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The Impact of Successful Percutaneous Coronary Intervention on the Reduction of Major Cardiovascular Events in Patients with Chronic Total Coronary Occlusion In dr. Saiful Anwar's Malang Hospital

Heart Science Journal · Vol. 3 No. 3 (2022) · hlm. 25–32

DOI
10.21776/ub.hsj.2022.003.03.5
ISSN
2721-9984, 2721-9976
Terbit
2022-07-28
Penerbit
Universitas Brawijaya
Bahasa
en

Abstrak

Background: Chronic total coronary occlusion (CTOs) is associated with an increased risk of adverse clinical outcomes. The benefits of percutaneous coronary intervention (PCI) in CTO are still being debated due to the limited data available. This study aims to determine the relationship between the success of PCI in CTOs and the reduction of major cardiovascular events compared to those who failed or did not perform revascularization in patients with chronic coronary total occlusion in RSUD by Dr. Saiful Anwar Malang. Methods:This study is an analytic observational study with a retrospective cohort design. Of a total of 2165 patients who underwent angiography at Saiful Anwar Hospital, Malang, for the period August 2017–September 2020, consecutively, 578 patients with lesions of at least one CTO were found. There were 68 patients who were excluded, so 510 patients were analyzed in this study. They were divided into two groups, the CTO group that was successfully revascularized with PCI (n = 141) and the group that was not revascularized (n = 369). The outcome of this study was major cardiovascular events (MACE), which included cardiac mortality, all cause mortality, and rehospitalization events. Result: Patients with CTO who were not revascularized compared to those with revascularized CTO had a higher history of heart failure, involvement of LM disease, multivessel disease, and three vessel disease (41.2% vs 18.4%, p = 0.041; 16.5% vs 1.8%, p < 0.001; 69.4% vs 22.7%, p < 0.001; 56.5% vs 14.1%, p < 0.001) with a lower mean LVEF (0.49 ± 0.06 vs 0.51 ± 0.07, p=0.045) and older age (60±9 vs 57±8 years; p=0.007).. At a 12-month follow-up, in the CTO group that was successfully revascularized by PCI, there was a better prognosis than the non-revascularized CTO group in terms of major cardiovascular events (19.9% vs 33.1% Plog-rank = 0.002). These results were consistent for all-cause mortality (5.5% vs 20.6%, Plog-rank =0.027), cardiac mortality (3.7% vs 20.6%, Plog-rank < 0.001) and rehospitalization events. (7.5% vs 32.2%, Plog-rank = 0.001). Conclusion: Successful revascularization of CTO by PCI may provide clinical benefits in patients with CTO in association with major cardiovascular events.

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Rekan penulisOrganisasiArtikel bersama
Cholid Tri TjahjonoUniversity of Brawijaya46
Indra PrasetyaUniversity of Brawijaya43
Setyasih AnjarwaniUniversity of Brawijaya36
Sasmojo WiditoUniversity of Brawijaya32
Djanggan SargowoUniversity of Brawijaya32
Heny MartiniUniversity of Brawijaya32
Budi SatrijoUniversity of Brawijaya31
Yoga WaranugrahaUniversity of Brawijaya15
Wella KarolinaUniversity of Brawijaya14
Adhika Prastya WikanandaUniversity of Brawijaya12
Nikhen NoverikeUniversity of Brawijaya10
Tri AstiawatiUniversity of Brawijaya9
Valerinna YogibuanaAfiliasi tidak diketahui8
Putri Annisa KamilaUniversity of Brawijaya8
Seprian WidasmaraUniversity of Brawijaya8
Muhammad Rizki FadlanUniversity of Brawijaya7
Ayu Asri Devi AdityawatiUniversity of Brawijaya7
Fandy HazzyUniversity of Brawijaya6
Fahmy RusnantaUniversity of Brawijaya6
Valerinna Yogibuana Swastika PutriUniversity of Brawijaya6
Olivia HandayaniUniversity of Brawijaya5
Oktafin Srywati PamunaUniversity of Brawijaya5
Imelda KrisnasariUniversity of Brawijaya5
Imam Mi'raj SuprayogaUniversity of Brawijaya5
Dea Arie KurniawanUniversity of Brawijaya5
Dadang HendrawanUniversity of Brawijaya4
Sawitri SatwikajatiUniversity of Brawijaya4
Lukitasari Ayu Galuh ArdhiUniversity of Brawijaya4
Icmi Dian RochmawatiUniversity of Brawijaya4
Anna Fuji RahimahAfiliasi tidak diketahui4
Ira Vori NugrohoUniversity of Brawijaya4
Teguh AryanugrahaUniversity of Brawijaya4
Arif Ranu WicaksonoUniversity of Brawijaya4
Hayla Iqda MillisaniUniversity of Brawijaya3
Lutfi Hafiz ZunardiUniversity of Brawijaya3

