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Effects of the Low-Dose Colchicine Regimen on Left Ventricular Adverse Remodeling and Systolic Function in Acute Myocardial Infarction Patients With Anterior ST Segment Elevation Undergoing Primary Percutaneous Coronary Intervention: A Randomized Controlled Trial

Heart Science Journal · Vol. 5 No. 2 (2024) · hlm. 51–56

DOI
10.21776/ub/hsj.2024.005.02.9
ISSN
2721-9984, 2721-9976
Terbit
2024-04-28
Penerbit
Universitas Brawijaya
Bahasa
en

Abstrak

Background: Inflammation in reperfusion injury results in adverse ventricular remodeling and reduced systolic function. The anti-inflammatory effects of colchicine have shown beneficial effects in cardiovascular disease.Objective: To determine the effects of low-dose colchicine on left ventricular (LV) adverse remodeling and systolic function in acute myocardial infarction with anterior ST-segment elevation (anterior STEMI) patients undergoing primary percutaneous coronary intervention (PPCI).Material and Methods: This prospective, randomized, double-blinded study randomly assigned anterior STEMI patients who underwent PPCI to receive either low-dose colchicine (1mg loading dose followed by 0.5mg daily) or a matching placebo for 30 days in addition to standard therapy. Outcomes included adverse LV remodeling and systolic function, determined by transthoracic echocardiography (TTE) in the first and third month.Result: Enrollment comprised 196 patients, with 92 patients in the colchicine group and 104 patients in the placebo group. Adverse LV remodeling and a decrease in systolic function were observed in both groups. No significant differences in LV remodeling were observed between the colchicine and placebo groups, as indicated by the change in LV end-systolic volume index (LVESVI) at the first month (16.5% vs. 18.25% [p=0.091]) and third month (19.5% vs. 21.5% [p=0.124]). Similar results were found in LV systolic function between the colchicine and placebo groups, with a reduction in LV ejection fraction (LVEF) observed in the first month (6.3% vs. 8.95% [p=0.083]) and third month (9.5% vs. 11.5% [p=0.163]). Diarrhea was the only reported side effect, occurring in 6.5% of patients in the colchicine group.Conclusion: Low-dose colchicine administration in anterior STEMI patients undergoing PPCI did not reduce LV adverse remodeling or systolic function.

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  • University of Brawijaya
  • RSUD Prof. Dr. Saiful Anwar Malang
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
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Rekan penulisOrganisasiArtikel bersama
Anna Fuji RahimahUniversity of Brawijaya40
Cholid Tri TjahjonoUniversity of Brawijaya39
Ardian RizalUniversity of Brawijaya39
Novi KurnianingsihUniversity of Brawijaya29
Djanggan SargowoUniversity of Brawijaya24
Sasmojo WiditoUniversity of Brawijaya23
Heny MartiniUniversity of Brawijaya21
Yoga WaranugrahaUniversity of Brawijaya12
Muhammad Rizki FadlanUniversity of Brawijaya9
Valerinna YogibuanaAfiliasi tidak diketahui9
Wella KarolinaUniversity of Brawijaya8
Putri Annisa KamilaUniversity of Brawijaya8
Hayla Iqda MillisaniUniversity of Brawijaya7
Valerinna Yogibuana Swastika PutriUniversity of Brawijaya7
Tri AstiawatiUniversity of Brawijaya6
Tria Yudha NugrahaUniversity of Brawijaya6
Anna Fuji RahimahAfiliasi tidak diketahui6
Lutfi Hafiz ZunardiUniversity of Brawijaya6
Adhika Prastya WikanandaUniversity of Brawijaya5
Dea Arie KurniawanUniversity of Brawijaya5
Ayu Asri Devi AdityawatiUniversity of Brawijaya5
Seprian WidasmaraUniversity of Brawijaya5
Shalahuddin Suryo BaskoroUniversity of Brawijaya5
Yuri AfifahUniversity of Brawijaya5
Dadang HendrawanUniversity of Brawijaya4
Danti Utami SetyowatiRSUD Prof. Dr. Saiful Anwar Malang4
Krishna Ari NugrahaUniversity of Brawijaya4
Nikhen NoverikeUniversity of Brawijaya4
Teguh AryanugrahaUniversity of Brawijaya4
Saskia Dyah HandariUniversity of Brawijaya4
Fandy HazzyUniversity of Brawijaya3
Ratna PancasariUniversity of Brawijaya3
Mokhamad Aswin BaharUniversity of Brawijaya3
Ira Vori NugrohoUniversity of Brawijaya3
Muhammad Saifur RohmanAfiliasi tidak diketahui3

