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Hype or hope: The role of alcohol septal ablation in improving outcomes for young patients with obstructive hypertrophic cardiomyopathy: A case series

Heart Science Journal · Vol. 6 No. 3 (2025)

DOI
10.21776/ub.hsj.2025.006.03.19
ISSN
2721-9984, 2721-9976
Terbit
2025-07-31
Penerbit
Universitas Brawijaya
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: Hypertrophic cardiomyopathy (HCM) is a disease that has a poor prognosis and a higher likelihood of death in young people. Alcohol septal ablation (ASA) is a minimally invasive procedure that involves the injection of ethanol through a septal perforator to lead to infarction of the hypertrophied septum. This case series aims to present data on the beneficial effects of ASA in promoting hope for enhanced outcomes in young patients with HCM. Case: Patient 1: A 32-year-old male with HCM has been suffering from chest discomfort and atrial fibrillation since 2020. Echocardiography detected an increased obstruction in the left ventricular outflow tract (LVOT), resulting in a gradient of 104 mmHg. The patient underwent ASA to decrease the gradient to 37 mmHg, reducing hospitalizations throughout a 12-month follow-up period. Patient 2: A 27-year-old female diagnosed with HCM has been frequently suffering episodes of near syncope and shortness of breath with light activity over the past 6 months. The echocardiography findings showed a significant increase in the resting gradient in the LVOT. Following ASA, the resting gradient decreased to 54 mmHg during a 3-month follow-up. The patient did not suffer further near syncope events, and her NYHA functional class improved throughout a 9-month follow-up period. Conclusion: The effectiveness of ASA as a treatment option is hope for young patients with obstructive HCM, which is demonstrated in this case series, leading to relieving symptoms, reduced repeated hospitalization, and improved functional capacity.

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  • University of Brawijaya
  • RSUD Prof. Dr. Saiful Anwar Malang
  • Afiliasi tidak diketahui
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Rekan penulisOrganisasiArtikel bersama
Mohammad Saifur RohmanUniversity of Brawijaya58
Setyasih AnjarwaniUniversity of Brawijaya37
Heny MartiniUniversity of Brawijaya30
Cholid Tri TjahjonoUniversity of Brawijaya24
Novi KurnianingsihUniversity of Brawijaya24
Djanggan SargowoUniversity of Brawijaya17
Budi SatrijoUniversity of Brawijaya17
Sasmojo WiditoUniversity of Brawijaya16
Nikhen NoverikeUniversity of Brawijaya9
Yoga WaranugrahaUniversity of Brawijaya7
Adhika Prastya WikanandaUniversity of Brawijaya6
Valerinna Yogibuana Swastika PutriUniversity of Brawijaya6
N KaputrinUniversity of Brawijaya6
Tria Yudha NugrahaUniversity of Brawijaya5
Icmi Dian RochmawatiUniversity of Brawijaya5
Danti Utami SetyowatiRSUD Prof. Dr. Saiful Anwar Malang5
Tri AstiawatiUniversity of Brawijaya5
Muhammad Rizki FadlanUniversity of Brawijaya4
Hayla Iqda MillisaniUniversity of Brawijaya4
Lukitasari Ayu Galuh ArdhiUniversity of Brawijaya4
Putri Annisa KamilaUniversity of Brawijaya4
Fahmy RusnantaUniversity of Brawijaya4
Ratna PancasariUniversity of Brawijaya4
Seprian WidasmaraUniversity of Brawijaya4
Dea Arie KurniawanUniversity of Brawijaya4
Olivia HandayaniUniversity of Brawijaya3
Anita Surya SantosoAfiliasi tidak diketahui3
Fitranti Suciati LaitupaUniversity of Brawijaya3
Ayu Asri Devi AdityawatiUniversity of Brawijaya3
Teguh AryanugrahaUniversity of Brawijaya3
Puspa LestariUniversity of Brawijaya2
Veny KurniawatiUniversity of Brawijaya2
Ardian RizalUniversity of Brawijaya2
Anna Fuji RahimahAfiliasi tidak diketahui2

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://heartscience.ub.ac.id/index.php/heartscience/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Hype or hope: The role of alcohol septal ablation in improving outcomes for young patients with obstructive hypertrophic cardiomyopathy: A case series</dc:title>
	<dc:creator xml:lang="en">Saputri, Vemmy Lian</dc:creator>
	<dc:creator xml:lang="en">Rizal, Ardian</dc:creator>
	<dc:creator xml:lang="en">Rahimah, Anna Fuji</dc:creator>
	<dc:creator xml:lang="en">Karolina, Wella</dc:creator>
	<dc:creator xml:lang="en">Yogibuana, Valerinna</dc:creator>
	<dc:creator xml:lang="en">Prasetya, Indra</dc:creator>
	<dc:subject xml:lang="en">Alcohol septal ablation</dc:subject>
	<dc:subject xml:lang="en">obstructive hypertrophic cardiomyopathy</dc:subject>
	<dc:subject xml:lang="en">technical approach</dc:subject>
	<dc:subject xml:lang="en">clinical outcome</dc:subject>
	<dc:description xml:lang="en">Background: Hypertrophic cardiomyopathy (HCM) is a disease that has a poor prognosis and a higher likelihood of death in young people. Alcohol septal ablation (ASA) is a minimally invasive procedure that involves the injection of ethanol through a septal perforator to lead to infarction of the hypertrophied septum. This case series aims to present data on the beneficial effects of ASA in promoting hope for enhanced outcomes in young patients with HCM.
Case: Patient 1: A 32-year-old male with HCM has been suffering from chest discomfort and atrial fibrillation since 2020. Echocardiography detected an increased obstruction in the left ventricular outflow tract (LVOT), resulting in a gradient of 104 mmHg. The patient underwent ASA to decrease the gradient to 37 mmHg, reducing hospitalizations throughout a 12-month follow-up period.
Patient 2: A 27-year-old female diagnosed with HCM has been frequently suffering episodes of near syncope and shortness of breath with light activity over the past 6 months. The echocardiography findings showed a significant increase in the resting gradient in the LVOT. Following ASA, the resting gradient decreased to 54 mmHg during a 3-month follow-up. The patient did not suffer further near syncope events, and her NYHA functional class improved throughout a 9-month follow-up period.
Conclusion: The effectiveness of ASA as a treatment option is hope for young patients with obstructive HCM, which is demonstrated in this case series, leading to relieving symptoms, reduced repeated hospitalization, and improved functional capacity.</dc:description>
	<dc:publisher xml:lang="en">Universitas Brawijaya</dc:publisher>
	<dc:date>2025-07-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20191</dc:identifier>
	<dc:identifier>10.21776/ub.hsj.2025.006.03.19</dc:identifier>
	<dc:source xml:lang="en">Heart Science Journal; Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visualization</dc:source>
	<dc:source>2721-9984</dc:source>
	<dc:source>2721-9976</dc:source>
	<dc:source>10.21776/ub.hsj.2025.006.03</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://heartscience.ub.ac.id/index.php/heartscience/article/view/20191/517</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Vemmy Lian Saputri, Ardian Rizal, Anna Fuji Rahimah, Wella Karolina, Valerinna Yogibuana, Indra Prasetya</dc:rights>
	<dc:rights xml:lang="en">http://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>