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Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">The Impact of Successful Percutaneous Coronary Intervention on the Reduction of Major Cardiovascular Events in Patients with Chronic Total Coronary Occlusion In dr. Saiful Anwar's Malang Hospital</dc:title>
	<dc:creator xml:lang="en">Pancasari, Ratna</dc:creator>
	<dc:creator xml:lang="en">Rohman, Mohammad Saifur</dc:creator>
	<dc:creator xml:lang="en">Rizal, Ardian</dc:creator>
	<dc:creator xml:lang="en">Kurnianingsih, Novi</dc:creator>
	<dc:creator xml:lang="en">Rahimah, Anna Fuji</dc:creator>
	<dc:subject xml:lang="en">Chronic coronary total occlusion (CTO)</dc:subject>
	<dc:subject xml:lang="en">major cardiovascular events</dc:subject>
	<dc:subject xml:lang="en">percutaneous coronary intervention (PCI)</dc:subject>
	<dc:subject xml:lang="en">revascularization.</dc:subject>
	<dc:description xml:lang="en">Background: Chronic total coronary occlusion (CTOs) is associated with an increased risk of adverse clinical outcomes. The benefits of percutaneous coronary intervention (PCI) in CTO are still being debated due to the limited data available. This study aims to determine the relationship between the success of PCI in CTOs and the reduction of major cardiovascular events compared to those who failed or did not perform revascularization in patients with chronic coronary total occlusion in RSUD by Dr. Saiful Anwar Malang. Methods:This study is an analytic observational study with a retrospective cohort design. Of a total of 2165 patients who underwent angiography at Saiful Anwar Hospital, Malang, for the period August 2017–September 2020, consecutively, 578 patients with lesions of at least one CTO were found. There were 68 patients who were excluded, so 510 patients were analyzed in this study. They were divided into two groups, the CTO group that was successfully revascularized with PCI (n = 141) and the group that was not revascularized (n = 369). The outcome of this study was major cardiovascular events (MACE), which included cardiac mortality , all cause mortality, and rehospitalization events. Result: Patients with CTO who were not revascularized compared to those with revascularized CTO had a higher history of heart failure, involvement of LM disease, multivessel disease, and three vessel disease (41.2% vs 18.4%, p = 0.041; 16.5% vs 1.8%, p &amp;lt; 0.001; 69.4% vs 22.7%, p &amp;lt; 0.001; 56.5% vs 14.1%, p &amp;lt; 0.001) with a lower mean LVEF (0.49 ± 0.06 vs 0.51 ± 0.07, p=0.045) and older age (60±9 vs 57±8 years ; p=0.007).. At a 12-month follow-up, in the CTO group that was successfully revascularized by PCI, there was a better prognosis than the non-revascularized CTO group in terms of major cardiovascular events (19.9% vs 33.1% Plog-rank = 0.002). These results were consistent for all-cause mortality (5.5% vs 20.6%, Plog-rank =0.027), cardiac mortality (3.7% vs 20.6%, Plog-rank &amp;lt; 0.001) and rehospitalization events. (7.5% vs 32.2%, Plog-rank = 0.001). Conclusion: Successful revascularization of CTO by PCI may provide clinical benefits in patients with CTO in association with major cardiovascular events.</dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2022-07-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/1344</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2022.003.03.5</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 3 No. 3 (2022): Cardiovascular Disease in Young Adulthood: Who, When, and How to Screen?; 25-32</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2022.003.03</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/1344/251</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2022 Ratna Pancasari, Mohammad Saifur Rohman, Ardian Rizal, Novi Kurnianingsih, Anna Fuji Rahimah</dc:rights>
</oai_dc:dc>