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Correlation Study of Cotinine and Monocyte Chemoattractant Protein-1 (MCP-1) with Carotid Intima-Media Thickness (cIMT) in Male Active Tobacco Smoke

Heart Science Journal · Vol. 5 No. 1 (2024) · hlm. 24–27

DOI
10.21776/ub/hsj.2024.005.01.6
ISSN
2721-9984, 2721-9976
Terbit
2024-01-31
Penerbit
Universitas Brawijaya
Bahasa
en

Abstrak

Background: Tobacco smoke exposure induces intima-media thickness by reducing nitric oxide and increasing adhesive molecule activity, with circulating cotinine serving as a marker; we hypothesize a correlation between monocyte chemoattractant protein-1 (MCP-1) and carotid intima-media thickness (cIMT) in active male smokers. Method: We conducted an observational cross-sectional analytic study involving 125 male participants, with 62 being active tobacco smokers and 63 non-smokers. Data were presented as mean ± SD, and the correlation between variables was analyzed using Pearson correlation. Result: Cotinine and MCP-1 levels were significantly higher in the smoker population (p 0.000) compared to non-smokers. The incidence of positive cIMT findings was higher in the smoker group (5%) than in the non-smoker group (2%). In the active smoker population, cotinine (r 0.21; p 0.11) showed a positive but non-significant correlation with positive cIMT findings, while MCP-1 showed a negative correlation (r -0.19, p 0.14) with positive cIMT findings. Smoking duration (r 0.162; p 0.223) and the amount of tobacco smoke (r 0.003; p 0.982) demonstrated a positive correlation with cotinine. MCP-1 exhibited a non-significant positive correlation with smoking duration (r 0.122; p 0.345) and a non-significant negative correlation with the amount of tobacco smoke (r -0.002; p 0.989). Conclusion: Among active tobacco smokers, cotinine showed a positive but non-significant correlation with positive cIMT findings, while MCP-1 exhibited a non-significant negative correlation with positive cIMT findings.Â

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Rekan penulisOrganisasiArtikel bersama
Mohammad Saifur RohmanUniversity of Brawijaya58
Anna Fuji RahimahUniversity of Brawijaya39
Sasmojo WiditoUniversity of Brawijaya34
Setyasih AnjarwaniUniversity of Brawijaya26
Heny MartiniUniversity of Brawijaya25
Budi SatrijoUniversity of Brawijaya24
Indra PrasetyaUniversity of Brawijaya23
Yoga WaranugrahaUniversity of Brawijaya10
Adhika Prastya WikanandaUniversity of Brawijaya8
Wella KarolinaUniversity of Brawijaya8
Muhammad Rizki FadlanUniversity of Brawijaya6
Seprian WidasmaraUniversity of Brawijaya5
Valerinna YogibuanaAfiliasi tidak diketahui5
Putri Annisa KamilaUniversity of Brawijaya5
Anna Fuji RahimahAfiliasi tidak diketahui5
Valerinna Yogibuana Swastika PutriUniversity of Brawijaya5
Arif Ranu WicaksonoUniversity of Brawijaya5
Zainal FathurohimUniversity of Brawijaya5
Saskia Dyah HandariUniversity of Brawijaya4
Olivia HandayaniUniversity of Brawijaya4
Dadang HendrawanUniversity of Brawijaya4
Fahmy RusnantaUniversity of Brawijaya4
Ratna PancasariUniversity of Brawijaya4
Ayu Asri Devi AdityawatiUniversity of Brawijaya4
Tri AstiawatiUniversity of Brawijaya4
Nikhen NoverikeUniversity of Brawijaya4
Ira Vori NugrohoUniversity of Brawijaya4
Teguh AryanugrahaUniversity of Brawijaya4
Imam Mi'raj SuprayogaUniversity of Brawijaya4
Icmi Dian RochmawatiUniversity of Brawijaya3
Oktafin Srywati PamunaUniversity of Brawijaya3
Evit RuspionoAfiliasi tidak diketahui3
Dea Arie KurniawanUniversity of Brawijaya3
Puspa LestariUniversity of Brawijaya2

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Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Correlation Study of Cotinine and Monocyte Chemoattractant Protein-1 (MCP-1) with Carotid Intima-Media Thickness (cIMT) in Male Active Tobacco Smoke</dc:title>
	<dc:creator xml:lang="en">Satwikajati, Sawitri</dc:creator>
	<dc:creator xml:lang="en">Kurnianingsih, Novi</dc:creator>
	<dc:creator xml:lang="en">Tjahjono, Cholid Tri</dc:creator>
	<dc:creator xml:lang="en">Wihastuti, Titin Andri</dc:creator>
	<dc:creator xml:lang="en">Sargowo, Djanggan</dc:creator>
	<dc:creator xml:lang="en">Rizal, Ardian</dc:creator>
	<dc:subject xml:lang="en">Cotinine</dc:subject>
	<dc:subject xml:lang="en">MCP-1</dc:subject>
	<dc:subject xml:lang="en">Tobacco Smoke.</dc:subject>
	<dc:description xml:lang="en">Background : Tobacco smoke exposure induces intima-media thickness by reducing nitric oxide and increasing adhesive molecule activity, with circulating cotinine serving as a marker; we hypothesize a correlation between monocyte chemoattractant protein-1 (MCP-1) and carotid intima-media thickness (cIMT) in active male smokers. Method : We conducted an observational cross-sectional analytic study involving 125 male participants, with 62 being active tobacco smokers and 63 non-smokers. Data were presented as mean ± SD, and the correlation between variables was analyzed using Pearson correlation. Result : Cotinine and MCP-1 levels were significantly higher in the smoker population (p 0.000) compared to non-smokers. The incidence of positive cIMT findings was higher in the smoker group (5%) than in the non-smoker group (2%). In the active smoker population, cotinine (r 0.21; p 0.11) showed a positive but non-significant correlation with positive cIMT findings, while MCP-1 showed a negative correlation (r -0.19, p 0.14) with positive cIMT findings. Smoking duration (r 0.162; p 0.223) and the amount of tobacco smoke (r 0.003; p 0.982) demonstrated a positive correlation with cotinine. MCP-1 exhibited a non-significant positive correlation with smoking duration (r 0.122; p 0.345) and a non-significant negative correlation with the amount of tobacco smoke (r -0.002; p 0.989). Conclusion : Among active tobacco smokers, cotinine showed a positive but non-significant correlation with positive cIMT findings, while MCP-1 exhibited a non-significant negative correlation with positive cIMT findings. </dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2024-01-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/13096</dc:identifier>
	<dc:identifier>10.21776/ub/hsj.2024.005.01.6</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 5 No. 1 (2024): Inflammation and Cardiovascular Disease; 24-27</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2024.005.01</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/13096/393</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Sawitri Satwikajati, Novi Kurnianingsih, Djanggan Sargowo, Ardian Rizal</dc:rights>
</oai_dc:dc>