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Effects of the Low-Dose Colchicine Regimen on Left Ventricular Adverse Remodeling and Systolic Function in Acute Myocardial Infarction Patients With Anterior ST Segment Elevation Undergoing Primary Percutaneous Coronary Intervention: A Randomized Controlled Trial</dc:title>
	<dc:creator xml:lang="en">Caesario, Fahreza</dc:creator>
	<dc:creator xml:lang="en">Prasetya, Indra</dc:creator>
	<dc:creator xml:lang="en">Rohman, Mohammad Saifur</dc:creator>
	<dc:creator xml:lang="en">satrijo, Budi</dc:creator>
	<dc:creator xml:lang="en">Anjarwani, Setyasih</dc:creator>
	<dc:subject xml:lang="en">Colchicine</dc:subject>
	<dc:subject xml:lang="en">STEMI</dc:subject>
	<dc:subject xml:lang="en">Reperfusion Injury</dc:subject>
	<dc:subject xml:lang="en">Adverse Remodelling</dc:subject>
	<dc:subject xml:lang="en">Systolic Function</dc:subject>
	<dc:description xml:lang="en">Background: Inflammation in reperfusion injury results in adverse ventricular remodeling and reduced systolic function. The anti-inflammatory effects of colchicine have shown beneficial effects in cardiovascular disease.Objective: To determine the effects of low-dose colchicine on left ventricular (LV) adverse remodeling and systolic function in acute myocardial infarction with anterior ST-segment elevation (anterior STEMI) patients undergoing primary percutaneous coronary intervention (PPCI).Material and Methods: This prospective, randomized, double-blinded study randomly assigned anterior STEMI patients who underwent PPCI to receive either low-dose colchicine (1mg loading dose followed by 0.5mg daily) or a matching placebo for 30 days in addition to standard therapy. Outcomes included adverse LV remodeling and systolic function, determined by transthoracic echocardiography (TTE) in the first and third month.Result: Enrollment comprised 196 patients, with 92 patients in the colchicine group and 104 patients in the placebo group. Adverse LV remodeling and a decrease in systolic function were observed in both groups. No significant differences in LV remodeling were observed between the colchicine and placebo groups, as indicated by the change in LV end-systolic volume index (LVESVI) at the first month (16.5% vs. 18.25% [p=0.091]) and third month (19.5% vs. 21.5% [p=0.124]). Similar results were found in LV systolic function between the colchicine and placebo groups, with a reduction in LV ejection fraction (LVEF) observed in the first month (6.3% vs. 8.95% [p=0.083]) and third month (9.5% vs. 11.5% [p=0.163]). Diarrhea was the only reported side effect, occurring in 6.5% of patients in the colchicine group.Conclusion: Low-dose colchicine administration in anterior STEMI patients undergoing PPCI did not reduce LV adverse remodeling or systolic function.</dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2024-04-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/15773</dc:identifier>
	<dc:identifier>10.21776/ub/hsj.2024.005.02.9</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 5 No. 2 (2024): Challenges in the Management of Congenital Heart and Structural Heart Diseases; 51-56</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2024.005.02</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/15773/405</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Fahreza Caesario</dc:rights>
</oai_dc:dc>