya4
Yoga WaranugrahaUniversity of Brawijaya4
Valerinna Yogibuana Swastika PutriUniversity of Brawijaya4
Putri Annisa KamilaUniversity of Brawijaya3
Dea Arie KurniawanUniversity of Brawijaya3
Ayu Asri Devi AdityawatiUniversity of Brawijaya3
Imelda KrisnasariUniversity of Brawijaya3
Teguh AryanugrahaUniversity of Brawijaya3
Veny KurniawatiUniversity of Brawijaya2
Ratna PancasariUniversity of Brawijaya2
Anna Fuji RahimahAfiliasi tidak diketahui2
Shalahuddin Suryo BaskoroUniversity of Brawijaya2
Tri AstiawatiUniversity of Brawijaya2
N KaputrinUniversity of Brawijaya2
Muhammad Saifur RohmanAfiliasi tidak diketahui2
Merlita HerbaniUniversity of Brawijaya2
Olivia HandayaniUniversity of Brawijaya2
Liemena Harold AdrianRSUD Prof. Dr. Saiful Anwar Malang2
Seprian WidasmaraUniversity of Brawijaya2
Lutfi Hafiz ZunardiUniversity of Brawijaya2
Imam Mi'raj SuprayogaUniversity of Brawijaya2
Emil FathoniUniversity of Brawijaya2
Marco FilanoUniversity of Brawijaya2
Yoseph Budi UtomoUniversity of Brawijaya1

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Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Left Atrial Emptying Fraction as Precictor Parameter of Major Adverse Cardiovascular Events (MACE) and Decrease of Functional Capacity in Patients With STEMI Treated by Primary Percutaneous Coronary Intervention</dc:title>
	<dc:creator xml:lang="en">Kristanto, Harris</dc:creator>
	<dc:creator xml:lang="en">Satrijo, Budi</dc:creator>
	<dc:creator xml:lang="en">Rahimah, Anna Fuji</dc:creator>
	<dc:subject xml:lang="en">STEMI</dc:subject>
	<dc:subject xml:lang="en">echocardiography</dc:subject>
	<dc:subject xml:lang="en">left atrial emptying fraction</dc:subject>
	<dc:subject xml:lang="en">MACE</dc:subject>
	<dc:subject xml:lang="en">functional capacity</dc:subject>
	<dc:description xml:lang="en">Background: HF is common following ST-elevated myocardial infarction (STEMI) and aasociated with morbidity and mortality. Echocardiography is routine examination and commonly utilized for risk stratification. In current guideline. Enlarged LA volume, doppler parameter, and tissue doppler imaging were used for diastolic dysfunction. However, they have several limitation. LAEF may be superior to LAVI, doppler parameter, or TDI  as markers of cardiac function in acute phase after AMI. This study conducted to assess the LAEF in predicting death, rehospitalization of heart failure (HF), and decrease functional capacity after STEMI.Methods and Results: Between January 2018 and January 2021, 391 patients with STEMI who got primary percutaneous coronary intervention were included. After STEMI, patients had echocardiography within 48 hours. All of the patients were subjected to standardized 2-dimensional echocardiography procedures. The LAEF was determined by dividing the maximal LA volume by the minimal LA volume. The primary endpoint of this study was a Major Adverse Cardiovascular Events that consisting of all-cause death and rehospitalization because decompensation of heart failure within 12 months. The secondary end point was decline of functional capacity within 12 months. During the 12-month follow-up period, 162 individuals developed MACE. Only LAEF remained an independent predictor of MACE after adjusting for clinical, biochemical, and echocardiographic factors. (P = 0.000, Odds Ratio 15,46 (CI 95%: 9,264 – 26,409)). For secondary end point, there was a significant difference in the number of patients experiencing decreased functional capacity between the groups with LAEF ≥37.5% and LAEF &amp;lt;37.5% (based on cut off value)  in the 6-month range (p=0.000 ) and was consistent within 12 months (p=0.000).Conclusion: LAEF can be a predictor of MACE and decline functional capacity of STEMI patients who have undergone primary PCI within 12 months.</dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2022-04-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/1334</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2022.003.02.4</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 3 No. 2 (2022): Improving ST-Elevation Myocardial Infraction Patients Prognosis; 18-23</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2022.003.02</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/1334/258</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2022 Harris Kristanto, Budi Satrijo, Anna Fuji Rahimah</dc:rights>
</oai_dc:dc>